In vitro pediculicidal and ovicidal activity of an extract and oil from fruits of Melia azedarach L (original) (raw)
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International Journal of Pharmaceutical and Phytopharmacological Research, 2024
The present study was to evaluate the antifertility potential of Melia azedarach leaf extract (methanol) on female Wistar rats. The antifertility activity of the methanolic extract of the leaf was evaluated by two methods namely an anti-implantation activity study and an oestrous cycle study in female rats. Female rats were given methanolic extract for anti-implantation activity from the first to the seventh day of pregnancy. On the tenth day, laprotomization was done to determine how many numbers of implants, the number of resorption sites, and the number of corpora lutea. The extract was given for 15 days in the estrous cycle trial to cover three typical estrous cycles. Every morning, a vaginal smear off each animal was examined, and the length of the each phase of the cycle was recorded. At doses of 100 mg and 200 mg/kg, respectively, the methanolic extract demonstrated substantial antiimplantation action of 56.25% and 67.86%. In comparison to the control group, the methanolic extract significantly increased the duration of the dioestrous stage and significantly decreased the duration of the meta oestrous phase. Due to the presence of phytoestrogens such as Preg-4-en-3-one, 17. alpha.-hydroxy-17. beta.-cyano, the methanolic extract of Melia azedarach leaf shows antifertility activity.
Pharmacological potentials of Melia azedarach L. - A review Email address
Medicinal plants are widely used by the traditional medicinal practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. (Ghoda Neem locally) belongs to the family Meliaceae, is a highly significant medicinal plant found almost everywhere in Bangladesh. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and so on. Experimental and clinical studies prove that it has antioxidant, antimicrobial, antiinflammatory, cardioprotective, analgesic, anticancer, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The present compendium review will focus on is traditional uses and pharmaceutical activities found on different scientific research and reports. This review also includes reports on phytochemistry, taxonomy, morphology, monographs, distribution and toxic effects of M. azedarach.