Cellular Energetical Actions of "Chemical" and "Surgical" Vagotomy in Gastrointestinal Mucosal Damage and Protection: Similarities, Differences and Significance for Brain-Gut Function (original) (raw)

The significant difference in the long lasting actions of surgical and chemical (atropine) vagotomy in peptic ulcer patients has been known for half century. Authors establishing human clinical pharmacology aimed to know more details of the acute and chronic effects of surgical vagotomy and atropine treatment on gastrointestinal mucosal biochemisms and their actions altered by bioactive compounds and scavengers. The observations were carried out in pylorus-ligated vagotomised or atropine treated rats under various experimental ulcer models, together with application of various mucosal protecting compounds. 1. No changes were obtained in the cellular energy systems (ATP, ADP, AMP, cAMP, "adenylate pool", "energy charge" of stomach in rats after surgical vagotomy in contrast to those produced by only chemical vagotomy; 2. The effects of the gastric mucosal protective compounds (atropine, cimetidine, prostaglandins, vitamin A, β-carotene, capsaicin) disappeared afte...