Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure (original) (raw)

Inhaled nitric oxide (NO) is a common treatment for persistent pulmonary hypertension of the newborn (PPHN), but its potential pulmonary toxicity in term infants undergoing severe respiratory failure remains a concern. This study evaluates airway specimens from term infants treated with inhaled NO to assess markers of toxicity. Key findings include the detection of nitrotyrosine in prolonged ventilation cases, while other inflammatory cytokines and lipid peroxidation products did not show significant changes due to NO exposure. Results highlight the need for vigilance regarding potential toxic effects of endogenous NO in neonatal care.