Experimental models of human bladder carcinogenesis (original) (raw)
AI-generated Abstract
Bladder cancer is a significant health concern, yet there is limited understanding of its carcinogenic mechanisms. Current research has developed both in vitro and in vivo experimental models to explore human bladder carcinogenesis, particularly emphasizing the use of normal human urothelial cells (NHU). Advancements in cell culture techniques facilitate the investigation of tissue-specific responses to carcinogens and contribute to identifying key genes involved in bladder cancer progression. This review highlights genetic alterations associated with urothelial cell carcinoma (UCC), delineating distinct pathways of tumor development and the challenges in predicting tumor behavior in clinical settings.
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.