Electronic spectra of indolyl radicals: a time-dependent DFT study (original) (raw)

2002, Chemical Physics Letters

Reactions of Melatonin and Related Indoles with Free Radicals: A Computational Study

Journal of Medicinal Chemistry, 1998

Melatonin is being increasingly promoted as a therapeutic agent for the treatment of jet lag and insomnia and has been recently suggested to act as an efficient free-radical scavenger. In the present work, its mechanisms of action for scavenging hydroxyl radicals have been investigated using semiempirical AM1 and density functional theory (DFT) computational tools. Two different reactions were proposed as follows: one involving the abstraction of an indolic hydrogen to yield a neutral radical and another involving the addition of the hydroxyl radical to the indolic moiety. Our results show that, from a thermodynamical standpoint, melatonin may directly scavenge hydroxyl radicals both in vacuum and in aqueous solution. The structural requirements for free-radical-trapping ability have been examined comparing melatonin with related indoles. Computational data suggest that 5-methoxy and N-acetyl groups of melatonin do not significantly affect its thermodynamical capacity of free-radical trapping. The present results support experimental data on the potential of melatonin as a physiological or pharmacological antioxidant agent.

Gas-Phase Electronic Spectrum of the Tropyl C 7 H 7 Radical †

The Journal of Physical Chemistry A, 2002

One color resonance enhanced two photon ionization spectra of the tropyl C 7 H 7 and C 7 D 7 radicals were recorded in a molecular beam. Tropyl was produced in a supersonic plasma source using different precursors to identify its vibronic bands. The vibronic system is assigned to the 2 E′′ 3 r X 2 E′′ 2 electronic transition with origin near 25 719 cm -1 . It covers 6 000 cm -1 revealing a large change of geometry due to a Jahn-Teller distortion in both the ground and the excited states. Ab initio calculations were carried out on the Jahn-Teller configurations to guide the assignment.

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