Structural and Dynamical Insight into PPARγ Antagonism: In Silico Study of the Ligand-Receptor Interactions of Non-Covalent Antagonists
Filip Fratev
International Journal of Molecular Sciences, 2015
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PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix
John Bruning
iScience, 2018
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Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988
John Bruning
Nuclear Receptor Research, 2018
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Virtual screening, molecular dynamics, density functional theory and quantitative structure activity relationship studies to design peroxisome proliferator-activated receptor-γ agonists as anti-diabetic drugs
Nadia Afrin
Journal of Biomolecular Structure and Dynamics, 2020
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Flexible ligand recognition of peroxisome proliferator-activated receptor-γ (PPARγ)
Hiroaki Tokiwa
Bioorganic & Medicinal Chemistry Letters, 2010
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Structure based Docking and Molecular dynamics studies: Peroxisome proliferator-activated receptors–α/γ dual agonists for treatment of metabolic disorders
Virendra Nath Srivastav
Journal of Biomolecular Structure and Dynamics, 2019
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Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design
giuseppe fracchiolla
Journal of Medicinal Chemistry, 2008
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Flexible ligand recognition of peroxisome proliferator-activated receptor-? (PPAR?)
Hiroaki Tokiwa
Bioorg Medicinal Chem Letter, 2010
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SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism
John Bruning
ACS Chem Biol , 2016
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Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
Giorgio Pochetti
Scientific Reports, 2016
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Discovery of a Novel Selective PPARγ Ligand with Partial Agonist Binding Properties by Integrated in Silico/in Vitro Work Flow
Brask Sonne
Journal of Chemical Information and Modeling, 2013
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Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding
Amanda Bernardes
PLoS ONE, 2012
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Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptorα Helix 12 Dynamic Behavior
W. Li
Journal of Biological Chemistry, 2007
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Ligand-Induced Stabilization and Activation of Peroxisome Proliferator-Activated Receptor γ
Ingebrigt Sylte
Chemical Biology & Drug Design, 2008
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Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities
Chiung-tong Chen
Journal of Medicinal Chemistry, 2006
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Insights into the Mechanism of Partial Agonism CRYSTAL STRUCTURES OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ LIGAND-BINDING DOMAIN IN THE COMPLEX WITH TWO ENANTIOMERIC LIGANDS
Fernando Mazza
The Journal of Biological Chemistry, 2007
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Faculty of 1000 evaluation for Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ
Dinesh Nath
F1000 - Post-publication peer review of the biomedical literature, 2018
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Identification of a PPAR Delta Agonist: An In Silico Approach Towards Drug Design for Metabolic Syndrome
Asha Abraham
Prospects in Bioscience: Addressing the Issues, 2012
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In-silico Analysis of Phenyl Propanoic Acid Derivatives to Design Potent Peroxisome Proliferator-activated Receptor (PPAR) Dual Agonists for Type 2 Diabetes mellitus Therapy
Usha Chouhan
Oriental Journal of Chemistry, 2018
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DESIGN OF NEW PEROXISOME PROLIFERATORS GAMMA ACTIVATED RECEPTOR AGONISTS (PPARγ) VIA QSAR BASED MODELING
Abdul Wadood Siddiqui
Journal of Applied Pharmaceutical Sciences and Research, 2018
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Insights into the Mechanism of Partial Agonism: CRYSTAL STRUCTURES OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR LIGAND-BINDING DOMAIN IN THE COMPLEX WITH TWO ENANTIOMERIC LIGANDS
F. Loiodice
Journal of Biological Chemistry, 2007
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Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor α/γ
Letizia Giampietro
Journal of Structural Biology, 2015
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Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptor Helix 12 Dynamic Behavior
Walter Wahli
Journal of Biological Chemistry, 2007
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Structural Determinants of the Agonist-independent Association of Human Peroxisome Proliferator-activated Receptors with Coactivators
Ferdinand Molnar
Journal of Biological Chemistry, 2005
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Exploring the Binding Site Structure of the PPARγ Ligand-Binding Domain by Computational Solvent Mapping †
Sandor Vajda
Biochemistry, 2005
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Chemometric Modelling of PPAR-α and PPAR-γ Dual Agonists for the Treatment of Type-2 Diabetes
Usha Chouhan
Current Science, 2016
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Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling
Amiram Goldblum
Scientific Reports
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A Comparative Study on Selective PPAR Modulators Through Quantitative Structure-Activity Relationship, Pharmacophore and Docking Analyses
Kunal Roy
Current computer-aided drug design, 2017
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Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
Balint Balint
Endocrine, metabolic & immune disorders drug targets, 2006
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Review of the Structural and Dynamic Mechanisms of PPARgamma Partial Agonism
John Bruning
PPAR Research, 2015
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CHARMM Force Field Parameterization of Peroxisome Proliferator-Activated Receptor γ Ligands
Paulo C . T . Souza
International journal of molecular sciences, 2016
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