A clinical study showing altered antioxidants profile in patients with hypertension (original) (raw)
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Analysis Of Level Of Antioxidants In The Prognosis Of Hypertension ., Indo Am
The main objective of the study is to find the level of antioxidants in case of hypertension patients because hypertension directly effect on blood level and heart of the patient. Methodology of the study: This cross sectional study was conducted in Tehsil Headquarter Hospital Khairpur Tamewali Bahawalpur during January 2019 to August 2019. All the data was collected according to the rules and regulations of authority. The data was collected from both genders of age between 30 to 50years. The blood was drawn from all patients for further analysis of antioxidants. Results: Our results showed that the level of antioxidants increases in hypertension patients due to increase in blood flow. The level of MDA, SOD, GSH and CAT vary in a different manner. The level of SOD become decreases due to hypertension. Antioxidants are compounds that are able to trap ROS and thus may be capable of reducing oxidative damage and possibly blood pressure. Conclusion: In conclusion, we found that hypertension increased free radical levels in the blood. According to our study, levels of free radicals increase in the blood, which may stimulate antioxidant defense systems of body during hypertension.
Association of low anti oxidant status with hypertension: cause or consequence
IOSR Journal of Pharmacy and Biological Sciences, 2012
Background and objectives: Recent studies imply an increasing association of oxidative stress in the pathogenesis of hypertension. This study was designed to evaluate oxidative stress in hypertensive subjects and to assess the correlation of antioxidant status with the severity of hypertension. Material and methods: Ninety-six hypertensive cases were divided into three groups based on severity of hypertension as per JNC VII classification. Lipid profile, antioxidant power of serum(FRAP assay) and oxidant load of serum(FOX2) of hypertensive cases were compared with an equal number of age and sex matched healthy normotensive controls. Data was analysed by Student's t test and Pearson's correlation. Result: Lipid profile, oxidant load was significantly higher in hypertensive patients in comparison to controls (P<0.001). Antioxidant status was lower in hypertensives as compared to controls. A significant correlation was observed between lipid profile vs. oxidative stress and hypertension vs. low antioxidant level (r=0.835, P<0.001) Conclusion: Above findings demonstrate a strong association between blood pressure, dyslipidaemia and oxidative parameters shows a possible role of oxidative stress in the severity of hypertension.
Different antioxidants status, total antioxidant power and free radicals in essential hypertension
Molecular and Cellular Biochemistry, 2005
Hypertension is a multi-factorial process, prevalent in developed as well as in developing countries. Different antioxidants and free radicals play an important role in cardiovascular system. In present study, total antioxidant power in terms of FRAP (ferric reducing activity of plasma), free radicals and different antioxidants have been studied in essential hypertensives (n = 50) and normal subjects (n = 50). Levels of total cholesterol, low-density lipids-cholesterol, malonialdehyde, very low-density lipids (VLDL), uric acid, plasma homocysteine and low-density lipids (LDL), were significantly higher in hypertensives as compared to normotensive. HDL-cholesterol, SOD, GPx, reduced glutahione, total glutathione, oxidized glutathione, total thiols, protein thiols, non protein thiols, RNI, total antioxidant power, vitamin A, ascorbic acid and glutahione-S-transferase (GST) were decreased significantly in normotensive. We observed significantly low nitric oxide levels in hypertensive patients. No correlation was observed between severity of disease and plasma nitric oxide levels. There was a significant decrease in plasma FRAP value in essential hypertensives as compared to normotensive controls, which showed a negative correlation with diastolic blood pressure. In conclusion, our study revealed that there was a consistent significant difference between essential hypertensives versus controls with respect to most of the parameters. These complex changes are consistent in the view that essential hypertension is associated with an abnormal level of antioxidant status compared to normal response to oxidative stress or both. (Mol Cell Biochem 277: 89-99, 2005) oped as well as developing countries with a common end result of elevated blood pressure (BP). Hypertension is present in 60 to 70% of the population over 60 years of age and may result in cardiovascular complications such as stroke, coronary heart disease (CHD), and heart failure. High blood pressure (essential hypertension) is defined as systolic pressure (SBP) greater than 140 and/or diastolic pressure (DBP)
Oxidant–antioxidant Status and Lipid Profile in the Hypertensive Patients
Journal of Nepal Health Research Council, 2009
Background: Hypertension is associated with an elevation of ROS and frequently also with an impairment of endogenous antioxidant mechanisms. Increased level of serum cholesterol, TG, VLDL has been observed in patients with hypertension. It has been shown that oxidized lipoprotein inactivates NO and aggravates hypertension. This study intends to know the association of oxidative stress and lipid profile with hypertensive patients of the Western Nepal.
American Journal of Hypertension, 2004
The objective was to study factors related to the changes induced by antihypertensive treatment on oxidative status, antioxidant activities, and reactive oxygen species by-products in whole blood and mononuclear peripheral cells. Eighty-nine hypertensive patients (mean age 46 years, 46 men, average 24-h blood pressure 139/88 mm Hg, body mass index 29) were included. After 3 months of nonrandomized allocation to antihypertensive treatment (20 nonpharmacologic, 36 -blockers, 33 angiotensin receptor blocker), oxidized/reduced glutathione ratio and malondialdehyde were significantly reduced, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly increased in both whole blood and peripheral mononuclear cells. The content of damaged base 8-oxo-2=-deoxyguanosine in nuclear and mitochondrial DNA in hypertensive subjects was also significantly reduced during the antihypertensive treatment. In a group of 42 subjects, the oxidative stress was further reduced and the antioxidant enzyme activities further increased after 12 months of antihypertensive treatment. The changes were independent of the kind of antihypertensive treatment. In conclusion, antihypertensive treatment improved the increased oxidative stress and the decreased antioxidant mechanisms. It is independent of the type of treatment and the beneficial effect of treatment increases over time.
This study was undertaken to evaluate the serum levels of Oxidant (MDA) & antioxidant (SOD & Vitamin E) and compare oxidative stress (MDA) level among normotensive and hypertensive subjects. Oxidative stress has been relationship with mechanisms of EH (essential hypertension). A total number of 70 subjects were taken including both sex (Men and Women) between the ages of 35-70 years taken in this study. Exclusion criteria were chronic diseases, alcohol consumer, obesity, smoking/tobacco consumer and current use of any medication. Antioxidant enzymes activity and lipid peroxidation (malondialdehyde) were determined in serum. In 70 subjects out of 35 were found as an controls normotensive individuals and the cases 35 hypertensive patients. Serum MDA levels were highly significantly elevated in hypertensive patients in compared to normotensive individuals (4.39±0.98 µmol/l vs 1.51±0.70µmol/l and p < 0.0001). SOD acts as an antioxidant was highly significantly decrease in hypertensive patients in compared to normotensive individuals (0.44±0.06U/mg protein/min vs 0.96±0.04 U/mg protein/min and p <0.0001). Vitamin E, which acts as a biomarker of hypertensive was significantly higher decrease in hypertensive in compared to normotensive individuals (0.69±0.08 vs 1.06±0.25 and p < 0.001). These findings demonstrate the strong association of SOD and Vitamin E level decrease in hypertensive patients and by MDA level increase in hypertensive patients. Oxidative stress in hypertensive patients increasing over time may play a role in the improvement of atherosclerosis and cardiovascular disease, should be considered in further research.
Journal of Human Hypertension, 2004
It has been suggested that increased oxidative stress may be both a cause as well as a consequence of hypertension. In vivo oxidation of low-density lipoproteins by oxygen-free radicals may increase hypertension-related atherogenesis, and antioxidants may be beneficial in this regard. Previous findings concerning associations between serum measures of antioxidants and hypertension have however been inconsistent. Plasma levels of beta-carotene, Vitamin A, E, uric acid, homocysteine and total antioxidant capacity, as well as two markers of oxidative stress, malondialdehyde (MDA) and protein carbonyls, were measured in morning fasting blood samples provided by 415 Australians aged 60-64 years, selected randomly from the community. Participants also provided information on sociodemographic attributes, mental and physical health, and provided two measures of resting blood pressure, allowing a diagnosis of definite or borderline hypertension. Those with hypertension had lower levels of beta-carotene and higher levels of uric acid and MDA compared to normotensive participants. The last two of these associations persisted when the analyses controlled for lifestyle and health factors. The findings from this study offer limited support for the proposition that lower antioxidant status and higher oxidative stress are associated with hypertension, and suggest the need for longitudinal studies to examine causality and intervention studies to determine the benefit of antioxidants in this group.
The Antioxidant Therapy: New Insights in the Treatment of Hypertension
Frontiers in physiology, 2018
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a key role in the regulation of the physiological and pathological signaling within the vasculature. In physiological conditions, a delicate balance between oxidants and antioxidants protects cells from the detrimental effects of ROS/RNS. Indeed, the imbalance between ROS/RNS production and antioxidant defense mechanisms leads to oxidative and nitrosative stress within the cell. These processes promote the vascular damage observed in chronic conditions, such as hypertension. The strong implication of ROS/RNS in the etiology of hypertension suggest that antioxidants could be effective in the treatment of this pathology. Indeed, in animal models of hypertension, the overexpression of antioxidants and the genetic modulation of oxidant systems have provided an encouraging proof of concept. Nevertheless, the translation of these strategies to human disease did not reach the expected success. This could be due to the c...
Sonu An Emerging Role of Natural Antioxidants in Hypertension
The prevalence of cardiovascular diseases (CVD) like hypertension (HT) is increasing worldwide at an alarming rate. A direct relationship occurs between blood pressure (BP) and the risk of CVD, with oxidative stress as the prime culprit. The evidence which implicates the role of oxidative stress in the pathogenesis and complications of HT suggests the beneficial role of antioxidants in the treatment and prevention of HT. Ample of studies suggest that supplementation with antioxidants play a vital role in order to delay, prevent or remove oxidative damage. Natural substances like Vitamin A, C, and E, L-arginine, Coenzyme Q and α-lipoic acid show potent antioxidant and antihypertensive effects, resulting in the suppression of elevated BP. The purpose of the present review article is to examine the mechanisms whereby natural antioxidants reduce BP in patients presented with HT.
Evaluation of antioxidant status and mineral levels in hypertensive patients in NAUTH Nnewi
Antioxidants neutralize the celldamaging effects of free radicals (Sies, 1997). Free radicals are atoms with an unpaired number of electrons that can be formed when oxygen interacts with certain molecules (Valko et al., 2004). Antioxidant compounds include vitamins A, C and E, transition metals selenium, magnesium, zinc, copper. Other antioxidants are uric acid, glutathione, albumin, bilirubin etc (Halliwell et al., 1990; Khakoni, 2004). Antioxidants abound