Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: structural basis for altered allosteric activity (original) (raw)

Crystal structure of oxygenated Scapharca dimeric hemoglobin at 1.7-A resolution

Peter Condon

Journal of Biological Chemistry, 1994

Crystal Structure of Oxygenated Scapharca Dimeric Hemoglobin at 1.7 Angstroms Resolution

Peter Condon

1994

The Mutation K30D Disrupts the Only Salt Bridge at the Subunit Interface of the Homodimeric Hemoglobin from Scapharca inaequivalvis and Changes the Mechanism of Cooperativity

Pierpaolo Ceci

Journal of Biological Chemistry, 2002

A Single Mutation (Thr72→Ile) at the Subunit Interface is Crucial for the Functional Properties of the Homodimeric Co-operative Haemoglobin fromScapharca inaequivalvis

Francesca Polizio

Journal of Molecular Biology, 1995

Restricting the Ligand-Linked Heme Movement in Scapharca Dimeric Hemoglobin Reveals Tight Coupling between Distal and Proximal Contributions to Cooperativity †

Biochemistry, 2001

Structural and Dynamic Properties of the Homodimeric Hemoglobin from Scapharca inaequivalvis Thr-72→Ile Mutant: Molecular Dynamics Simulation, Low Temperature Visible Absorption Spectroscopy, and Resonance Raman Spectroscopy Studies

Giovanni Ciccotti

Biophysical Journal, 1998

Mutation of Residue Phe97 to Leu Disrupts the Central Allosteric Pathway in Scapharca Dimeric Hemoglobin

Journal of Biological Chemistry, 1997

Cooperative oxygen binding to Scapharca inaequivalvis hemoglobin in the crystal

stefano bettati

Journal of Biological …, 1996

The homodimeric hemoglobin from Scapharca can be locked into new cooperative structures upon reaction of Cys92, located at the subunit interface, with organomercurials

FEBS Letters, 1992

Tertiary and Quaternary Allostery in Tetrameric Hemoglobin from Scapharca inaequivalvis

Stefano Bettati

Biochemistry, 2013

Effects of mutations on the molecular dynamics of oxygen escape from the dimeric hemoglobin of Scapharca inaequivalvis

Kevin Trujillo

F1000Research, 2015

Role of subunit interfaces in the allosteric mechanism of hemoglobin

Joel Janin

Proceedings of the National Academy of Sciences, 1976

Residue F4 Plays a Key Role in Modulating Oxygen Affinity and Cooperativity in Scapharca Dimeric Hemoglobin †

Biochemistry, 2005

Structural and functional effects of selective chemical modifications of Scapharca inaequivalvis haemoglobins in relation to their unique assembly

A. Boffi

Biochemical Journal, 1987

Ligand and interfacial dynamics in a homodimeric hemoglobin

Prashant Gupta

Structural Dynamics, 2016

Stereodynamic properties of the cooperative homodimeric Scapharca inaequivalvis hemoglobin studied through optical absorption spectroscopy and ligand rebinding kinetics

Emilia Chiancone, Antonio Cupane, A. Boffi

Biophysical Journal, 1994

Functional consequences of mutations at the allosteric interface in hetero‐ and homo‐hemoglobin tetramers

O. Schaad

Protein Science, 1993

Nuclear-magnetic-resonance investigation of the cooperative homodimeric hemoglobin from the mollusc Scapharca inaequivalvis. Molecular and electronic structure of the cyano-met derivative

European Journal of Biochemistry, 1989

Ligand Uptake Modulation by Internal Water Molecules and Hydrophobic Cavities in Hemoglobins

Diego Gauto

The Journal of Physical Chemistry B, 2014

X-Ray crystallographic structural characteristics of Arabidopsis hemoglobin I and their functional implications

jagreet kaur

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013

Hydroxide Rather Than Histidine Is Coordinated to the Heme in Five-coordinate Ferric Scapharca inaequivalvis Hemoglobin

A. Boffi

Journal of Biological Chemistry, 1999

Interfacial and Distal-Heme Pocket Mutations Exhibit Additive Effects on the Structure and Function of Hemoglobin †

Virgil Simplaceanu

Biochemistry, 2008

Allosteric mechanism of haemoglobin: rupture of salt-bridges raises the oxygen affinity of the T-structure

stefano bettati

Journal of Molecular Biology, 1998

The Unique Heme–Heme Interactions of the HomodimericScapharca inaequivalvisHemoglobin as Probed in the Protein Reconstituted with Unnatural 2,4 Heme Derivatives

Archives of Biochemistry and Biophysics, 1997

Crystalline Ligand Transitions in Lamprey Hemoglobin. STRUCTURAL EVIDENCE FOR THE REGULATION OF OXYGEN AFFINITY

Journal of Biological Chemistry, 2001

The 2.0 Å Crystal Structure ofScapharcaTetrameric Hemoglobin: Cooperative Dimers within an Allosteric Tetramer

Journal of Molecular Biology, 1995

Crystallographic Evidence for a New Ensemble of Ligand-Induced Allosteric Transitions in Hemoglobin: The T-to-THigh Quaternary Transitions

Jeffrey Kavanaugh

Biochemistry, 2005

Tertiary and quaternary effects in the allosteric regulation of animal hemoglobins

Luca Ronda

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013

H-bonding networks of the distal residues and water molecules in the active site of Thermobifida fusca hemoglobin

JUAN AARON GAMARRA BUSTAMANTE

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013