Effects of Alchemilla mollis and Alchemilla persica on the wound healing process (original) (raw)

2016, Bangladesh Journal of Pharmacology

Alchemilla genus plants are herbaceous perennial plants from the family Rosaceae, known as their common name "Lady's mantle". The most popular species of this genus is A. vulgaris L. The medicinal part of the plant is the aerial part, collected in flowering season, which is also recorded in ESCOP Monographs and approved by Commision E in order to be used against diarrhea as well as gastrointestinal complaints hemorrhoids and dysmenorrhoae and externally in the cases of stomatitis and wound healing (ESCOP Monographs, 2003; Gruenwald et al., 2000; Neagu et al., 2015). Indeed, in traditional medicine, Alchemilla species have been used internally for the treatment of menopausal complaints, dysmenorrhea, gastrointestinal disorders, mouth and throat inflammation and externally for ulcers, eczema and skin rashes (Kupeli Akkol et al., 2015). One of these species, A. mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation (Makau et al., 2013; Trendafilova et al., 2011; Yarnel and Abascal, 2009). Previous studies on A. mollis have revealed that the plant has antiviral, astringent, diuretic, antispasmodic and anti-oxidant activities (Makau et al., 2013; Trendafilova et al., 2011) due to its phenolic content; tannins, flavonoid glycosides (Trendafilova et al., 2011). This study was designed to screen the wound healing activity potential of two Alchemilla species namely, A. mollis and A. persica, growing wild in Turkey, by conducting in vivo bioassays. Materials and Methods Plant material Both the aerial parts and roots of A. mollis and A. persica