Estudo do recobrimento biológico de nanossuperfícies por modelagem computacional: aplicação no desenvolvimento de nanoimunossensores (original) (raw)

Análise morfológica de nanofibras Uma abordagem por visão computacional e aprendizagem de máquina

Anais do XII Computer on the Beach - COTB '21, 2021

The studies and applications of nanofibers have grown over the years. It was observed that the properties of the nanometer-scale yarns present advantages in applications in several areas, such as biomedical, energy storage and production, and applications involving water filtration. These materials are synthesized through a technical process and, for that reason, they are subject to the presentation of failures. The most common flaws are the formation of granules and pores. With the evolution of computing, applications that use machine learning resources can assist in detecting these failures. This work aims to evaluate and compare two different approaches to morphological analysis to see losses in nanofibers. Firstly, a data set was created using a Scanning Electron Microscope. After that, each image was analyzed by ImageJ software and by RNA solution. As a hypothesis, the article will assess whether the beads identification and the number of beads by the analog method are statisti...

SPR: Uma nova ferramenta para biossensores

Química Nova, 2003

Recebido em 4/1/02; aceito em 27/6/02 SPR-NEW TOOL FOR BIOSENSORS. This paper reviewed the development and theoretical aspects of surface plasmon ressonance (SPR) technique and discusses this powerful sensor technology in the development of biosensors, as well as for the investigation of biological interactions and clinical assays. The SPR has been proven to be a valuable tool to investigate dynamic processes, such as adsorption, degradation, determination of dieletric properties, association/dissociation kinetics, affinity constants of specific ligand-ligate interactions, allowing real-time analysis at almost any surface. The SPR as a complementary technique alongside electrochemical methods is also presented.

Bioatividade de nanoformulações de nim sobre a traça-do-tomateiro

Ciência Rural, 2012

O uso de plantas inseticidas é uma importante ferramenta para o manejo de insetos-praga. Visando ao controle de Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae), nanoformulações de nim foram avaliadas. Após a estimativa de uma CL50 para uma formulação de óleo comercial de nim, bioensaios de seleção foram realizados com 22 nanoformulações. Para isso, lagartas neonatas foram alimentadas sobre folíolos tratados com soluções das nanoformulações durante 10 dias. Com as duas nanoformulações mais promissoras, NC40 aquoso e NC40 pó (NC 40=nanocápsulas de Poli- β-hidroxibutirato), foi avaliado o efeito sobre o desenvolvimento e a longevidade do inseto. A CL50 para o óleo de nim foi estimada em 0,20% ou 1,31mgL-1 de azadiractina. As nanoformulações NC40 aquoso e NC40 pó afetaram o desenvolvimento do inseto.

Aplicações de QCM, EIS e SPR na investigação de superfícies e interfaces para o desenvolvimento de (bio)sensores

Química Nova, 2004

The use of the quartz crystal microbalance process, electrochemical impedance spectroscopy and surface plasmon resonance for characterizing thin films and monitoring interfaces is presented. The theorical aspects of QCM, EIS and SPR are introduced and the main application areas are outlined. Future prospects of the combined applications of QCM, EIS and SPR methods in the studies of interfacial processes at surfaces are also discussed.