The First Potent and Selective Non-Imidazole Human Histamine H 4 Receptor Antagonists (original) (raw)

Journal of Medicinal Chemistry, 2003

Abstract

Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.

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