Thyroid profile and iron metabolism: mutual relationship in hypothyroidism (original) (raw)
Related papers
Relationship between Iron Profile and Thyroid Profile in Hypothyroid Patients
NATIONAL JOURNAL OF LABORATORY MEDICINE
Introduction: Thyroid hormone biosynthesis is dependent on iron metabolism. Changes in iron metabolism and its deficiency may cause a change in the profile of thyroid hormone. Such interferences caused can lead to hypothyroidism in case of anaemia or the other way round. Aim: To find a relationship between various parameters of iron profile to that of thyroid profile in hypothyroid patients when compared to normal healthy subjects. Materials and Methods: Present case-control study was conducted on 50 hypothyroid patients and 50 healthy subjects of same age, in the Department of Endocrinology, IGIMS, Patna between April 2017 to June 2018. Serum ferritin and Serum T3, T4, and Thyroid Stimulating Hormone (TSH) were estimated by Chemiluminescence Immuno Assay (CLIA) method. Serum iron estimation was done using TPTZ (2,4,6-Tripyridyl-s-triazine) method and Total Iron Binding Capacity (TIBC) estimation was done by Nitroso PSAP method. All statistical test and analysis were performed in St...
Assessment of Iron, Ferritin, TIBC and LDH levels a cross sectional study in Hypothyroid patients
International Journal of Clinical Biochemistry and Research, 2021
Aim: Is to study the changes of serum ferritin, Iron, TIBC and LDH levels which may affect the thyroid functions in hypothyroid patients. Materials and Methods: Serum Thyroid profile, Ferritin levels were estimated in 50 age and sex matched controls and patients of hypothyroidism, using CLIA in Mindray. Serum Iron, TIBC and LDH levels were estimated in ERBA chem7 and the results were correlated statistically. Results: Serum ferritin levels were found to be significantly decreased in patients with hypothyroidism compared to normal subjects (p Conclusion: Hypothyroidism is associated with low serum ferritin levels. The estimation of serum ferritin may help in understanding the etiopathogenesis, diagnosis, and monitoring of hypothyroid patients. Keywords: Ferritin hypothyroidism, LDH -Lactate Dehydrogenase, TIBC -Total iron binding capacity.
İron Metabolism İn Pati̇ents with Impaired Thyroid Function
J. Fac. Pharm, 2003
We aimed in this study to determine the changes due to hyperthyroidism or hypothyroidism in serum ferritin, iron, transferrin, vitamin B n and erythrocytic parameters and to investigate the interrelationships between these parameters .Serum ferritin, iron, total iron-binding capacity (transferrin), vitamin B 12 , total andfree trüodothyronine (TT 3 and FT 3) , total andfree thyroxine (TT 4 and FT 4), thyroid-stimulating hormone (TSH) levels were measured in 30 patients (26 women, 4 men) with hyperthyroid; 30 patients (26 women, 4 men) with hyporthyroid and 25 healthy subjects (22 women, 3 men). Serum ferritin levels of hyperthyroid patients were higher than those of hypothyroid patients and healthy controls (p<0.05). Serum iron levels of hyperthyroid patients were only higher than those of hypothyroid patients (p<0.05). Transferrin levels were higher in ali of patients than healthy group (p<0.05). Vitamin B 12 concentrations in hypothyroid patients were lower than those of hyperthyroid patients. Total and free T 3 and total and free T 4 levels in hyperthyroid patients were higher than those of hypothyroid patients and controls (p<0.05), but TSH levels were lower than only those of hypothyroid patients. Statistical analysis between the groups according to erythrocyte count were insignificant. The differences between haemoglobin and hematocrit levels in group of patients were also insignificant. The effects of sex, smoking status, use of salt (with or without iodine), goitrogenic food on the serum parameters were statistically investigated. Our data suggest that alterations in thyroid status produce changes in iron metabolism and vitamin B 12 levels.
Altered Iron Metabolism in Subclinical Hypothyroidism: Myth or Reality
Subclinical hypothyroidism refers to thyroid hormone deficiency in patients who have no apparent clinical features. Both iron deficiency anemia and subclinical hypothyroidism, due to their high prevalence and close interrelation, are significant clinical problems. Aims and Objectives: Association of subclinical hypothyroidism and disordered iron metabolism was studied so that better management of iron deficiency could be advised in these patients. Materials and Methods: 150 newly diagnosed subclinical hypothyroid patients and 150 healthy euthyroid controls were included. Total T 3 , total T 4 , TSH, iron, TIBC, transferrin and ferritin were measured. Data was analysed by student't' test and Person's formula. Results: Mean total T 3 , total T 4 , iron, TIBC, transferrin and ferritin values of study group were lower than that of control group (p < 0.05). Mean TSH values of study group was higher than that of control group (p < 0.05). Total T 4 and T 3 were positively correlated with transferrin (p < 0.05). The patients of subclinical hypothyroidism had altered iron metabolism. Conclusion: Decreased iron profile in subclinical hypothyroidism was significantly high. It was suggestive to regularly investigate iron profile for early detection and its early management in case of subclinical hypothyroidism.
To study prevalence of incipient iron deficiency in primary hypothyroidism
International Journal of Research in Medical Sciences, 2014
Background: Hypothyroidism, affects around 1% of general population. Anemia in association with hypothyroidism has been studied since 1881. Iron deficiency has multiple adverse effects on thyroid metabolism. It decreases circulating thyroid hormone concentration, blunts thyrotrophic response to TRH, decreases serum T 3. Objective of current study was to find prevalence of iron deficiency in primary hypothyroid. Methods: In our study 70 patients were selected, out of which 50 were females and 20 were males, who were suffering from hypothyroidism. Iron deficiency in the study group was confirmed at baseline using multiple iron status indicators (serum ferritin, serum iron, TIBC & percentage Saturation). These patients were between age group 18-65 years. Results: In our study only 14 patients (20%) manifested with anemia (which was defined as Hb<12gm/dl), where as the prevalence of iron deficiency (with or without anemia) was 34.2%, in which 28.5% were females and 5.70% were males, thus showing that prevalence of iron deficiency (with or without anemia) can be higher than iron deficiency anemia itself, which is supported by literature. Conclusion: Iron deficiency was present in a significant portion of patients with primary hypothyroidism. It also concluded that frequency of iron deficiency (with or without anemia) was higher than iron deficiency anemia.
Association between serum ferritin and thyroid hormone profile in hypothyroidism
International Journal of Medical Science and Public Health, 2015
Background: Ferritin is an iron storage protein found in almost all of the body tissues. Serum ferritin levels also have been reported to be altered in patients with thyroid disease. Thus, changes in the serum concentrations of ferritin reflect thyroid function. Objective: For the synthesis of thyroid hormones, thyroperoxidase requires iron. It has been suggested that there is an association between thyroid profile and ferritin levels, which is the storage protein for iron in the body. This study was undertaken to assess ferritin levels in hypothyroid patients. Materials and Methods: Ferritin levels were estimated in 50 newly diagnosed patients of hypothyroidism using chemiluminescence technique (ADVIA Centaur CP). Total T3 and T4 levels were estimated using radioimmunoassay. Free T3, T4, and thyroid-stimulating hormone (TSH) levels were estimated using chemiluminescence. These were then compared with age-and sex-matched healthy controls. Results were correlated statistically. Results: Serum ferritin levels were found to be significantly reduced in patients with hypothyroidism compared to normal subjects (p < 0.001). Conclusion: Hypothyroidism is associated with low serum ferritin levels. The estimation of serum ferritin may help in understanding the etiopathogenesis, diagnosis, and monitoring of hypothyroid patients.
Scientific reports, 2018
Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free of thyroid disease, participants in a national, cross sectional, population based study representative of the Spanish adult population. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) were analyzed by electrochemiluminescence (E170, Roche Diagnostics). Serum ferritin was analyzed by immunochemiluminescence (Architect I2000, Abbott Laboratories). As ferritin levels decreased (>100, 30-100, 15-30, <15 µg/L) the adjusted mean concentrations of FT4 (p < 0.001) and FT3 (p < 0.001) descended, whereas TSH levels remained unchanged (p = 0.451). In multivariate logistic regression models adjusted for age, sex, UI, BMI and smoking status, subjects with ferritin levels <30 µg/L were more likely to present hypothyroxinemia ...
Comparative Study of Serum Ferritin in Hypothyroid and Euthyroid Subjects
International Journal of Multidisciplinary Research and Explorer (IJMRE), 2021
Background:- Thyroid harmones triiodothyronin (T3) and thyroxin (T4) are secreted by thyroid glands and secretion of thsese harmone is under feedback control of Thyroid Hormone (TSH) and ferritin by chemiluminescent immunoassay autoanalyser. Results:- In our study we found that mean value of serum ferritin concentration in hypothyroid subjects was lower (13.51±6.13 ng/ml) as compared to the mean value of serum ferritin among euthyroid subjects (41±11.41 ng/ml) and it was found to be statistically significant. We observed a negative correlation between serum TSH and serum ferritin among study subjects (r= -0.89). Conclusion:- Serum ferritin level decreases in hypothyroid patients and it further aggravates hypothyroidism, so ferritin level should be assessed in hypothyroid subjects. Stimulating Primary (TSH). Harmone hypothyroidism is a state in which thyroid harmone T4 and T3 are reduced and TSH level increased in serum. Hypothyroidism affects haematopoietic system and causes anaemia. Iron is required for thyroid peroxidase enzyme which catalyses thyroid harmone biosynthesis. Ferritin is storage form of iron and its serum level reflects iron stores of body. Altered level of serum ferritin have been reported in patients with thyroid disease. So the present study was done to observe serum ferritin level in primary hypothyroidism and to compare it with euthyroid subjects and to determine correlation between serum ferritin and thyroid harmone level. Material and Methods:- This cross sectional study was done in January 2019. On the basis of TSH values 40 hypothyroid subjects as case and 40 euthyroid subjects as matched controls were included. Informed consent was taken from all study participants. Subjects with TSH value >5.5 µIU/ml were taken as hypothyroid and TSH value <5.5 µIU/ml were taken as euthyroid. Serum was analyzed for freeT3, freeT4, Thyroid-Stimulating
Interpretation of Biochemical Tests for Iron Metabolism in Hyperthyroidism
2014
Objective: Several studies suggest that thyroid hormones may affect erythropoiesis. However the mechanism by which thyroid hormones alter the ferritin concentration is not well known. Therefore, the present case-control study was designed to determine the changes due to hyperthyroidism in serum ferritin, iron and transferrin levels and to investigate the inter-relationship between these parameters. Material: This study was conducted on 50 newly diagnosed hyperthyroid patients and the results were compared with 50 age and sex matched healthy controls. Serum ferritin was assessed by two site sandwich immunoassay using direct chemiluminometric technology. TIBC and serum iron were estimated by colorimetric method. Results: Serum ferritin (314.43 ± 68.7 ng/mL) and iron concentration (159.88 ± 36.28 µg/dL) were found to be increased in hyperthyroid patients as compared to healthy controls (255.23 ± 45.5 ng/mL and 110.52 ± 20.52 µg/dL respectively). There was a significant difference betwe...
Study of impact of subclinical hypothyroidism on iron status and hematological profile
International Journal of Advances in Medicine, 2018
Background: Thyroid hormones play an important physiological role to maintain balance of metabolism of entire human body. Erythrocyte abnormalities are frequently associated with thyroid disorder. Subclinical hypothyroidism, often a hidden entity, is associated with iron-deficiency anemia along with other hematological disorders. Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction has profound effects on blood cells such as anemia, alters RBC indices including MCV, MCHC as well as iron stores. Present study was carried out to investigate and explore subclinical hypothyroid patients, to know the effect of subclinical hypothyroidism on hematological parameters and body iron store.Methods: This retrospective study included 200 newly diagnosed, untreated subclinical hypothyroid, and 200 healthy euthyroid individuals. The hematological parameters and thyroid profile of the subjects were assessed by the mean, standard deviation (SD). S...