Microalbuminuria in Diabetic Patients in the Bamenda Health District (original) (raw)
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Journal of Diabetes Research
Background. Diabetic nephropathy (DN) is a common finding in diabetic patients. Microalbuminuria is the earliest clinical evidence of DN. Early detection of microalbuminuria is very important; it allows timely interventions to prevent progression to macroalbuminuria and later end-stage renal disease (ESRD). Objectives. To determine the prevalence of microalbuminuria in diabetic patients and establish its association with traditional serum renal markers in assessment of incipient nephropathy. Methods. This cross-sectional study involved 140 participants with diabetes mellitus (DM) attending the diabetic clinic of Mbarara Regional Referral Hospital. Questionnaires were used to obtain participant data after obtaining written informed consent. Data collected included: age, sex, level of education, history of smoking and alcohol consumption, hypertension, body mass index, family history, and duration of DM. Morning spot urine samples were collected from each participant and blood drawn f...
2021
Background Regular screening for microalbuminuria among type 2 diabetes patients is less common in most low-income countries while it is an early marker of diabetic nephropathy and cardiovascular complications. Objective This study aims to assess the need for regular screening for microalbuminuria among type 2 diabetes patients. Methodology with cross-sectional approach, 124 diabetic patients were recruited at Muhimbili National Hospital, in Tanzania; their age, gender, body mass index, fasting blood sugar levels (by Accu Chek Active Glucometer), random urine albumin levels (by Microalbumin 2-1 Combo Test Strips), and the duration of diabetes were recorded. Results The study indicated that 62.1% of the participants were microalbuminuric while 2.4% were macroalbuminuric. The risk of microalbuminuria was 4.55 higher in patients aged 60-69 years (95% CI: 1.32-16.51), and 17.4 times higher in patients aged 70 and above (95% CI: 1.49-202.86) compared to individuals aged below 50 years. P...
2007
OBJECTIVE To evaluate the prevalence and predictors of microalbuminuria in diabetics in Kumasi, Ghana. DESIGN Prospective, cross-sectional study of diabetic patients. SUBJECTS Patients with diabetes, 20 to 78 years of age. MAIN OUTCOME MEASURES Microalbuminuria METHODS All patients (109) attending an outpatient diabetic clinic at the Komfo Anokye Teaching Hospital Diabetes Centre in Kumasi, Ghana from January to July 2005 were enrolled in the study. RESULTS The mean overall age of the cohort was 54.1 +/- 10.9 years, and 28% were male. The proportion of subjects who had microalbuminuria was 43.1% (n=47). The median duration of diabetes before development of microalbuminuria was 10 years. Duration of diabetes, blood urea nitrogen, serum concentration of creatinine, and triglyceride were significantly higher in patients with microalbuminuria (P<.05). Urinary potassium concentration and fractional excretion of potassium were also significantly higher in the patients with microalbumin...
BMC nephrology, 2007
The prevalences and risk factors of microalbuminuria are not full described among black African diabetic patients. This study aimed at determining the prevalence of microalbuminuria among African diabetes patients in Dar es Salaam, Tanzania, and relate to socio-demographic features as well as clinical parameters. Cross sectional study on 91 Type 1 and 153 Type 2 diabetic patients. Two overnight urine samples per patient were analysed. Albumin concentration was measured by an automated immunoturbidity assay. Average albumin excretion rate (AER) was used and were categorised as normalbuminuria (AER < 20 ug/min), microalbuminuria (AER 20-200 ug/min), and macroalbuminuria (AER > 200 ug/min). Information obtained also included age, diabetes duration, sex, body mass index, blood pressure, serum total cholesterol, high-density and low-density lipoprotein cholesterol, triglycerides, serum creatinine, and glycated hemoglobin A1c. Overall prevalence of microalbuminuria was 10.7% and mac...
Journal of Obesity and Weight-loss Medication, 2018
Background-Microalbuminuria is an early marker of nephropathy, cardiovascular diseases and severe ocular morbidity in adults with diabetes mellitus. This subclinical condition is associated with high morbidity and mortality. Microalbuminuria precedes the development of overt diabetic nephropathy by 10-14 years. At this stage, one can reverse diabetic nephropathy or prevent its progression. Unfortunately, tests to detect microalbuminuria in diabetics are not routinely done in Uganda. This study sought to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in the National Referral Hospital in Uganda. Methods-In this cross-sectional study conducted between June 2014 and January 2015, we recruited 175 newly diagnosed adult diabetic patients. Information on patients' sociodemographics, biophysical profile, blood pressure measurement, biochemical testing and echocardiographic findings was obtained for all the participants using a pre-tested questionnaire. Microalbuminuria was defined as Albumin to Creatinine Ratio (ACR) between 30 and 299 mg/g. Bivariate and multivariate logistic regression analyses were used to investigate the association of several factors with microalbuminuria. Results-Of the 175 patients recruited, males were 90 (51.4%) and the mean age was 46 ± 15 years. Majority of patients had type 2 DM 140 (80.0%) and the rest had type 1 DM 35 (20.0%). The mean HbA1C was 13.9 ± 5.3%. Mean duration of diabetes was 2 months. Prevalence of This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Indian Journal of Endocrinology and Metabolism, 2013
To assess the prevalence of persistent microalbuminuria (MAU), its clinical correlates by dip stick method, its predictive value for potential kidney disease and the utility of this test as objective cue for health care seeking behavior in adult Indian patients with type 2 diabetes mellitus. Materials and Methods: Approximately 400,000 patients shall be enrolled in this multicentric, cross sectional study. Patients meeting eligibility criteria shall be screened for MAU through urine dipstick test using random daytime single spot urine specimen. Result shall be expressed either positive or negative based on the presence or absence of albumin in the urine and will be correlated with the corresponding random blood glucose. Height, weight, waist circumference and blood pressure shall be assessed. There will be three visits with a minimum interval of 28 days between two visits, to be completed within 180 days, and at least two of three urine tests measured in this period must show elevated albumin levels to diagnose MAU. Conclusion: Detection of MAU through the dipstick method is postulated to be a rapid, reliable test for early detection of diabetic nephropathy, which, in turn will help the physician to plan treatment strategy. Further, it will help to identify the disease burden on the individual and society, and may serve as an objective cue for improved health care seeking behavior, as well as a catalyst for health policy change.
Prevalence of microalbuminuria among adults with Type 2 Diabetes mellitus at OOUTH, Sagamu
Annals of Health Research
Background: Diabetes mellitus is a serious global epidemic. The menace of this chronic disease is attributable to its chronic complications which threaten both the world economy and life expectancy, especially in Sub- Saharan Africa. Nephropathy is a complication of Diabetes mellitus and a leading cause of End Stage Renal Disease. Objectives: To determine the prevalence of microalbuminuria as well as the effects of co-morbidities on the pattern of microalbuminuria among adults with Type 2 Diabetes mellitus. Methods: A total of 325 adults with Diabetes mellitus and 100 controls without Diabetes mellitus were studied. The subjects with diabetes were classified into four groups ([i] diabetes only, [ii] diabetes with hypertension, [iii] diabetes with obesity and [iv] diabetes with hypertension and obesity). Urinary protein, microalbuminuria, fasting plasma glucose and Glycated Haemoglobin (HbA1c) were measured using standard methods. Results: The overall prevalence of microalbuminuria ...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2023
Background: Microalbuminuria (MAU) is considered the earliest sign of diabetic nephropathy among diabetes patients. In order to effectively manage diabetic nephropathy and its consequences early, detection of microalbuminuria as soon as possible, especially for diabetes patients, is critical. Therefore, the present study aimed to determine the pooled prevalence of microalbuminuria among diabetes patients in Africa. Methods: Electronic databases such as Google Scholar, PubMed, African Journals Online, Web of Science, Cochrane Library, EMBASE, and ResearchGate were searched for articles and grey literature. The STATA version 14 software was used to conduct the meta-analysis. I 2 and Cochran's Q test were employed to assess the presence of heterogeneity between studies. Due to the presence of heterogeneity, a random effect model was used. The publication bias was assessed using the symmetry of the funnel plot and Egger's test statistics. Moreover, subgroup analysis, trim and fill analysis, and sensitivity analysis were also done. Results: The overall pooled prevalence of microalbuminuria among diabetes patients in Africa was 37.11% (95% CI 31.27-42.95). Substantial heterogeneity was observed between studies, with I 2 values of 94.7%. Moreover, this meta-analysis showed that the pooled estimate of microalbuminuria among type 1 and type 2 diabetes patients was 35.34% (95% CI: 23.89-46.80, I 2 =94.2), and 40.24% (95% CI: 32.0-48.47, I 2 =94.9) respectively. MAU, on the other hand, was more common in people with diabetes for more than 5 years 38.73% (95% CI: 29.34-48.13) than in people with diabetes for less than 5 years 31.48% (95% CI: 18.73-44.23). Conclusion: This systematic review and meta-analysis found a high prevalence of microalbuminuria among diabetes patients. As a result, early detection of microalbuminuria is critical for preventing and treating microvascular complications such as diabetic nephropathy and the onset of end-stage renal disease.
Microalbuminuria and Status of diabetic nephropathy in low socioeconomic sect of Karachi
European Journal of Biotechnology and Bioscience, 2015
Microalbuminuria, an established biomarker of nephropathy in diabetes, is often ignored in the lower socioeconomic sect of our society. The aim of this study was to investigate the status of nephropathy with reference to microalbuminuria in diabetics and understanding of these complications in this sect of Karachi. 90 Patients (aged 30–76 years) with type 2 diabetes were selected from diabetic clinic. Albumin/creatinine ratio was determined. Urine samples were divided into three groups according to albumin-to-creatinine ratio; normoalbuminuria, microalbuminuria and macroalbuminuria with UACR <30mg/g, >30mg/g and >300mg/g respectively. The subjects had no Urinary Tract Infection. Details regarding diabetes and hypertension were recorded through a structured questionnaire after informed consent. Glucose was estimated in blood and Microalbuminuria, Proteinuria and glycosoria were anaylzed using dipstick (Roche) in urine samples.Out of 90 Diabetic patients 8.9% had hypertension...
Microalbuminuria in Young Sudanese Patients with Type 1 Diabetes
Annals of Saudi Medicine, 1993
Overnight urinary albumin excretion (UAE) was measured in 51 patients, nine to 18 years old, with type 1 (insulin-dependent) diabetes mellitus and in 22 healthy subjects using radioimmunoassay. Thirteen diabetic patients (25.5%) had microalbuminuria defined as UAE rate between 20 and 200 (μg/min. Eleven of these patients were over 13 years of age. This gives a frequency of microalbuminuria of 42% (11/26) in the diabetic children and adolescents in the age group 14-18 years. UAE rate was positively correlated with both age at diagnosis and duration of diabetes. Arterial blood pressure, systolic and diastolic, glycosylated hemoglobin (HbA 1c) and insulin dosage U.kg-1.day-1 were significantly higher (P<0.001) in the diabetic patients with microalbuminuria compared to the diabetic patients with normal UAE rate. Retinal changes were also more common in the microalbuminuric diabetic patients than in the diabetic patients without microalbuminuria (P<0.01). This study has revealed a high prevalence of microalbuminuria in young Sudanese patients with type 1 (insulin-dependent) diabetes mellitus and emphasized the importance of routine screening of diabetic children after the age of 12 years. Despite the marked reduction in the incidence of diabetic nephropathy that occurred in recent decades, it is estimated that between 30% to 35% of the patients with type 1 (insulin-dependent) diabetes mellitus are still at risk of developing this complication [1]. Nephropathy is regarded as the most serious late diabetic complication because it is associated with 100 times greater risk of mortality than in the background population [2]. The median survival period of diabetic patients after onset of overt albuminuria was reported as less than 10 years [3]. In 1963, a sensitive method for detecting urinary albumin in low concentrations was described [4], and since then, many studies have been performed to establish the rate of urinary albumin excretion (UAE) that is predictive of later nephropathy. It was concluded from several reports that a cutoff level of 20 μg/min would include almost 80% of the patients at risk [5-7]. A rate of UAE between 20 and 200 (μg/min was therefore defined as microalbuminuria and is thought to signify incipient nephropathy [8]. Previous studies have shown recognizable variations in the prevalence of microalbuminuria in diabetic patients and have been inconclusive regarding the relationship between UAE and metabolic control [9-12]. The aim of the present study was to determine the prevalence of at risk values of UAE in young Sudanese diabetic patients and to explore its relation to age and glycemic control. Subjects and Methods Subjects The subjects were selected from the children and adolescents with type 1 diabetes who regularly attend the diabetic clinic at the University Hospital in Khartoum, Sudan. The patients who were between nine and 18 years of age and who had the disease for more than one year (62 children) were invited to participate in the study. Thirty healthy nondiabetic schoolchildren, matched for age and sex, were also invited to participate as a control group. All the selected patients were on insulin since the day of diagnosis and nonketotic at the time of investigation. None of these patients were taking any other drug(s) nor had a history of cardiac or nondiabetic renal disease. Methods The UAE was measured in a single, timed overnight urine collection. In accordance with the given instructions, all subjects passed urine immediately before going to bed, discarded this sample and recorded the time. The urine