Efficacy of Centrifuged Liquid-Based Cytology over Conventional Cytology in Oral Squamous Cell Carcinoma: A Diagnostic Augmentation (original) (raw)

2015

Abstract

Background: Oral exfoliative cytology is the cost effective and perhaps the best approach for the initial evaluation and diagnosis of the oral lesion. Centrifuged liquid-based cytology (CLBC) offers high-quality smears compared to the conventional cytology enhancing sensitivity and quality of smear with limited available resources. Aims: The aim was to determine the efficacy of CLBC over conventional cytology technique by quantitative analysis of smears of patients with oral squamous cell carcinoma (OSCC). Materials and Methods: In this prospective comparative study, smears were obtained from lesions of OSCC with a soft toothbrush after obtaining prior written consent. One smear was made using the conventional technique and another with the CLBC. For CLBC, sample was centrifuged with a prepared reagent following which a smear was made from the cell pellet. Both the smears were stained by Papanicolaou method. Smears from both the techniques were analyzed with respect to cellularity, ...

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