Plant Isolated Compound Remove Uric Acid from Blood Immediately as Compare to Anti Uric Acid Drug (original) (raw)
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Gokshuradi Yog (GY) is a polyherbal ayurvedic formulation used traditionally for several decades in India for the treatment of urolithiasis. The aim of the present study was to determine the underlying mechanism of GY action in the management of calcium oxalate urolithiasis. The effect of Gokshuradi polyherbal aqueous extracts (GPAEs) was studied on various biochemical parameters involved in calcium oxalate formation by employing in vitro and in vivo methods. GPAE exhibited significant antioxidant activity against 1, 1-diphenyl-2-picrylhydrazyl free radical and inhibited lipid peroxidation in the in vitro experiments. The rat model of urolithiasis induced by 0.75% ethylene glycol (EG) and 1% ammonium chloride (AC) in water caused polyuria, weight loss, impairment of renal function, and oxidative stress and decreased antioxidant enzyme activities in untreated control groups. However, GPAE-(25, 50, and 100 mg/kg) treated groups caused diuresis accompanied by a saluretic effect and revealed significant increase in antioxidant enzyme activities along with decreased oxalate synthesizing biochemical parameters at higher doses. This study revealed the antiurolithic effect of GPAE mediated possibly through inhibiting biochemical parameters involved in calcium oxalate formation, along with its diuretic and antioxidant effects, hence supporting its use in the treatment of calcium oxalate urolithiasis.
The composition of the goutweed fower essential oil from Kharkiv region (Ukraine) was studied using gas chromatography-mass spectrometry. Sesquiterpenes have been found to be the main group of the essential oil. The principal compounds contained in the oil were β-farnesene (43.94%), α-bergamoten (15.32%), (E, E)-α-farnesene (8.84%) and 1,5,9,9-tetramethyl-1,4,7-cycloundecatrien (5.51%). Diuretic and uricosuric activity of the goutweed fower essential oil in a dose of 1 mg/kg has been determined for the frst time. It has been shown that the single dose increases creatinine, urea and uric excretion with the urine volume being unchanged. In the course of administration, a diuretic effect appears, creatinine excretion returns to the initial state while urea and uric acid excretion decreases. No signifcant differences between the effects of the aforesaid essential oil and the reference drug olimetin are observed. Thus, the essential oil may be involved in the diuretic and uricosuric acti...
ANALYSIS ON ANTIOXIDANT ACTIVITY OF SELECTED ANTI- GOUT MEDICINAL PLANTS a
Journal of Applied Science and Computations Volume VI, Issue V, May/2019 ISSN NO: 1076-513, 2019
Gout, a common rheumatic disease worldwide, is an inflammatory syndrome with pathogenic basis of hyperuricemia, which usually exceeds 390 μmol/L or 6.5 mg/dL of uric acid level in the serum and thereby leads to crystal formation of monosodium urate (MSU) in various tissues, especially in the joints. Compared with women, men have a four-to nine fold increased risk of developing gout. Although numerous synthetic drugs were developed for the treatment of Gou but the safe and effective treatment paradigm is yet to be achieved. Plants such as Andrographis paniculata, Cissus quadrangulari, Michelia champaca, Tinospora cordifolia, Zingiber officinale, Carica papaya and Tephrosia purpurea were subjected to antioxidant activity analysis such as Catalase, Superoxide dismutase (SOD) and glutathione. All the test plants were positively having more antioxidant activity and mostly the activity is comparable to the positive control and extracts concentration dependent. Evidences showed that phytoconstituents such as alkaloids, flavonoids, polyphenolics, phytosterol, saponins, fixed oils and fats, carbohydrates, amino acids and proteins and many other types of highly useful phytoconstituents were found out from all the test plants and many of them were found to have many biological activities including antioxidant activity. The effectiveness of the plant derived drug is dose dependent and as they are free of side effects they could be used even a slight higher concentration compared to allopathic drugs and chemicals..
Anxiolytic effect of acute administration of ursolic acid in rats
Research Journal of …, 2011
Anxiety is a cardinal symptom of many psychiatric disorders and an almost inevitable component of many medical and surgical conditions. Indeed it is a universal human emotion, closely allied with appropriate fear presumably serving pyschobiologically adaptive purposes. Anxiety is a normal emotional behavior. When it is severe and/or chronic, however, it becomes pathological and can precipitate or aggravate cardiovascular and psychiatric disorders. Although many drugs are available in allopathic medicine to treat anxiety disorders, they produce various systemic side effects. Ursolic acid has been identified as the active principle of Ocimum sanctum. From our laboratory we have established the antianxiety, anticateleptic and antidepressant activity of ethanolic extract of leaves of Ocimum sanctum. In the present study, we have attempted to evaluate the anxiolytic-activity of ursolic acid in rats by employing, elevated plus maze and bright and dark arena. The rats were divided into five groups, each group containing six animals. The effects of the test drug ursolic acid (at 0.05, 0.1 and 0.2 mg/kg doses), the standard anxiolytic, diazepam (1.0 mg/kg) and control group 14% dimethyl sulfoxide (10ml/kg) were assessed after single dose administration. The results suggest that, ursolic acid exhibited anxiolytic like activity comparable to diazepam
Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020), 2021
Hyperuricemia is an elevated level of uric acid in the blood that induces uric acid needle shaped crystals saturation resulting in joint stiffness. Anting-anting leaf contains quercetin and kaempferol which are capable of decreasing uric acid in the body. The purpose of this study was to determine the effect of ethanol extract of anting-anting leaves (Acalypha indica L.) in decreasing uric acid levels in male rats Sprague Dawley induced by caffeine. This is an experimental research using 25 male rats, which were divided into 5 groups: negative, positive group, and three groups given the extract dose of 3.15 g/BW, 6.3 g/BW and 12.6 g/BW. Data were obtained from the examination of normal levels of uric acid, the level of uric after induction and the level after the treatment. Data were analyzed using one-way ANOVA. The test results showed that ethanol extracts of anting-anting leaf dose of 12.6 g/BW could significantly decrease uric acid levels in male rats' blood that was induced by caffeine dose of 5.29 mg/200gBW and was equivalent to the level of positive control (allopurinol 1.8 mg/200gBW). It is concluded that ethanol 96% extract of anting-anting leaf (Acalypha indica L.) has an effective effect in decreasing uric acid.
Asian Journal of Pharmaceutical and Clinical Research
Objective: Hyperuricemia (high uric acid levels) prevalence increased year by year. This study was aimed to elaborate the in vitro xanthine oxidase (XO) inhibitory activity and in vivo lowering hyperuricemic effect of Uncaria gambir (Hunter) Roxb) (gambir), Caesalpinia sappan L. (secang) and the combined extract of secang and gambir (formulae extract [FE]).Methods: Gambir and secang extracts were prepared by maceration with ethanol and FE was the proportioned combination of these two extracts. XO inhibitory activity was determined by measuring the formation of uric acid in the xanthine/XO system in vitro using allopurinol as a positive control at 100 ug/mL. Antioxidant activity was by 1,1-diphenyl-2-picrylhydrazyl radical reducing methods. The in vivo experiments were conducted in the oxonate-induced hyperuricemia rat model, in which FE was gavaged p.o. at the arrange dose of 75, 150, and 300 mg/kg bw for 2 weeks. Polyphenol content was measured using Folin–Ciocalteu reagent spectr...
Asian Journal of Pharmacy and Pharmacology, 2020
Hyperuricemia ensues due to the reabsorption and diminished evacuation of uric acid which is accountable for the advancement of gout and radically concomitant with the progress of numerous long-lasting ailments for instance malignant tumor, cardiovascular ailments, and kidney failure. Underlying factors such as excessive intake of purine containing supplements, obesity, age, sex, sugar, and alcohol intake may condense the formation of uric acid and exaggerate the injurious effects of uric acid. Novel inventive pharmaceutical and curative mediations are being used for the tackling of hyperuricemia but the problem arises when patients complain about adverse reactions with serious complications that may increase the rate of developing new diseases. Medicinal and dietary plants with bioactive phytochemicals like polyphenols, flavonoids are more feasible due to less toxicity, more economical for developing countries, formulation advantages for primary healthcare, better appropriateness with human physiological conditions. To facilitate the design of plant-based alternative therapy it is a prerequisite to connecting herbal medicine with novel prescription and additional precise explorations have to be ensured for the authentication of the effectiveness and safety of herbal formulations. The existing assessment outlines production, metabolism, and excretion of uric acid, hazard influences (overabundance and low excretion of uric acid), conventional pharmacotherapy for hyperuricemia and its related complications, the use of plants, its origin; parts to be used, mechanism of actions to preclude hyperuricemia are highlighted based on of previously issued literature.
Cureus, 2021
Background The principal manifestation of hyperuricemia is gout. Many drugs are in use nowadays to treat gout, but they are linked with multiple side effects. The present study observed berberine (from Chinese folk medicine) on serum and urinary uric acid levels in rats with potassium oxonate-induced hyperuricemia. Materials and methods Thirty-six adult healthy female Sprague Dawley rats were randomly divided into six groups of six rats each. To induce hyperuricemia, all the groups except Group A were given potassium oxonate (250 mg/kg) intraperitoneally on days 1, 3, and 7. Group A, the normal control group, was given normal saline for seven consecutive days intraperitoneally. Group C was administered allopurinol (5 mg/kg body weight) intraperitoneally, and Group D, E, and F were given berberine in doses of 0.75 mg/kg, 1.25 mg/kg, and 2.5 mg/kg body weight respectively intraperitoneally for seven consecutive days, one hour after the potassium oxonate injection. On zero, first, thir...
PHYTOCONSTITUENTS AND ANTI-GOUT ACTIVITY ANALYSIS OF SELECTED MEDICINAL PLANTS a
Pramana Research Journal, 2019
Gout, a common rheumatic disease worldwide, is an inflammatory syndrome with pathogenic basis of hyperuricemia, which usually exceeds 390 μmol/L or 6.5 mg/dL of uric acid level in the serum and thereby leads to crystal formation of monosodium urate (MSU) in various tissues, especially in the joints. Compared with women, men have a four-to nine fold increased risk of developing gout Plants such as Andrographis paniculata, Cissus quadrangulari, Michelia champaca, Tinospora cordifolia, Zingiber officinale, Carica papaya and Tephrosia purpurea were subjected to phytoconstituents and anti-diabetic activity analysis. Tinospora cordifolia and Costus pictus was found to have positive result for alkaloids, flavonoids, polyphenolics, phytosterol, fixed oils and fats, carbohydrates amino acids and proteins. Andrographis paniculata, Cissus quadrangulari and Zingiber officinale have been found to have alkaloids, flavonoids, polyphenolics, phytosterol, fixed oils and fats, carbohydrates amino acids and proteins. The phytochemicals content varied from solvent to solvent used for extraction. Many types of highly useful phytoconstituents were found out from all the test plants and many of them were found to have many biological activities including antigout activity. This was proved in their anti-gout activity. Effect of plant extracts on serum uric acid level in normal and gout induced rats were tested along with xanthine oxidase inhibition activity. All the plants were identified to have anti-gout activity. This study has clearly showed that the plants after purifying the phytoconstituents could effectively be used as anti diabetic plant derived drug, which are free from side effects.
Comparatve uric acid lowering studies of allopurinol with an indigenous medicinal plant in rabbits
Acta poloniae pharmaceutica
The aim of this research was to carry out a comparative study of lowering of uric acid by the use of dried powder of Colchicum luteum and allopathic drug (allopurinol) in rabbits, to determine whether herbal drugs can be used by patients instead of allopathic drugs. The herbal medicine, dried corm powder of Colchicum luteum 2.5 mg/kg/day and dried powder of allopurinol 2 mg/kg/day an allopathic medicine, was used in the study. The results of these medicines were observed in animal model, using 12 adult rabbits, which were divided into three groups A, B and C, respectively, where group C was taken as control. The SPSS version 17 was used for statistical analysis and analysis of variance (ANOVA) was used for comparing the data in different groups and the level of significance was 5%. It was resulted that dried corm of Colchicum luteum significantly reduced the uric acid in adult rabbits as reduced by allopathic medicine--allopurinol. In the light of present research we concluded that ...