Basal Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin Naive Patients with Type 2 Diabetes Mellitus in Primary Public Health Center (original) (raw)

Effective glycemic control is very important to minimize longterm complications of type 2 diabetes mellitus (DM). However, it is welldocumented that many patients spend prolonged periods above optimal glycaemic range, especially in primary public health centers.Most of primary care physicians, who are responsible to manage them, delay to iniate insulin therapy for some reasons. The aim ofthis study was to evaluate efficacy and safety of insulin detemir added to oral therapy in insulin-naive individuals with type 2 DM.This one group pre- and post-test study involved insulin-naive and previously oral-treated DM patients (n=64, HbA1c> 8.0%),drawn from 10 primary public health center centers all over Surabaya, Indonesia, using simple random sampling method. Patientswere treated with insulin detemir for 12 weeks and insulin doses were titrated to target fasting plasma glucose (FPG) < 125 mg/dl.Outcomes evaluated included HbA1c, level of fasting and 2 hours post-prandial glucose, ri...