Supramolecular Carotenoid Complexes of Enhanced Solubility and Stability—The Way of Bioavailability Improvement (original) (raw)
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One of the emerging and recent strategies to combat cancer is application of natural bioactive compounds and phytochemicals. Carotenoids including lycopene, b-carotene, astaxanthin, crocin, b-cryptoxanthin, and lutein, are the main group of plant pigments which play important roles in the prevention and healing process of different diseases including cancer. The pharmacological use of carotenoid compounds is frequently limited by their low bioavailability and solubility as they are mainly lipophilic compounds. The present study focuses on the current data on formulation of different carotenoid nanodelivery systems for cancer therapy and a brief overview of the obtained results. Encapsulation of carotenoids within different nanocarriers is a remarkable approach and innovative strategy for the improvement of health-promoting features and particularly, cancer prevention/treatment roles of these compounds through enhancing their solubility, cellular uptake, membrane permeation, bioaccessibility, and stability. There is various nanocarrier for loading carotenoids including polymeric/biopolymeric, lipid-based, inorganic, and hybrid nanocarriers. Almost in all relevant studies, these nano delivery systems have shown promising results in improving the efficiency of carotenoids in cancer therapy.
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Carotenoids are organic pigments naturally synthesized by microorganisms and plants. Several techniques are available for the nanoencapsulation of organic compounds: self-assembly, high pressure homogenization, nanoemulsification, supercritical fluids, etc. The objective of this paper is to review some nanoencapsulation techniques that are compatible with labile compounds, such as b-carotene. Strategies for testing the safety of nanoencapsulated b-carotene are also discussed.
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Applied Sciences, 2022
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RPS Pharmacy and Pharmacology Reports
Objectives Carotenoids are increasingly explored as nutraceuticals but their low bioavailability due to poor aqueous solubility limits their applications. This study discusses the development of a novel and organic solvent-free method to develop carotenoid-containing polymeric nanoparticles via temperature-induced phase transition (TIPT) of pluronic F-68 to obtain formulations with the improved dissolution of carotenoids. Methods The nanoencapsulation of carotenoids in pluronic F-68 was performed in supercritical carbon dioxide (scCO2) to avoid oxidative or temperature/solvent-induced degradation. The nanoencapsulates were prepared in scCO2 at 40 or 60 °C and 10 MPa without the aid of any organic solvent. The formulations thereafter were characterised for particle size via dynamic light scattering (DLS), particle morphology via Scanning Electron Microscopy (SEM) and carotenoid content/release via high-performance liquid chromatography (HPLC). Key findings HPLC results showed caroten...