A Clinicopathologic Study of Seven Cases of Orbital Solitary Fibrous Tumours (original) (raw)
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Orbital solitary fibrous tumor: report of two cases and literature review
Japanese Journal of Ophthalmology, 2003
Background: Solitary fibrous tumor (SFT) is a rare, benign, and very uncommon lesion in the orbit. Because of its complex and variable clinical and histological appearance the SFT is often misdiagnosed. Cases: Two new cases of orbital SFT are reported, one in a man and the other in a woman, both unilateral and in the superomedial orbit. Observations: Clinical and tomographical evaluations were conducted and the lesions were excised. The histological evaluation showed the tumors were composed of spindle-shaped cells within collagen bundles and vascular channels. Immunohistochemical staining was positive for CD 34 and negative for S-100 protein. Conclusion: Immunohistochemical study is an important adjuvant in determining the SFT diagnosis. Long-term follow-up is necessary because of the possibility of SFT recurrence after excision. Jpn
Orbital solitary fibrous tumor: A rare clinicopathologic correlation and review of literature
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013
Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site. It is mostly noted to arise from mesenchymal structures like pleura and peritoneum. The diagnosis of orbital SFT cannot be made with certainty on clinical or radiological evaluation alone and requires immunohistochemical studies for confirmation. Orbital SFT's usually show an indolent clinical course and a complete cure can usually be achieved with complete resection. We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a brief review of literature.
A rare case report of orbital malignant solitary fibrous tumor
IP innovative publication pvt. ltd, 2019
Purpose: Orbital Solitary Fibrous Tumor (SFT) is a rare spindle cell neoplasm of mesenchymal origin.1 We describe the clinical presentation, radiological features, pathological features of a 23yr old female patient with orbital malignant SFT. Observation: We report a case of Malignant Orbital Solitary Fibrous Tumor of the orbit in a 23yr old female who presented with painless unilateral proptosis of the left globe noticed by her in the last 1 month. Computed Tomography scan showed a well-defined homogeneous enhancing soft tissue density in superior and extraconal compartment, with no evidence of bony erosion or calcification. Enbloc tumor resection confirmed SFT based on histopathological and immunohistochemistry studies. Microscopic examination showed a highly cellular tumor, moderate amount of pleomorphism and increased mitosis (>4/10). Immunohistochemistry studies confirmed diagnosis as tumor was diffuse positivity with CD34, BcL2 positive, STAT6 positive with ki 67 high i.e. a 9-10% proliferative index in hot spot areas. Desmin, CD99, S100 and EMA was negative. Patient subsequently was also given External Beam Radiotherapy. Conclusion: Solitary Fibrous Tumors are rare tumor, which should be included in differential diagnosis of soft tissue tumor of the orbit. Combination of Computed Tomography scan, histological examination and immunohistochemical markers provide an accurate diagnosis. Complete surgical resection along with long term follow up is essential.
Annals of Saudi Medicine, 2020
BACKGROUND: Solitary fibrous tumors (SFT), formerly called heman- giopericytoma, are rare tumors derived from mesenchymal cells origi- nally described in the pleura, but these tumors may affect extraserosal tissues including the lacrimal gland and orbit. OBJECTIVE: Conduct a multi-centered clinical, radiological and histo- pathological analysis of 17 orbital SFT cases. DESIGN: A retrospective case series. SETTING: Three eye centers in two countries. PATIENTS AND METHODS: The data collected from the charts of 17 adult patients presenting with tissue diagnosis of orbital hemangioperi- cytoma or SFT from January 2003 to December 2018 included demo- graphics, clinical imaging and histopathological information including immunohistochemical (IHC) characteristics. MAIN OUTCOME MEASURES: The demographic characteristics, clinical presentation, and histopathological patterns or variants of SFT were analyzed. SAMPLE SIZE: 17 adult patients. RESULTS: Mean age was 45 years (range 23-80 years). Male to fe- male ratio was 3:1. The right eye was affected in 12 (70.5%) patients. Commonest presentation was proptosis in 13/17 (76% of patients). Other symptoms were impaired motility (29%) and ptosis (11%). Lesions mostly affected the medial orbit (35%), then orbital apex in 11%. The histopathological classic pattern-less variant was the commonest. One case with aggressive behavior, multiple recurrences and atypical fea- tures was encountered. Immunohistochemical (IHC) markers used in- cluded CD34 expression in all cases, Bcl-2 expression in 10/11, CD99 in 9/9 and Vimentin in 4/4. STAT6 was used in 2 cases. CONCLUSIONS: SFTs are rare tumors affecting the orbit in both gen- ders equally in their mid-forties, but showed male predominance in our analysis with a predominant classic histopathological pattern. Tissue diagnosis is essential and requires IHC studies for confirmation. LIMITATIONS: Sample size is relatively small owing to the rarity of this tumor in the orbit. CONFLICT OF INTEREST: None.
Recurrent Orbital Solitary Fibrous Tumor in a 12-Year-Old
Ocular Oncology and Pathology, 2016
plete gross tumor excision, this case represents the youngest individual with a recurrence to the authors' knowledge. This case of rapid recurrence may have been due to tumor seeding at the time of initial biopsy or other factors. This case increases the known spectrum of orbital solitary fibrous tumors.
Solitary fibrous tumour of the orbit: clinical and histological evidence
European Journal of Plastic Surgery, 2004
Solitary fibrous tumour (SFT) is rarely found in the orbit; it can occur within a wide age range (14-80 years). A case of a 59-year-old man with unilateral exophthalmos is presented. After CT and MRI investigations, the cause was seen to be an orbital mass that, after surgical removal, was diagnosed histologically as a solitary fibrous tumour. In the orbit, the SFT has a histological appearance identical to that of homonymous pleural lesion. It is characterized by alternating hypercellular and hypocellular areas, the collagen bundles having a keloid-type quality. Immunohistochemically, it showed a strong and widespread reactivity for CD68 and CD34. Correct diagnosis of this infrequent neoplasm needs not only clinical observation but also requires radiological examination (CT, MRI) and, above all, histological assessment. Various primary mesenchymal tumours of vascular and fibrohistiocytic type can mimic the symptoms of SFT, thus only the immunohistochemical profile and the ultrastructural features of the lesion allows it to be diagnosed definitively.
Solitary Fibrous Tumor of the Orbit: A Case Series
Orbit, 2008
Purpose: Solitary fibrous tumor (SFT) occurs rarely in the orbit. We present four such cases, representing one of the largest case series reported to date of this rare orbital tumor. Method: The four patients ranged from ages 20 to 50, all of whom presented with lid swelling or bulging in the involved eye. All four patients underwent CT scan to confirm the diagnosis of an orbital mass, which was then excised. Results: The tumors of all four specimens contained spindle-shaped cells with bland nuclei and rare mitotic figures. They all stained positively with CD34 and vimentin. Resection margins were positive in two of the four cases. One of these cases demonstrated residual tumor on followup CT scan, which remained unchanged at one-year follow-up. No evidence of residual tumor was found in the other three cases, despite one having malignant pathology. Conclusion: SFT is a rare and generally benign tumor of the orbit. Immunohistochemical testing with CD34 is necessary to confirm the diagnosis. Although en bloc tumor resection is the definitive treatment, residual tumor may remain stable for some time. However, this must be followed closely if complete resection is not carried out.
Survey of Ophthalmology, 2003
Solitary fibrous tumor of the orbit is a rare spindle cell neoplasm. There are 42 cases of solitary fibrous tumor of the orbit available in the literature. We present six more cases of orbital solitary fibrous tumors, which presented to our institute between 1999 and 2001. We highlight the need for clinical recognition of these tumors as a distinct entity and inclusion of this tumor in the etiological differential diagnosis of well-circumscribed orbital lesions presenting as unilateral proptosis in both children and in adults. The diagnosis may be suspected based on radiological features supported by histopathologic and immunohistochemical study. The strong CD34 immunoreactivity of this tumor supports its diagnosis. Complete surgical resection is the most important prognostic factor of this tumor. (Surv Ophthalmol 48:544-554, 2003. Ć
Histologically malignant solitary fibrous tumor of the orbit
Neurochirurgie, 2006
Histologically malignant solitary fibrous tumor of the orbit L. M ASCARENHAS , M. L OPES , A. M. D UARTE , H. R OMÃO , M. H ONAVAR , M. R ESENDE , A. R OCHA V AZ (Neurochirurgie, 2006, 52 , 415-418 ) .