Reduced water and sodium intakes associated with high levels of natriuretic factor following common bile duct ligation in the rabbit (original) (raw)

1990, British Journal of Surgery

Renal failure complicating obstructive jaundice (OJ) is probably linked to reduction of the extracellular water compartment. To elucidate the mechanism by which OJ leads to isotonic water depletion we studied a group of rabbits with OJ after common bile duct ligation (n = 17) and another group of sham operated rabbits (n = 14) for 10 days. Water intake and balance for two study periods (1–4 and 7–10 days after operation) were calculated. Renal function, sodium balance and plasma atrial natriuretic factor were determined on the fourth and tenth days after operation. Water intake and balance were lower in the OJ group both in the first study period (230 versus 519 ml/days 1–4, P<0–001; and—2·4 versus 279 ml/days 1–4, P < 0·0001 respectively) and in the second study period (260 versus 865 ml/days 7–10, P< 0·0001; and 11 versus 379 ml/days 7–10, P< 0·000 7 respectively). Sodium intake was negligible in the OJ group both on day four (0·73 versus 7·75 mM/24 h, P<0·0001) and...

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