Steroid cell tumour of ovary: A rare clinicopathologic entity (original) (raw)
Related papers
Steroid cell tumour of the ovary: a case report with review of literature
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Virilising ovarian tumours account for less than 5% of all ovarian tumours. A steroid cell tumour (SCTs) of the ovary comes under the sex cord stromal tumours and accounts for only 0.1% of all ovarian tumours. Almost 75% are functioning tumors with production of androgenic hormones causing virilisation and cushingoid features. They are usually unilateral, benign with only 25-45% malignant cases. Here authors report the incidence of steroid cell tumour in our institution and discuss about a 37-year-old woman with steroid cell tumour, not otherwise specified who presented with oligomenorrhea followed by amenorrhea, secondary infertility and signs of virilisation.
Rare Case of Ovarian Steroid Cell Tumor Not Otherwise Specified in a Postmenopausal Woman
Journal of Morphological Sciences, 2022
Ovarian steroid cell tumors, not otherwise specified (NOS), are rare ovarian sex cord-stromal tumors with malignant potential. They represent less than 0.1% of all ovarian neoplasms. Little is known about this tumor, it is rare, and only a small number of case reports are available in the literature. This type of tumor can produce testosterone, leading to hyperandrogenism, virilization and amenorrhea. Postmenopausal occurrences are rare. We present a 60-year-old woman with onset of virilization, worsening alopecia and excessive growth of hair on abdominal and genital parts of the body. She has elevated levels of adrenal androgens. Radiologic studies were consistent with left sided ovarian changes. A diagnostic and therapeutic bilateral salpingo-oophorectomy confirmed steroid cell tumor NOS in both ovaries. Post-operatively, the patient had complete resolution of her symptoms and normalization of testosterone levels.
Steroid Cell Tumor of the Ovary: A Rare Case Report
Apollo Medicine, 2008
Sex cord-stromal tumors (SCST) are rare tumors of the ovary that include three main subtypes known as pure stromal tumors, pure sex cord tumors, and mixed sex-cord stromal tumors. This case involves a 25year-old female who presented to the Gynecology outpatient clinic with a two-year history of amenorrhea associated with excessive hair growth since menarche. Ultrasonography revealed a solid left ovarian mass. Histopathology confirmed a diagnosis of SCST not otherwise specified with no cytological atypia. In this case report, we describe the process of managing this patient and a brief literature review on the updates regarding the clinical presentation, molecular changes, and management of SCSTs not otherwise specified.
Journal of ovarian research, 2013
Ovarian steroid cell tumors, not otherwise specified (NOS) are rare sex cord-stromal tumors of the ovary with malignant potential. So far only a few cases were reported in English literature through the Pubmed search. Here we report two cases of such tumor, one was benign (first case underwent laparoscopic cystectomy) and the other was malignant (died 10 months later after initial diagnosis), both presented with amenorrhea and clinical signs or symptoms of virilization. In malignant case, we provided evidence (tumor embolus) in addition to the reported five characteristics associated with malignancy. On further evaluation, laboratory investigations revealed hyperandrogenism in the male range, while follicle stimulating hormone (FSH) and luteinising hormone (LH) levels were within normal limits. Various aspects of the presentation, diagnosis, and treatment of these tumors are discussed.
A rare cause of virilization; Ovarian steroid cell tumor, not otherwise specified (NOS)
Journal of the Turkish German Gynecological Association, 2012
Sex cord-stromal tumors account for 5% of ovarian tumors and 2% of malignant ovarian tumors. Steroid cell tumors (SCT), not otherwise specified (NOS), are rare sex cord-stromal tumors of the ovary and account for less than 0.1% of all ovarian tumors. We report a rare case of a postmenopausal woman presented with hirsutism, virilism and with findings of hyperestrogenism.
Ovarian Steroid Cell Tumor: Report Of Four Cases
Journal of Turkish Society of Obstetric and Gynecology, 2013
Steroid cell tumors are tumors that account for less than 0.1% of all ovarian malignant tumors and cause increase in secretion of androgen or estrogen. Steroid cell tumors usually occur in the post-menopausal period. This article reports four steroid cell tumor cases who underwent surgery for overian mass during post-menopausal period, who were diagnosed with steroid cell tumor after histopathological examination and displayed different clinical manifestations. No signs of increased hormonal activity in two of these cases were observed. On the other hand, the other two cases applied with complaints of menopausal vaginal bleeding, which led to the consideration of increased estrogenic activity in these two cases.
Ovarian Steroid Cell Tumor: A Case Report
IOSR Journals , 2019
Introduction: Ovarian steroid cell tumors are a rare subgroup of sex cord stromal tumors of the ovary and comprise less than 0.1% of all ovarian tumors. Case report: A 12 year old patient presented with abdominal pain and found to have right ovarian cyst, right ovarian cystectomy done for the same and histopathology revealed ovarian steroid cell tumor and the same was confirmed by immunohistochemistry with positivity for Vimentin, Calretinin and Inhibin. Conclusion: Ovarian steroid cell tumours, NOS, are rare tumours. Along with clinical correlation, histopathology is the gold standard to confirm the diagnosis in most of the cases. In atypical cases, immunohistochemistry can be helpful for accurate diagnosis. The treatment varies from ovarian cystectomy to total abdominal hysterectomy with bilateral salpingo-oophorectomy depending on histopathological features of malignancy.
An Early Diagnosis of an Ovarian Steroid Cell Tumor Not Otherwise Specified in a Woman
Case Reports in Obstetrics and Gynecology, 2019
Steroid cell tumor not otherwise specified is a subtype of steroid ovary tumors. These are a rare subgroup of ovarian sex cord-stromal tumors. We present a case of a young woman submitted to laparoscopic cystectomy with ovarian steroid cell tumor as histological finding. This represents the second case where laparoscopic cystectomy is performed in this type of tumor. Up to 36 months after surgery, the woman remains under surveillance, without recurrence of the tumor, and attempts to conceive. This case suggests that steroid cell tumors can be asymptomatic, and gynecologists must think about preserving fertility in women of reproductive age.
Macedonian Journal of Medical Sciences, 2013
Introduction: Steroid cell tumors of the ovary present less than 0.1% of all ovarian tumors and belong in the group of sex cord-stromal tumors. Case description: We present a case of 69-year-old woman investigated because of postmenopausal bleeding, a 5-year history of excessive hirsutism, baldness and acne. The evaluation revealed elevated serum testosterone, but ultrasound detected a 2 cm-mass of the left ovary. The patient underwent hysterectomy and bilateral adnexectomy. The histopathology diagnosis was steroid cell tumor, not otherwise specified. Postoperative chemotherapy was administered at the discretion of the radio-oncologist. At the last follow-up 48 months after surgery, the hirsutism was completely resolved, the serum testosterone was within the normal range and there was no evidence of recurrence. Conclusion: In adult patients with hirsutism and elevated serum testosterone a possibility of a presence of an ovarian steroid cell tumor should be considered. Surgery is the main treatment of such patients.
An ovarian steroid cell tumor with virilization and hypothyroidism: a case report
Gynecological Surgery, 2008
Steroid cell tumors are rare ovarian sex-cord stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. The diagnosis of these rare tumors can be problematic especially in the case of a small nonpalpable ovarian tumor. A 41-year-old woman presented with the gradual onset of defeminization, mild hypothyroidism, and virilization. A physical examination revealed a relatively healthy woman with borderline hirsutism, clitoromegaly and adnexal fullness without a palpable tumor. Elevated serum levels of TSH and testosterone were found preoperatively. Five weeks after an oophorectomy, serum levels of TSH and testosterone returned to normal and menstruation returned. Nonpalpable virilizing ovarian steroid cell tumors may be difficult to diagnose. A careful study of the patient's history, the development of defeminization followed by virilization, and a "characteristic" ultrasonogram, can be helpful for diagnosis. Hormonal studies including thyroid function should also be considered in an ovarian steroid cell tumor.