Histology – History, Short Review Of Techniques And Application In Modern Science (original) (raw)
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Histological Methods in Life Science
Histology is the microscopic study of plant and animal tissues. Although all organisms are comprised of at least one cell, we will be focusing on observing cells and tissues of the human body. Histology is the study of tissue structure, extending from the level of the individual cell, through organs to organ systems. Histology is obviously related to Cell Biology and to Anatomy; it also forms the structural basis for understanding Function and is the preparation for the study of abnormal structure and function. In this methodology articles histology followed various methods clearly explain researchers and science innovators.
Different Types Of Tissues In Modern Science Of Histology
2018
Histology is a field of science focused on analysis of structure, development and function of cells and tissues of animals and plants. The study uses microscopy as its main tool of analysis. Histology includes the knowledge about microscopic structure of organs and also cytology and embryology. The science focused on histology of ill tissues and cells is called histopathology. It is a very important tool in analysis of anatomical pathology of morbid tissues, which appears in cancerous cells in animal or human body. Histology is essential for understanding and development of disciplines such as medicine, biology, veterinary medicine and many different sub-disciplines.
J Histol Histopathol Res , 2019
Histology is the science of the visualization of tissues in live beings. Using a lot of methods currently available, the histologist can understand the tissue organization, its variations under several conditions. He can also understand the structure and molecular composition of cells. These precise observations have been made possible by the development of concepts and techniques, as shown by the history of science. Although the use of the microscope was not unanimous at the beginning, histology is now commonly used for studies in life sciences and biomedicine. Thus, since the beautiful cave paintings, the human being has managed to develop means of observation, more and more powerful, leading to our most recent microscopes capable of observing structures on a molecular scale, not to say atomic.
Introduction of Histopathology
Molecular Histopathology and Cytopathology
Histopathology is the science that studies disease pathology through morphological changes that can be seen microscopically. The word histopathology was first known to be introduced in a book entitled “On the Nature and Structure Characteristic of Cancer” by Johannes Muller in 1838. Before histopathology, doctors distinguished diseases based on macroscopically visible morphology organ changes (anatomy) in the operating room or during forensic autopsies. However, this expertise requires another diagnosis method to ensure that several differential diagnoses indicate the same anatomical morphological changes. Definitive diagnosis is obtained by taking a small organ tissue sample during surgery (biopsy), which is then viewed microscopically. This diagnosis method is called histopathological diagnosis. For example, a person with hearing loss has received a differential diagnosis of conduction or sensorineural hearing loss. An external macroscopic physical examination for this patient is ...
Evolution and new frontiers of histology in bio‐medical research
Microscopy Research and Technique, 2020
Histology refers to the study of the morphology of cells within their natural tissue environment. As a bio-medical discipline, it dates back to the development of first microscopes which allowed to override the physical visual limitation of the human eye. Since the first observations, it was understood that cell shape predicts function and, therefore, shape alterations can identify and explain dysfunction and diseases. The advancements in morphological investigation techniques have allowed to extend our understanding of the shape-function relationships close to the molecular level of organization of tissues, as well as to derive reliable data not only from fixed, and hence static, biological samples but also living cells and tissues and even for extended time periods. These modern approaches, which encompass quantitative microscopy, precision microscopy, and dynamic microscopy, represent the new frontier of morphology. This article summarizes how the microscopy techniques have evolved to properly face the challenges of biomedical sciences, thus transforming histology from a merely qualitative discipline, which played an ancillary role to traditional "major" sciences such as anatomy, to a modern experimental science capable of driving knowledge progress in biology and medicine.
Once Upon a Microscopic Slide: The Story of Histology
Journal of Cytology & Histology, 2015
For centuries, histology has maintained its remarkable place in the medical curriculum. However, its teaching has been influenced by the new technological advancement that has reshaped medicine teaching into a more modern student-friendly form. Since its inception in the 18th century, the discipline of histology has progressed hand in hand with the advancements in microscopy and microscopic technologies, including immunohistochemistry. In the traditional curriculum of USA medical schools, especially after the first Flexner's report of 1910, histology was considered as very essential topic for a physician studying the "Art and Science" of medicine. In this era, the teaching relied more on the light microscope and to some extent on the electron microscope. However, the field nowadays, after the second Flexner's report, which stressed the importance of integrating clinical topics in the curriculum, is shifting towards the use of more electronic resources for teaching. Such new resources rely on information technology and electronic imaging modalities which are considered to be more student-friendly, time efficient, consistent in conveying the images, promote self-learning and are less costly. In fact, in the last 25 years, most universities started relying on virtual microscopy with limited use of the light microscopy by the students. Such an approach facilitated curricular integration of histology into histopathology and provided the opportunity to promote self-learning and clinical relevance. In the era of competency-based curriculum, histology remains an essential and indispensable basic science in the integrated modules.