PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia (original) (raw)

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Blood

Abstract

Key Points PHF6 is a tumor suppressor, and loss of PHF6 synergizes with ectopic TLX3 expression to cause rapid-onset fully penetrant leukemia. Loss of PHF6 leads to sustained and robust HSC reconstitution beyond quaternary transplants and promotes progenitor production.

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