Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses (original) (raw)
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Scientific Reports, 2019
Two cobalt(III) Schiff base complexes, trans-[Co(salen)(DA) 2 ](Clo 4) (1) and trans-[Co(salophen)(DA) 2 ] (Clo 4) (2) (where salen: N,N'-bis(salicylidene)ethylenediamine, salopen: N,N'-bis(salicylidene)-1,2phenylenediamine, DA: dodecylamine) were synthesised and characterised using various spectroscopic and analytical techniques. The binding affinity of both the complexes with CT-DNA was explored adopting UV-visible, fluorescence, circular dichroism spectroscopy and cyclic voltammetry techniques. The results revealed that both the complexes interacted with DNA via intercalation as well as notable groove binding. protein (BsA) binding ability of these complexes was investigated by absorption and emission spectroscopy which indicate that these complexes engage in strong hydrophobic interaction with BSA. The mode of interaction between these complexes and CT-DNA/BSA was studied by molecular docking analysis. the in vitro cytotoxic property of the complexes was evaluated in A549 (human small cell lung carcinoma) and VeRo (African green monkey kidney cells). the results revealed that the complexes affect viability of the cells. AO and EB staining and cell cycle analysis revealed that the mode of cell death is apoptosis. Both the complexes showed profound inhibition of angiogenesis as revealed in in-vivo chicken chorioallantoic membrane (CAM) assay. of the two complexes, the complex 2 proved to be much more efficient in affecting the viability of lung cancer cells than complex 1. These results indicate that the cobalt(III) Schiff base complexes in this study can be potentially used for cancer chemotherapy and as inhibitor of angiogenesis, in general, and lung cancer in particular, for which there is need for substantiation at the level of signalling mechanisms and gene expressions. Metal-based therapeutics have become a viable area of research in medicinal chemistry after the serendipitous discovery of cis-platin. At present nearly half the number of cancer patients are treated with platinum-based drugs 1,2. However, platinum-based drugs are associated with (i) adverse side effects, (ii) lack of selectivity and (iii) intrinsic or acquired resistance, which prompted search for effective non-platinum drugs. Over the years, complexes of Ru, Ir, Cu, Ni, Zn, Co, etc., have been reported to posses much better anticancer property than cis-platin 3-6. Cobalt is an essential trace element present in the human body. It is involved in important biological functions such as fatty acid and amino acid metabolism, haematopoiesis, and, in the form of vitamin B 12 it is
The development of new medicines for the successful treatment of cervical and liver malignancies is critical in order to address the disadvantages of current chemotherapeutics, such as increased resistance. Metal ion-based chemical complexes have recently emerged as a prominent method for cancer therapy. As a result, the study aims to create novel anticancer medicines based on leads acquired through combinatorial chemistry of metal complexes. Cobalt (III) Schiff base trans- [Co(salen)(DA)2](ClO4) (complex 1) and trans-[Co (salophen)(DA)2](ClO4) (complex 2)] where, the salen and salopen were N, N′-bis(salicylidene) ethylenediamine, and N, N′-bis(salicylidene)-1,2- phenylenediamine, DA: dodecylamine) were synthesized as an alternative to the existing drugs, and their cytotoxic effect were evaluated against human cervical (HeLa) and liver cancer cell lines (HepG2) using MTT viability assay, and apoptotic morphological staining which including Acridine Orange/Ethidium Bromide (AO/EB), H...
Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities
International Journal of Molecular Sciences
Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.
2018
A series of six new mononuclear Schiff base complexes, <b>1</b>–<b>6</b> of cobalt(III) of the general formula, [CoLX] or its adduct with methanol, is reported. The pentadentate Schiff base ligand (H<sub>2</sub>L) was obtained by the condensation of <i>N</i>-(3-aminopropyl)-<i>N</i>-methylpropane-1,3-diamine with 1-(2-hydroxyphenyl)ethanone (H<sub>2</sub>L<sup>1</sup>) or 1-(2-hydroxyphenyl)propan-1-one (H<sub>2</sub>L<sup>2</sup>). X stands for the pseudohalides, N<sub>3</sub><sup>–</sup>, N(CN)<sub>2</sub><sup>−</sup> , and NCS<sup>–</sup>. The complexes have been synthesized by the reaction of equimolar amounts of cobalt(II) nitrate with H<sub>2</sub>L<sup>1</sup> or H<sub>2</sub>L<sup>2</sup> in the presence of the respective pseudohalide in methanol medium. All the ...
Schiff Base Metal Complexes as Anticancer Agents
Asian Journal of Chemistry
Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.
Ife Journal of Science, 2019
Highlights • Two 3-aminopyridine derived Schiff bases were synthesized. • Six cobalt (II) complexes of the Schiff bases were synthesized. • The Schiff bases and the cobalt (II) complexes were characterized. • Antimicrobial and brine shrimps activities of the complexes and the Schiff bases were examined Two biologically active Schiff base GL1 and GL2 were synthesized in equimolar reaction of 3-aminopyridine with o-vanillin and p-vanillin. The synthesized Schiff bases were reacted with cobalt acetate, cobalt chloride or cobalt chloride with trimethylamine by using a molar ratio of Schiff base: cobalt salt as 2:1. The characterization of Schiff bases and cobalt complexes was done by UV-visible in methanol, diffused reflectance, FTIR (mid and 1 13 far), mass spectrometry studies while H NMR and C NMR were used to further characterize the Schiff bases. The FTIR results confirmed the bidentate binding of the Schiff bases with cobalt center after the formation of the complexes. The UV-visible spectra and diffused reflectance spectra data obtained were used to further investigate the electronic structure as well as the properties of Schiff bases and their cobalt complexes. On the basis of the spectral studies, distorted tetrahedral geometry has been assigned for the Co(II) complexes. The antimicrobial activities of the two Schiff bases GL1, GL2 and their cobalt(II) complexes were tested against laboratory isolated Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and one fungus strain, Aspergillus niger. The antimicrobial evaluation demonstrates significant activity of the Schiff bases and the cobalt complexes against the four known human pathogens. The brine shrimps lethality study confirmed that the compounds are concentration and geometry dependent. The studies showed the complexes were higher in biological activity than the corresponding Schiff bases.
Advances in Biological Chemistry, 2017
The synthesis and structural characterization of cobalt(II) complexes of amino acid Schiff bases was prepared from Salicylaldehyde and three amino acid (Valine, Leucine, and Isoleucine) in basic medium. The metal complexes was synthesized by treating an ethanolic solution of the ligand with appropriate amount of metal salts [1:2] [M:L] ratio. The synthesized Schiff bases and their metal complexes have been investigated on the bases of elemental chemical analysis, FTIR, electronic spectral, 1 HNMR, 13 CNMR, MS, molar conductance and magnetic susceptibility measurements. The electronic spectra of the metal complexes and their magnetic susceptibility measurements suggest octahedral structures are the probable coordination geometries for the isolated complexes. The Schiff bases and their metal complexes were preliminary scanned against various strains of microbes to study their biological effect.
Schiff base complexes as versatile pharmacophores of metallopharmaceutical interest-A review
2021
This review is mainly focused on the biological significance of Schiff base complexes. Schiff bases and their metal complexes are fascinating ligands which are synthesized from the chemical reaction between a primary amine compound and carbonyl grouping. These compounds and their metal complexes are very important as pivots in various biological systems, polymers, dyes and medicinal and pharmaceutical fields. These compounds exhibit useful biological activities such anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, antiglycation, and antidepressant activities. These molecular scaffolds are also used as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. Also, their use in birth control and food packages is outlined in this review.