Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas (original) (raw)
Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases
Ömer Nuri Pamuk
Arthritis Research & Therapy, 2010
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An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis
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… England Journal of …, 2010
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Inhibitors of switch kinase ‘spleen tyrosine kinase’ in inflammation and immune-mediated disorders: A review
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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy
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Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk
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Kinetic assay for characterization of spleen tyrosine kinase activity and inhibition with recombinant kinase and crude cell lysates
Augustin Amour
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A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism
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Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus‐prone mice
Rena Bahjat
Arthritis & Rheumatism, 2010
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Specific Inhibition of Spleen Tyrosine Kinase Suppresses Leukocyte Immune Function and Inflammation in Animal Models of Rheumatoid Arthritis
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The Oral Spleen Tyrosine Kinase Inhibitor Fostamatinib Attenuates Inflammation and Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice
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Treatment of rheumatoid arthritis with a syk kinase inhibitor: A twelve-week, randomized, placebo-controlled trial
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A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models
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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
alex skone
Bioorganic & Medicinal Chemistry Letters, 2011
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Characterization of the Mechanism of Action of Lanraplenib, a Novel Spleen Tyrosine Kinase Inhibitor, in Models of Lupus Nephritis
David Newstrom
2020
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Development of a Pharmacodynamic Assay Based on PLC 2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)-Bruton's Tyrosine Kinase (BTK) Signaling
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Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN
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Journal of the American Society of Nephrology, 2014
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Basic Science for the Clinician 48: Tyrosine Kinases in Disease
Leonard Sigal
Jcr-journal of Clinical Rheumatology, 2008
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An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
Julie Dicarlo, Charles Peterfy
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Distinct pathways regulate Syk activation downstream of ITAM and hemITAM receptors in platelets
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PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model
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The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity
michael welsh
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Tyrosine Phosphorylation on Spleen Tyrosine Kinase (Syk) Is Differentially Regulated in Human and Murine Platelets by Protein Kinase C Isoforms
Alexander Tsygankov
Journal of Biological Chemistry, 2013
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Critical role for Syk in responses to vascular injury
Sahil A Parikh
Blood, 2011
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