original ) (raw )Award Number: DAMD17-96-1-6198 TITLE: The Role of PTHrP in Mammary Gland Development and Tumorigenesis
John Wysolmerski
2018
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Role of PTHrP in Mammary Gland Development and Breast Cancer
John Wysolmerski
Clinical Reviews in Bone and Mineral Metabolism, 2014
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Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland
Joshua VanHouten
PLoS ONE, 2011
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Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development
John Wysolmerski
1998
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Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
John Wysolmerski
Journal of Mammary Gland Biology and Neoplasia, 2013
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Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland development
John Wysolmerski
Journal of mammary gland biology and neoplasia, 1999
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Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
John Wysolmerski
Development
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Nuclear Localization of the Type 1 PTH/PTHrP Receptor in Rat Tissues
M. Kisiel
Journal of Bone and Mineral Research, 2000
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Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
John Wysolmerski
Development
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
Diego Grinman
Breast Cancer Research
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Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein
D. Goltzman
Proceedings of the National Academy of Sciences, 2008
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Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival
Miriam Falzon
Regulatory Peptides, 2009
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Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland
Jan Mol
Journal of Steroid Biochemistry and Molecular Biology, 2000
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PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target
Richard Kremer
Journal of Clinical Investigation, 2011
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Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development
Gertraud Robinson
Development
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Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation
Ricardo Moraes
Development, 2009
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The midregion, nuclear localization sequence, and C terminus of PTHrP regulate skeletal development, hematopoiesis, and survival in mice
Prosper Boyaka
The FASEB Journal, 2010
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Hormone action in the mammary gland
Cathrin Brisken
Cold Spring Harbor perspectives in biology, 2010
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Pleiotrophin (PTN) Expression and Function and in the Mouse Mammary Gland and Mammary Epithelial Cells
Thomas Knoblauch
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Progesterone receptors in mammary gland development and tumorigenesis
Biserka Mulac-Jericevic
Journal of mammary gland biology and neoplasia, 2003
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Identification of a Retinoic Acid-Inducible Element in the Murine PTH/PTHrP (Parathyroid Hormone/Parathyroid Hormone-Related Peptide) Receptor Gene
Jeanine Hendriks
Molecular Endocrinology, 1999
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Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)
Jean-pierre Cartron
Gene, 1989
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Potency of thyroid hormone analogues in suppressing prolactin-mediated mammary growth in thyroidectomized rats
Indraneel Mittra
Experientia, 1975
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Analysis of gene expression in PTHrP −/− mammary buds supports a role for BMP signaling and MMP2 in the initiation of ductal morphogenesis
John Wysolmerski
Developmental Dynamics, 2009
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P190A RhoGAP is required for mammary gland development
Jeff Settleman
Developmental Biology, 2011
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Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting
Terence Wu
Proceedings of the National Academy of Sciences, 1997
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In vitro model of parathyroid hormone-related protein secretion from mammary cells isolated from lactating cows
M. Weckmann
Domestic Animal Endocrinology, 1996
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The Hyperplastic Phenotype in PR-A and PR-B Transgenic Mice: Lessons on the Role of Estrogen and Progesterone Receptors in the Mouse Mammary Gland and Breast Cancer
Marina Simian
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Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice
Kenneth Korach
1997
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Parathyroid Hormone–Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal CarcinomaIn situ
Robin Anderson
Cancer Research, 2009
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Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
Mrutyunjaya S Hiremath
2012
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Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma
Vincent Goffin
Journal of Endocrinology, 2006
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Midregion Parathyroid Hormone-Related Protein Inhibits Growth and Invasion In Vitro and Tumorigenesis In Vivo of Human Breast Cancer Cells
Javier Turnay
Journal of Bone and Mineral Research, 2001
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Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
Biserka Mulac-Jericevic
Proceedings of the …, 2003
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