Effect of body weight on gentamicin pharmacokinetics in neonates (original) (raw)

Clinical pharmacy

Abstract

The pharmacokinetics of gentamicin in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) newborn infants were compared in a prospective study. Serum gentamicin concentrations were drawn just before (trough) or after (peak) the third or fourth dose of gentamicin sulfate 2.5 mg/kg given as a 30-minute i.v. infusion every 12 hours to 11 LGA and 12 AGA infants. Peak (Cmax) and trough ( Cmin ) serum concentrations, elimination rate constants (k), volumes of distribution (V), and clearances (CL) were compared between the AGA and LGA groups and within the LGA group between obese (n = 6) and nonobese (n = 5) infants. The serum gentamicin concentrations achieved in the LGA infants were similar to those in the AGA infants, with Cmin values less than 2 micrograms/ml and Cmax values of 4-7 micrograms/ml. The mean pharmacokinetic variables determined were consistent with literature values reported for AGA infants. No significant differences in these variables were observed...

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