Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation (original) (raw)

Targeted therapy is an effective approach for advanced cancer treatment, requiring precise identification of the target molecular pathways influenced by anticancer agents. This study performed a comprehensive transcriptomic analysis of 129 datasets involving 83 targeted drugs, confirming that compounds acting on similar pathways cluster together based on their gene expression profiles. Notably, inhibitors of oncogenic kinase pathways formed a significant and distinct group, highlighting a specific molecular pathway influenced by these agents. The analysis further elucidated unexpected target pathways and underscored the utility of transcriptomic approaches in validating and re-evaluating drug target specificity for improved treatment strategies.