Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C (original) (raw)

Investigated the relationship between thermal hyperalgesia and morphine tolerance in a rat model, focusing on the role of excitatory amino acid receptors and protein kinase C. Developed morphine tolerance and thermal hyperalgesia were assessed through specific behavioral tests, with pharmacological interventions using NMDA and non-NMDA receptor antagonists revealing crucial pathways for both phenomena. The findings suggest common neural mechanisms contributing to hyperalgesic states across various clinical conditions, emphasizing the significance of NMDA receptor activation and PKC in the development of morphine-induced hyperalgesia.