A Novel Class II Phosphoinositide 3-Kinase Predominantly Expressed in the Liver and Its Enhanced Expression during Liver Regeneration (original) (raw)

The study focuses on the identification and characterization of a new class II phosphoinositide 3-kinase designated PI3K-II␥, which is predominantly expressed in the liver and undergoes increased expression during liver regeneration. This enzyme shows a specific activity towards certain phosphoinositides and is localized within liver cells predominantly in the Golgi region. Analysis of its expression through various developmental stages and post-hepatectomy reveals its potential role in maintaining hepatic function and possibly signaling pathways related to liver growth and regeneration.