Gabapentina preoperatoria como adyuvante en el manejo del dolor agudo postoperatorio en histerectomía abdominal (original) (raw)
2015, Revista Sociedas Española de Dolor
Background: It is well known that pain is subjective symptom and postoperative pain continues prevalence worldwide, because despite all the progress has not yet been able to eradicate completely. Objective: To evaluate the adjuvant effect on postoperative pain intensity 600 mg of gabapentin administered preoperatively in patients undergoing abdominal hysterectomy at St. Thomas Hospital from April to August 2014. Methods: An experimental study cohort prospective randomized, controlled, double blind study in patients undergoing abdominal hysterectomy was performed under general anesthesia. Were randomized into two groups: gabapentin group-gabapentin 600 mg (2 hours preoperative) + analgesia morphine through pump patient controlled analgesia (PCA)-and control group-analgesia with morphine via PCA pump; morphine dose was calculated based on weight ranges to 0.016 mg/kg/h. Pain intensity scale with verbal numeric scale (VNS) of 11 points at 2, 6 and 24 hours were evaluated, the number of rescues administered postoperatively was quantified and the prevalence of adverse events in both groups was measured. Results: Seventy-two patients splitted into two homogeneous groups were recruited, the average age was 44.72 ± 6.17 years in gabapentin group and 49.36 ± 9.31 years in control group. As for postoperative pain was statistically significant difference between the two groups (p < 0.05), a difference was found in the VNS of 11 points, 4.27 ± 2.32, 1.94 ± 1.95 and 0.77 ± 1.28 in gabapentin group and 7.13 ± 2.41, 4.5 ± 2.37 y 3.25 ± 2.18 in control group at 2, 6 and 24 hours respectively; the amount of ransom administered by PCA pump during the first 24 postoperative hours was measured was 6.72 ± 5.7 for gabapentin group and 24.13 ± 47.01 for control group, a statistically significant difference (p < 0.05); the prevalence of adverse effects was not statistically significant between groups. Conclusion: These results indicate that gabapentin at doses of 600 mg preoperative is a valid therapeutic option in preoperative analgesia for abdominal hysterectomy. Note that we have yet to elucidate the optimal effective dose and to present lower incidence of adverse effects.
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.