Hearing status in neonatal hyperbilirubinemia by auditory brain stem evoked response and transient evoked otoacoustic emission (original) (raw)
Related papers
2011
Hyperbilirubinemia at neonatal period is one of the major deteriorating factors of the auditory system. If left untreated, it may cause certain cerebral damage. This study aims to evaluate the impact of hyperbilirubinemia on the hearing of neonate. This study was conducted on 35 newborn babies with jaundice (bilirubin more than 20 mg/dL). Auditory brainstem response (ABR) and transient evoked otoacoustic emission (TEOAE) tests were performed, after treatment and one year after. ABR test results indicated that 26 children (74.3%) had normal hearing but 9 (25.7%) suffered from an impairment. As for TEOAE test, 30 children (85.7%) passed whereas the remaining (14.3%) seemed to be failures. The comparative results of the two tests pointed to autonomic neuropathy /autonomic dysreflexia symptoms in 5 babies. Due to the high incidence of Autonomic neuropathy/autonomic dysreflexia among hyperbilirubinemic babies, screening in this regard seems reasonable. Our result emphasizes the necessity...
A study of brainstem evoked response audiometry in term neonates with hyperbilirubinemia
International Journal of Contemporary Pediatrics, 2016
Background: Brainstem evoked response audiometry (BERA) has been one of the non-invasive methods to identify the hearing abnormalities in the newborn. This study was done to determine the Incidence of hearing abnormalities during hyperbilirubinemia and to assess the Correlation of high bilirubin levels with abnormal BERA finding in the study population. Methods: This was a longitudinal observational study comprising of 54 term babies with a mean gestational age of 38.1wks which also included 10 term low birth weight babies. Babies selected for the study had hyperbilirubinemia (>15mg/dl) due to various causes in a tertiary care hospital in Bangalore city. BERA was done in all these babies separately in the both ears using 40db and 80db stimuli at birth, 1st month and 3rd month. Consent was obtained before the start of the study. Student t-test was applied wherever necessary to analyze the data. Results: Mean age of appearance of jaundice was 5.2 days (4-7 days). Abnormal Auditory Brain Response (ABR) changes were seen in 28 (51.9%) babies at birth, 19 infants (37%) at 1st month and 7 (13%) at 3rd month during follow up. Conclusions: Hearing loss due to hyperbilirubinemia is a transient phenomenon, which reverts back to normal gradually, with only a small percentage going for permanent damage.
Auditory site of lesion in infants suffering from hyperbilirubinemia by using ABR and TEOAEs
Audiology, 2006
Background and Aim: Hyperbilirubinemia is one of the most common abnormalities during the neonatal period. Approximately 60% full-term and 80% preterm neonates suffer from hyperbilirubinemia. Hearing loss is one of the most prevalent side-effects of hyperbilirubinemia. This happens when the serum concentration of indirect bilirubin increases dramatically. The main purpose of this study is to evaluate the hearing status and to diagnose the probable site of lesion in affected children. Materiads and Methods: In this cross-sectional study, 33 newborn to two year old subjects uffering from hyperbilirubinemia were evaluated using auditory brainstem response (ABR) and transient evoked otoacoustic emissions (TEOAE) tests In the Audiology department of the Faculty of Rehabilitation Sciences Iran University of Medical Sciences sampling method was accessible. Results: 21% of the subjects had severe to profound hearing loss and 9% of subjects had mild to moderate hearing loss. In 51% of the subjects there was no response to ABR and TEOAE tests indicating cochlear and/or retrocochlear lesion. The other 15% manifest only abnormal ABR test indicating the presence of the auditory neuropathy. Conclusion: TEOAEs test has its own limitations in these subjects, that is the hearing status of such patients can not be completely evaluated by using just TEOAE test. Therefore, to detect hearing loss both ABR and TEOAE tests must be performed in these subjects.
Brainstem auditory evoked responses (BAER) were longitudinally recorded prospectively in 18 term infants with neonatal hyperbilirubinemia (NHB) (total serum bilirubin >15 mg/dl). Seven neonates had abnormal BAER. Wave complex IV-V was absent in eight recordings in NHB group while they were normal in the control group (p <0.001). Prolongation of latency of waves I and V and interwave conduction time (wave I-V) occurred in jaundiced infants especially when unconjugated serum bilirubin level rose above 22 mg/dl. The abnormalities in BAER reversed to normal in all seven neonates after exchange blood transfusion indicating transient nature of bilirubin toxicity to the brain. All seven neonates in the study and control group had normal hearing, development quotient and were free of neurological sequelae on follow up for one year.
International Journal of Pediatrics, 2014
Introduction: Hyperbilirubinemia is one of the most common cause of congenital sensory neuronal hearing loss. These patients are screened by auditory brainstem response (ABR) test at bilirubin levels higher than 1% of gestational weight. Aim of this study is to determine whether hyperbilirubinemia less than 1% of gestational weight could induce hearing loss and abnormal auditory brainstem response (ABR). Materials and Methods: In this case control study the outcome of ABR test in children younger than 3 years old with a history of term delivery and hyperbilirubinemia (bilirubin level less than 1% of gestational weight) were compared with the control group without hyperbilirubinemia matched for age and gender. Results: Mean ABR amplitude (wave I, V) were significantly prolonged in neonates with jaundice compared with controls (P 0.6% gestational weight was 2.25 with 95% confidence intervals (CI) (1.44-3.89 and p=0.02). Conclusion: Our study showed a relevant association between bilir...
Medeniyet Medical Journal
The aim of this study was to investigate the long-term effects of hyperbilirubinemia on neurological and hearing function in otherwise healthy term newborns with neonatal indirect hyperbilirubinemia. Method: This study was performed prospectively in 41 term newborns hospitalized for indirect hyperbilirubinemia. Patients with no signs of hemolysis were categorized in 3 groups based on stabil levels as sTB <20 mg/dl, 20-24.9 mg/dl, and =>25 mg/dl. Patients with total bilirubin level =>20 mg/dl and hemolytic disease were classified as the fourth group. The relationship between maximum sTB level, duration of exposure to sTB levels >20 mg/dl and etiology of jaundice with neurological and auditory functions was investigated. Detailed neurological examination, Denver II developmental screening test and hearing tests (otoacoustic emissions, OAE and auditory brainstem responses, ABR) were performed to all patients between 18-24 months of age. Results: Neurodevelopmental disorder was found in 5 (12.2%) patients. Hemolytic disease was detected in two of these patients. Hearing loss was found in 4 (9.8%) of the patients. Two of these patients had auditory neuropathy spectrum disorder and the other two had cochlear hearing loss. The sTB levels of all these patients were above 25 mg/dl. No neurological disorder or hearing loss was found in the patients who had stabil of <25 mg/dl. Exposure time to sTB levels above 20 mg/dl was significantly longer in patients with neurological dysfunction and pathologic ABR results (p:0.007, p:0.007; p<0.05). Conclusion: This study demonstrates that kernicterus may develop in term newborns with severe hyperbilirubinemia (sTB>25 mg/dl) without any finding of significant hemolysis. Not only the bilirubin level but also the duration of exposure to high bilirubin levels may be effective in the development of bilirubin neurotoxicity. The high rate of hearing loss in our patients emphasizes the importance of screening for infants with severe hyperbilirubinemia using comprehensive auditory evaluation for early diagnosis of possible hearing loss.
Brainstem evoked response auditory in healthy term neonates with hyperbilirubinemia
Paediatrica Indonesiana, 2010
Background Bilirubin in healthy term neonates, especially free bilirubin (Bf), could enter brain cell and cause damage perceived by brainstem evoked response auditory (BERA). Studies identify that Bf is more associated to abnonnal BERA than total bilirubin is. Currently, phototherapy is perfonned in neonates with total bilirubin > 15 mg/dL. However, in developing countries where observation could not be done optimally, neonates \\lith totalbilirubin> 12 mg/dL will be subject for phototherapy.Objectives To determine the association between total bilirubin > 12 mg/dL and BERA abnonnalities in healthy tenn neonates, and the value of total bilirubin and free bilirubin that initiate abnonnal BERA.Methods This cross sectional study was carried out between March 31August 8, 2008, in healthy term neonates at roomingin ward, Department of Obstetric & Gy necology, Cipto Mangunkusumo Hospital (CMH). All eligible subjects were examined for Bf and BERA using standard methods. Results ...
Audiological Assessment of Neonates with Hyperbilirubinemia
2013
Background: Neonatal hyperbilirubinemia is a very common problem of newborn and can lead to serious neurological squeal. Transient otoacoustic emission (TOAE) and auditory brain stem response (ABR) are most widely used devices to assess newborns peripheral auditory sensitivity and pathway integrity respectively. Objective: to assess the auditory function in neonates suffering from hyperbilirubinemia, correlate different levels of bilirubin in neonates with ABR findings and to identify the effect of treatment of hyperbilirubinemia on neonates, auditory functions. Patients and Methods: 70 full term newborns with no risk factors for hearing loss; other than having hyperbilirubinemia with different bilirubin levels; requiring phototherapy and/ or exchange transfusion, compared to 30 normal neonates who were delivered normally or by caesarian section were included in this study. All were subjected to TOAE and ABR testing. Cases were tested before and after phototherapy and / or exchange ...