The use of muscle near-infrared spectroscopy in sport, health and medical sciences: recent developments (original) (raw)
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The use of muscle near-infrared spectroscopy in sport
2011
Near-infrared spectroscopy (NIRS) has been shown to be one of the tools that can measure oxygenation in muscle and other tissues in vivo. This review paper highlights the progress, specifically in this decade, that has been made for evaluating skeletal muscle oxygenation and oxidative energy metabolism in sport, health and clinical sciences. Development of NIRS technologies has focused on improving quantification of the signal using multiple wavelengths to solve for absorption and scattering coefficients, multiple pathlengths to correct for the influence of superficial skin and fat, and time-resolved and phase-modulated light sources to determine optical pathlengths. In addition, advances in optical imaging with multiple source and detector pairs as well as portability using small wireless detectors have expanded the usefulness of the devices. NIRS measurements have provided information on oxidative metabolism in various athletes during localized exercise and whole-body exercise, as well as training-induced adaptations. Furthermore, NIRS technology has been used in the study of a number of chronic health conditions. Future developments of NIRS technology will include enhancing signal quantification. In addition, advances in NIRS imaging and portability promise to transform how measurements of oxygen utilization are obtained in the future.
Journal of applied physiology (Bethesda, Md. : 1985), 2015
Near-infrared assessment of skeletal muscle is restricted to superficial tissues due to power limitations of spectroscopic systems. We reasoned that understanding of muscle deoxygenation may be improved by simultaneously interrogating deeper tissues. To achieve this we modified a high-power (~8 mW) time-resolved near-infrared spectroscopy system (TRS-NIRS), to increase depth penetration. Precision was first validated using a homogenous optical phantom over a range of interoptode spacing (OS). Coefficients of variation from 10 measurements were minimal (0.5-1.9 %) for absorption (μa), reduced scattering, simulated total hemoglobin, and simulated O2 saturation. Secondly, a dual-layer phantom was constructed to assess depth-sensitivity, and the thickness of the superficial layer was varied. With a superficial layer thickness of 1, 2, 3, and 4 cm (μa=0.149 cm(-1)), the proportional contribution of the deep layer (μa=0.250 cm(-1)) to total μa was 80.1, 26.9, 3.7, 0.0 %, respectively (at ...
Near-infrared spectroscopy for monitoring muscle oxygenation
Acta Physiologica Scandinavica, 2000
Near-infrared spectroscopy (NIRS) is a non-invasive method for monitoring oxygen availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi-quantitative measurements of haemoglobin plus myoglobin oxygenation (tissue O 2 stores) and the haemoglobin volume. Specialized algorithms allow assessment of the oxidation±reduction (redox) state of the copper moiety (CuA) of mitochondrial cytochrome c oxidase and, with the use of speci®c tracers, accurate assessment of regional blood¯ow. NIRS has demonstrated utility for monitoring changes in muscle oxygenation and blood¯ow during submaximal and maximal exercise and under pathophysiological conditions including cardiovascular disease and sepsis. During work, the extent to which skeletal muscles deoxygenate varies according to the type of muscle, type of exercise and blood¯ow response. In some instances, a strong concordance is demonstrated between the fall in O 2 stores with incremental work and a decrease in CuA oxidation state. Under some pathological conditions, however, the changes in O 2 stores and redox state may diverge substantially.
The Journal of Physiological Sciences, 2019
Near-infrared spectroscopy (NIRS) has become an increasingly valuable tool to monitor tissue oxygenation (T oxy) in vivo. Observations of changes in the absorption of light with T oxy have been recognized as early as 1876, leading to a milestone NIRS paper by Jöbsis in 1977. Changes in the absorption and scatting of light in the 700-850-nm range has been successfully used to evaluate T oxy. The most practical devices use continuous-wave light providing relative values of T oxy. Phase-modulated or pulsed light can monitor both absorption and scattering providing more accurate signals. NIRS provides excellent time resolution (~ 10 Hz), and multiple source-detector pairs can be used to provide low-resolution imaging. NIRS has been applied to a wide range of populations. Continued development of NIRS devices in terms of lower cost, better detection of both absorption and scattering, and smaller size will lead to a promising future for NIRS studies.
International Journal of Industrial Ergonomics, 2010
Near infrared spectroscopy (NIRS) is a simple, noninvasive method for estimating tissue oxygenation and microcirculation function. NIRS has been utilized in patients with chronic heart failure, peripheral vascular disease, chronic obstructive pulmonary disease, renal failure and other diseases. This brief review highlights the progress of the application of NIRS to evaluate skeletal muscle oxygenation during exercise in these populations.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011
This article provides a snapshot of muscle near-infrared spectroscopy (NIRS) at the end of 2010 summarizing the recent literature, offering the present status and perspectives of the NIRS instrumentation and methods, describing the main NIRS studies on skeletal muscle physiology, posing open questions and outlining future directions. So far, different NIRS techniques (e.g. continuous-wave (CW) and spatially, time- and frequency-resolved spectroscopy) have been used for measuring muscle oxygenation during exercise. In the last four years, approximately 160 muscle NIRS articles have been published on different physiological aspects (primarily muscle oxygenation and haemodynamics) of several upper- and lower-limb muscle groups investigated by using mainly two-channel CW and spatially resolved spectroscopy commercial instruments. Unfortunately, in only 15 of these studies were the advantages of using multi-channel instruments exploited. There are still several open questions in the appl...
Artery research, 2016
Continuous wave near infrared spectroscopy (CW NIRS) provides non-invasive technology to measure relative changes in oxy- and deoxy-haemoglobin in a dynamic environment. This allows determination of local skeletal muscle O2 saturation, muscle oxygen consumption ([Formula: see text]) and blood flow. This article provides a brief overview of the use of CW NIRS to measure exercise-limiting factors in skeletal muscle. NIRS parameters that measure O2 delivery and capacity to utilise O2 in the muscle have been developed based on response to physiological interventions and exercise. NIRS has good reproducibility and agreement with gold standard techniques and can be used in clinical populations where muscle oxidative capacity or oxygen delivery (or both) are impaired. CW NIRS has limitations including: the unknown contribution of myoglobin to the overall signals, the impact of adipose tissue thickness, skin perfusion during exercise, and variations in skin pigmentation. These, in the main,...
Measurement of oxidative metabolism of the working human muscles by near-infrared spectroscopy
2006
Monitoring the oxygenation of skeletal muscle tissues during rest to work transient provides valuable information about the performance of a particular tissue in adapting to aerobic glycolysis. In this paper we analyze the temporal relation of O2 consumption with deoxy-hemoglobin (Hb) signals measured by functional Near Infrared Spectroscopy (fNIRS) technique during moderate isotonic forearm finger joint flexion exercise under ischemic conditions and model it with a mono exponential equation with delay. The time constants of fitting equation are questioned under two different work loads and among subjects differing in gender. Ten (6 men and 4 women) subjects performed isotonic forearm finger joint flexion exercise with two different loads. It is shown that under the same load, men and women subjects generate similar time constants and time delays. However, apparent change in time constants and time delays were observed when exercise was performed under different loads. When t-test is applied to compare the outputs for time constants between 0.41202 Watts and 0.90252 Watts, P value of 9.3445x10-4 < 0.05 is observed which implies that the differences between the time constants are statistically significant. When the same procedure is applied for the time delay comparison, P value of 0.027<0.05 is observed which implies that also the differences between the time delays are statistically significant.
Spectroscopy, 2009
The majority ofin vivoapplications of near-infrared spectroscopic (NIRS) monitoring use continuous wave instruments that require a fiberoptic cable connection between the subject and the instrument during monitoring. In studies of muscle physiology where subjects are exercising, and particularly in those who are engaged in sports activity, a wireless instrument with telemetric capacity provides obvious advantages. Having access to reliable telemetric NIRS technology will also increase the practicality and scope of this biomedical monitoring technique in clinical settings.We report the feasibility of using a wireless continuous wave NIRS instrument with light emitting diodes, spatially resolved configuration, and Bluetooth®capability to study skeletal muscle oxygenation and hemodynamics during isometric contraction and ischemia induction.In ten healthy subjects comparable patterns of change in chromophore concentration (oxygenated and deoxygenated hemoglobin), total hemoglobin and mu...