The Association of Helicobacter pylori Infection with Endothelial Dysfunction in Pediatric Patients (original) (raw)
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Risk of Cardio Vascular Disease in Subjects with Helicobacter pylori Infection
2014
An attempt was made to detect the presence of IgA, IgG and IgM antibodies to H.pylori by ELISA techniques in 180 subjects (90 men and 90 women) selected at random from a coastal village of Kerala. IgM antibodies against H. pylori were not detected in any of the samples indicating that non of the patients was having any recent infection. More than 30% of the subjects were positive either to IgA or IgG antibody to H.pylori of which more than 11% were positive for both IgA and IgG antibodies. There is a slight female predominance especially in the case of IgA antibodies. H. pylori patients with CVD and without CVD from the above group and equal number of healthy age and sex matched controls were evaluated for lipid profile. High sensitive CRP were statistically higher in H.pylori subjects than the controls. The lipid profiles of H.pylori patients with and without CVD were statically different from that of the controls. It was concluded that H.pylori contribute to the pathogenesis and p...
Pediatrics International, 1995
Seventy-five children (aged 9-14 years) infected with Helicobacter pylori were studied endoscopically and morphologically for the signs of infection and immune response by ELISA technique (total IgE and specific IgG against H. pylori); a control group of 36 children (not infected with H. pylori) were studied simultaneously. Helicobacter pylori positive children examined endoscopically revealed a number of mucous membrane changes including erythema, erosions, lymphoid nodular hyperplasia and ulcers. Gastritis was confirmed by histology in 58 children; 6% were termed 'active', others were 'non-active'. When studying the concentrations of anti-H. pylori IgG in children from the control group they were considered to be seronegative but in children infected with H. pylori a considerable increase was noted. An evaluation of the interaction between anti-H. pylori IgG titers and age, endoscopic signs and histology was carried out. Suppositions were made about the presence of links between these characteristics. Children with H. pylori infection showed a considerable increase of total IgE titers in comparison with the control group, The role of IgG and IgE in the development of chronic gastroduodenal diseases associated with H. pylori is discussed.
Endothelial Dysfunction Is Reversible in Helicobacter Pylori-Positive Subjects
The American Journal of Medicine, 2011
Studies have shown an association between Helicobacter pylori (HP) infection and atherosclerosis. Although epidemiological studies have suggested an association between HP infection and atherosclerosis, the issue is still controversial. It is not clear whether HP eradication will reverse endothelial damage and prevent cardiovascular events. METHODS: Thirty-one dyspeptic subjects (16 men, 15 women; 50.8 Ϯ 16.7 years) were diagnosed as HP positive using histopathological evaluation. Eleven dyspeptic subjects (5 men, 6 women; 55.4 Ϯ 9.3 years) were negative to HP (controls). Interleukin-6 level and vascular measurements (ankle brachial index and flow-mediated diameter percent change) were done twice: on entry and 3 months afterwards. HP-positive subjects were treated with the triple therapy. RESULTS: Thirty-one HP-positive subjects (50.8 Ϯ 16.7 years, 16 men, weight 79.6 Ϯ 14.8 kg, height 1.70 Ϯ 0.1 m, body mass index [BMI] 27.5 Ϯ 4.4, waist circumference 97.6 Ϯ 16.7 cm) were treated accordingly. There were 11 HP-negative subjects (controls) (55.4 Ϯ 9.3 years, 5 men, weight 83.4 Ϯ 16.8 kg, height 1.68 Ϯ 0.1 m, BMI 29.6 Ϯ 6.1, waist circumference 104.4 Ϯ 13.7 cm). No difference in age (P ϭ .27), weight (P ϭ .51), height (P ϭ .50), BMI (P ϭ .30), or waist circumference (P ϭ .20) was observed. HP-positive subjects had severe endothelial dysfunction (Ϫ1.26 Ϯ 8.4%) that improved after treatment (8.4 Ϯ 9.0%) (P ϭ .001). HP-negative subjects had endothelial dysfunction (1.9 Ϯ 9.7%) that was not improved (5.6 Ϯ 8.3%) (P ϭ .41). Interleukin-6 levels in serum were not elevated in HP-positive subjects before or after HP eradication (8.4 Ϯ 17.5 vs 13.5 Ϯ 30.7 pg/mL; P ϭ .45). CONCLUSIONS: The novel finding of our study was that HP eradication can improve endothelial dysfunction.
How and when investigating and treating Helicobacter pylori infection in children
2018
For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Then, invasive tests i.e. gastroscopy are necessary to confirm the infection. As antibiotics are not widely available in children affected by Helicobacter pylori infection, they should be chosen based on individual antibiotic susceptibility testing obtained by gastric biopsy specimens or the local antibiotic resistance pattern, in empirical treatment is chosen. Test and treat strategy in children should be avoided. In this brief review we summarize how and in which children the infection should be investigate and which the most appro...
Helicobacter pylori Infections in Children
Antibiotics
In the context of epidemiology, host response, disease presentation, diagnosis, and treatment management, the manifestation of Helicobacter pylori (H. pylori) infection diverges between children and adults. H. pylori infection stands out as one of the most prevalent bacterial infections globally, and its prevalence in both children and adults is decreasing in many developing countries but some still struggle with a high prevalence of pediatric H. pylori infection and its consequences. The majority of infected children are asymptomatic and pediatric studies do not support the involvement of H. pylori in functional disorders such as recurrent abdominal pain. The pathophysiology of H. pylori infection relies on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. This interaction gives rise to diverse gastritis phenotypes, which subsequently influence the potential development of various gastroduodenal pathologies. In clini...
2013
This study was conducted to evaluate the biochemical and the immunological changes in Cardio Vascular Disease (CVD) patients with H. Pylori infection. Fifty H. pylori patients with CVD and fifty H.pylori patients without CVD were included in the study. For comparison of the result fifty normal, healthy age and sex matched controls were also included. The blood pressure, BMI and waist circumference of H. Pylori patients were higher than that of the controls. There was no statistically difference between the test subjects. The renal function of the test and control subjects were with in the normal limit whereas Aspartate amino transferase, blood sugar and high sensitive CRP were statistically higher in H.pylori subjects than the controls. The increase in the above parameters was higher in patients with CVD. The lipid profiles of H.pylori patients with and without CVD were statically different from that of the controls. It was concluded that H.pylori contribute to the pathogenesis and ...
Boletín médico del Hospital Infantil de México
Helicobacter pylori is usually acquired during childhood and remains in the gastric mucosa for years, often lifelong if untreated. It can be concluded that the gastric mucosa of children actively responds to the presence of H. pylori. Current evidences suggest that whereas H. pylori infection rarely causes peptic ulcers or gastric atrophy in children, it seems to be associated with iron defi ciency and iron defi ciency anemia; the evidence also suggests the infection may cause growth retardation. In contrast, H. pylori infection has been associated with a reduced risk of asthma and allergy in children and adults; also, epidemiological studies suggest that there is an inverse association between H. pylori infection and risk for esophageal adenocarcinoma. The gastric mucosa of children elicits a signifi cant infl ammatory response in the site of infection, with increased expression of toll-like receptors (TLRs) and cytokines, and increased epithelial proliferation. This response may p...
Circulation, 1998
Associations have been suggested between Helicobacter pylori seropositivity, cardiovascular risk factors, and ischemic heart disease (IHD). The effect of this common infection on mortality is uncertain. Plasma specimens collected during 1979 to 1983 from 1796 men in Caerphilly, South Wales, were analyzed for IgG antibodies to H pylori. Cause of death and occurrence of incident IHD events were ascertained over an average of 13.7 years from death certificates, hospital records, and ECG changes at 5-yearly follow-up examinations. Seventy percent of men were seropositive. The prevalence of IHD at entry was similar in men with and without H pylori antibodies (odds ratio [OR], 1.10; 95% CI, 0.87 to 1.40). Seropositivity was significantly (P<0.05) associated with poorer socioeconomic status currently and in childhood, shorter stature, and poorer ventilatory function at entry but not with age, smoking, body mass index, blood pressure, total cholesterol, HDL cholesterol, LDL cholesterol, fibrinogen, plasma viscosity, or heat shock protein antibodies. Thirteen-year incidence of IHD was not significantly associated with H pylori (OR, 1.05; 95% CI, 0.80 to 1.39), but there was a stronger relationship with all-cause mortality (OR, 1.46; 95% CI, 1.12 to 1.92) and fatal IHD (OR, 1.54; 95% CI, 1.03 to 2.30). After adjustment for cardiovascular risk factors and both adult and childhood socioeconomic status, ORs were slightly reduced and lost statistical significance (OR=1.32 [95% CI, 0.99 to 1.78] for all-cause mortality and OR=1.52 [95% CI, 0.99 to 2.34] for fatal IHD). H pylori infection is unlikely to be as strong a risk factor for IHD as some previous studies have suggested, but its relationship to mortality, including fatal IHD, deserves further investigation. The mechanism underlying these associations is unlikely to involve hypertension, circulating lipid profile, fibrinogen, or cross-reacting antibodies to bacterial heat shock proteins.
2009
The Helicobacter pylori infection is one of the mos t widespread infections in the world, with the grea test incidence in developing and undeveloped countries ( 10%). It is approved today that Helicobacter pylori causes gastritis and peptic ulcer disease, and that the lo ng-term infection is associated with a high risk fo r developing a gastric adenocarcinoma or malignant lymphoma. This infection is included by WHO in the 1st carcinogene tic group. The gold-standard in diagnosing the Helicoba cter pylori infection is the gastric biopsy; the evaluation of treatmentsefficacy involves urea breath test as w ell as the detection of stool antigens. The bases o f the genetic predisposition depend on the genic susceptibility o r on the DNA repairing mechanisms and carcinogenesi s. The treatment response of the Helicobacter pylori infe ction has genic determinism. The polymorphism of th e host, implying the genes CYP2C19 and MDR1, influences the pharmacokinetic and clinic efficacy of the tre...