Dermatofibroma with granular cells (original) (raw)
Related papers
Granular Cell Dermatofibroma: When Morphology Still Matters
Dermatopathology, 2021
Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.
Granular cell dermatofibroma: A potential diagnostic pitfall
Dermatology Reports
Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumours. Many variants of dermatofibromas have been described and knowledge of these variations is important to avoid a misdiagnosis of a possibly more aggressive tumour. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for a correct nosographic classification. We report on the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74- year-old woman.
Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall
Polish Journal of Pathology, 2016
Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Immunohistochemical analysis with antibodies against CD31, CD56, CD68, CD117, S-100 protein, inhibin, calretinin, EMA, p53 and MIB-1 was performed, showing expression of CD56, CD68, S-100 protein, inhibin and calretinin. The diagnosis of atypical dermatofibroma-like GCT was made.
Journal of the European Academy of Dermatology and Venereology : JEADV, 2015
Dermatology literature lacks a study investigating both histopathological and dermatoscopic features of dermatofibroma. To analyse histopathological, dermatoscopic and digital microscopic features of dermatofibromas. Two hundred dermatofibromas and 190 patients were included and retrospectively evaluated. Nine histopathological and ten dermatoscopic patterns were used to classify the lesions. We identified four different types of dermatofibroma in digital microscopy. The mean age of the patients was 42.18 ± 13.72 years. Dermatofibroma was more common in females (67%) and the male to female ratio was 1 : 1.97. The most common location was leg (41%). The most frequent histopathological variant was fibrocollagenous type (49%). Grenz zone was the most common histopathological finding (89%). The most frequent digital microscopic type was type 1 (63%). We found that palisading variant displayed only pattern 6 in dermatoscopy and cellular variant showed type 3 significantly in digital micr...
Sclerotic fibroma-like dermatofibroma: an uncommon distinctive variant of dermatofibroma
Histology and histopathology, 2005
Dermatofibroma (DF) is a common benign cutaneous tumor with many variants based on alterations in the morphology and composition of its diverse elements. One very infrequent type is sclerotic fibroma-like DF (SF-DF). We report 7 new cases of SF-DF. In addition, their main clinicopathological and immunohistochemical features were compared with 14 unselected common DFs and with 3 sclerotic fibromas (SFs). Microscopically, the 7 cases of SF-DFs showed an unencapsulated, well-circumscribed, hypocellular central nodule with thick collagen bundles arranged in a storiform pattern with prominent clefts. The overlying epidermis was attenuated. The periphery of this nodule was more cellular with histopathologic features of common DF. The 7 SF-DFs patients were 4 women and 3 men with a mean (+/-SD) age of 44.8 (+/-15.5) years. These 7 patients were younger than those suffering from SFs [71.0 (+/-17.3) years; (p=0.04)] and older than those presenting common DFs [30.5 (+/-12.3) years; (p=0.03)]....
Variants of dermatofibroma - a histopathological study
Anais Brasileiros de Dermatologia, 2014
Several variants of dermatofibroma have been described. They are essentially distinguished by their clinical and histopathological features. To review the mainfeaturesof these variants, a retrospective study of skin biopsies and tissue excisions of dermatofibromasperformed in the dermatology and venereology service at the Hospital Garcia de Orta between May 2007 and April 2012 was carried out. During that period, 192 dermatofibromas were diagnosed in 181 patients, the lesions being more common in women. Median age of the study population was 48 years. The most common lesion site was the limbs (74% of patients). The histopathological types found were common fibrous histiocytoma (80%) and the aneurysmal (5.7%),hemosiderotic (5.7%), epithelioid (2.6%), cellular (2.1%), lipidized (2.1%), atrophic (1.0) and clear cell (0.5%) variants. Based on these findings, this review focuses on the clinical and histological features of the various variants of dermatofibroma in terms of their clinical presentation, distinct histopathological features, differential diagnosis and prognosis.
Diagnostics
Dermatofibroma (DF) or fibrous histiocytoma is one of the most frequent benign cutaneous soft-tissue lesions, characterized by a post-inflammatory tissue reaction associated with fibrosis of the dermis. Clinically DFs have a polymorphous clinical aspect from the solitary, firm, single nodules to multiple papules with a relatively smooth surface. However, multiple atypical clinicopathological variants of DFs have been reported and, therefore, clinical recognition may become challenging, leading to a more burdensome identification and sometimes to misdiagnosis. Dermoscopy is considered an important tool in DFs diagnosis, as it improves diagnostic accuracy for clinically amelanotic nodules. Although typical dermoscopic patterns are most frequently seen in clinical practice, there have also been some atypical variants described, mimicking some underlying recurrent and sometimes harmful skin afflictions. Usually, no treatment is required, although an appropriate work-up may be necessary ...
Hyperpigmented Nodular Dermatofibroma: Two Cases Report and Brief Literature Review
Open Access Macedonian Journal of Medical Sciences
BACKGROUND: Dermatofibroma (DF) is a common benign skin tumor (Benign Fibrous Histiocytoma) that mostly affects the extremities with a tendency to occur more often in older females than males. It usually presents as a slow growing small brown dome shape papule on the extremities. DF has a chronic nature and can sometimes regresses spontaneously. Dermoscopy is essential in the evaluation of DF to help differentiate it with other skin tumors. The gold standard evaluation for diagnosis of DF is biopsy with histopathologic examination. Removal of DF is often due to cosmetic factors, with surgical excision being the preferred method for removal. DF has an excellent prognosis. CASE REPORT: We present two case reports of women with hyperpigmented nodules on the lower extremity. Dimple sign was positive. From dermoscopic study showed a pigment network and central white patch pattern. On histologic examination revealed proliferation of fibroblast such as spindle cells as a storiform pattern ...