Patient reported adverse events among epileptic patients taking antiepileptic drugs (original) (raw)
Related papers
International Journal of Basic & Clinical Pharmacology, 2018
Background: Epilepsy is a common disorder of brain function which affects around 1% of world population. Due to nature of chronicity of this disease, long term medical treatment with Anti-Epileptic Drugs (AEDs) is required to achieve control of the seizures. Antiepileptic drugs are responsible for 5% of ADRs among all of the prescribed drugs. Due to the significant number of adverse drug reactions spontaneous reporting and knowledge about ADRs have gained the importance. Knowledge(K), attitude (A) and practices (P) studies are preferred nowadays so as to have the better understanding and implication of the studies for the benefit of the patients. Therefore, this study was planned to evaluate Knowledge, Attitude and Practices (KAP) regarding Anti-Epileptic Drug (AEDs) therapy in epileptic patients and their relatives and to create awareness regarding the same.Methods: A questionnaire based study for assessment of KAP during a period of 2 months in patients of epilepsy and their relat...
Rationale use of antiepileptic drugs in patients with epilepsy at a tertiary care hospital
IP innovative publication pvt. ltd, 2019
Epileptic convulsions have negative consequences on patient’s psychological and social life like relationship, education and employment. Seizure which are uncontrolled, are always associated with poor quality of life, physical and psychosocial morbidity, increased risk of sudden unexpected death. Hence, it is important and becomes mandatory to treat epilepsy with appropriate antiepileptic drugs (AEDs) as soon as the patient reports with more than one documented or witnessed seizure. Our purpose was to investigate the use of antiepileptic drugs in epilepsy, changes in prescription patterns, exposure to specific drugs, combination of drugs, and to quantify the use of antiepileptic drugs (AEDs) in epilepsy at a tertiary care hospital. A Total of 105 patients were recruited, majority were male and between 18-25 yrs. and belonged to upper lower class. 80% were diagnosed with GTCS. Majority were on monotheraphy and phenytoin was most commonly used antiepileptic drug for the treatment of epilepsy. The drugs prescribed are mainly from older AEDs. Selection of AEDs is based on their known efficacy for specific seizure. Such studies was help in modifying the prescription guidelines as they have an important role in making rationale prescription and to see if it’s being followed at tertiary care centres. Keywords: Epilepsy, Antiepileptic drugs, Rational drug use, Drug utilization.
Factors related to the adverse events of antiepileptic drugs
Epilepsy & Behavior, 2020
The aim of the present study was to explore the factors related to the severity of the adverse effects of antiepileptic drugs (AEDs), experienced by patients with epilepsy. Materials and methods: A case study was conducted in adult patients with epilepsy and followed up at the Epilepsy Outpatients of the University Hospital of Ioannina in Northwest Greece. The Adverse Event Profile (AEP) questionnaire for AEDs adverse effects assessment, the Defense style questionnaire (DSQ-88) and the Patient Health Questionnaire (PHQ-9) for depression' severity evaluation were used to estimate the severity of adverse effects, the defense style, and the depressive symptoms, respectively. Results: Sixty-three patients with epilepsy (M/F:28/35), with a mean age of 37.6 ± 13.41, were recruited in the study. The univariate analysis showed that both the Maladaptive style of defense and the PHQ-9 score were significantly associated with the AEP score. After multivariate regression analysis female gender, the load of AEDs, the PHQ-9 score, and the Adaptive defense style remained significant coefficients. Conclusion: There are also nonpharmacological factors that may contribute to the severity of the adverse effects of AEDs, experienced by the patients with epilepsy.
A drug utilization study of antiepileptic drugs uses in a tertiary care teaching hospital of India
International Journal of Basic & Clinical Pharmacology, 2021
Background: Epilepsy is a disorder characterized by repeated seizures due to the disorder of the neurons. Epilepsy needs life-long medical therapy. It is managed by polytherapy. Drug utilization studies help to determine rational combinations of drug use in epilepsy. Aims and objectives of the study were to analyses the drug utilization pattern of anti-epileptics and common types of epileptic seizures and to determine the safety of antiepileptic drugs (AEDs).Methods: It was a prospective, cross-sectional, observational study. Patients attending neurology epilepsy OPD with h/o seizures and taking at least one antiepileptic were recruited. Data was collected by taking demographic details including brief history of disease, clinical examination and reviewing OPD prescription. Details were recorded in case record form.Results: We recruited 102 participants (57 male and 45 females) of mean age 29.68±10.52. Mean age of onset of epilepsy was 18.9±10.5 years. Among them 77 (75.4%) were diag...
International Journal of Current Pharmaceutical Research
Objective: Epilepsy or seizure disorder is a common neurologic disorder in the pediatric age group and occurs with a frequency of 4-6 cases per thousand children. Epilepsy, particularly childhood epilepsy, remains a challenge to treat. The management of epilepsy is primarily based on theuse of anti-epileptic drugs. Surgery and diet therapy are the other modes of treating childhood seizures. To get an insight into the utilization pattern of anti-epileptic drugs (AEDs) used in pediatric seizures.Methods: This prospective, longitudinal study was conducted for a period of 8months in Paediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed.Results: The distribution of paediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 y (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic s...
Prescribing pattern of antiepileptic drugs in tertiary care teaching hospital, Nagapattinam
Indian Journal of Pharmacy and Pharmacology, 2023
Background: Epilepsy is a chronic neurological disorder of brain cells. The older and newer antiepileptics are the mainstay of the treatment of epilepsy. The present study is to determine the prescription pattern of antiepileptic drugs. Materials and Methods: An observational retrospective study, conducted at government district headquarters medical college, Nagapattinam. Data was collected for about 6 months from April 2021-September 2021.100 patients were included in this study based on inclusion and exclusion criteria. Result: In 100 patients 68% accounted male and 32% accounted female. The most common type of seizure has been identified as generalized seizure (54%) followed by secondary seizure (23%) and other types. Phenytoin accounted for 69 %. Among the different classifications of antiepileptic drugs benzodiazepines (50.6%) was the commonly prescribed classification of AED. Older agents accounted almost 98% and only 2% of drugs from newer agents. TheMonotherapy has been noted only 19%. Conclusion: In this study we identified, combinational therapy has been mostly prescribed. Benzodiazepines were commonly prescribed class of agent. Phenytoin was mostly prescribed drug. Most patients have received older anti-epileptics agents. Keywords: Epilepsy, Antiepileptic drugs (AED'S), Monotherapy, Combinational therapy, Prescribing pattern
International Research Journal of Medicine and Medical Sciences
Antiepileptic drugs (AEDs) are primary therapeutic mode for epilepsy. Nevertheless, the risks of significant adverse effects and drug interaction increase when more than one drug is used. A retrospective crosssectional facility based study was carried out in Jimma university specialized teaching hospital, southwest Ethiopia, from June 25 to July 5, 2015. The sample size was determined by Joint Commission on the Accreditation of Health Care Organization (JCAHO) criteria by taking 5% of the total patient medical cards through systematic random sampling technique. Data were collected by trained data collectors using the pre-developed data collection format. It was entered onto computer and analyzed by SPSS 20.0 for window and the result was presented in tables and descriptive narrations. A total of 154 patients' treatment cards which contains AEDs were studied. 95 (61.7%) of the subjects were males and majority, 74 (48%), were in the age group of 5 to 18 years old. Generalized tonic-clonic seizure (76.3%) was the most common type of epileptic seizure seen. Monotherapy (89.7%) was most frequently used. Headache (64.4%) was the commonest adverse effect complained by the patients. Almost eighty percent (79.20%) of AED use was in accordance with indications while 20.8% were difficult to conclude whether it is correct or incorrect indications since the type of epilepsy is not specified. There was 17.7% under dose, 8.4% over dose and 21.1% AED use. There were potential drug-drug interactions in 9.4%. The present study has revealed prudent use of AEDs pertaining to indications and contraindications. The classification of seizure, use of drugs with potential drug interaction, dose and duration experiences need urgent intervention of giving health education to patients to report to physicians on follow-up days.
Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile
Neurology Research International
Introduction. Adverse events (AEs) associated with antiepileptic drugs (AEDs) affect people with epilepsy’s (PWE) quality of life. A study conducted in 15 European countries showed that the AEs prevalence of AEDs in PWE was up to 80%. To date, there are no validated screening instruments to detect AEs of AEDs in Indonesian PWE. Therefore its epidemiology is currently unknown. This study aimed to validate the Indonesian version of Liverpool Adverse Events Profile (LAEP), consequently increasing physicians’ awareness toward the probability of AEs and its necessary evaluation. Furthermore, this study was intended to determine the AEs prevalence of AEDs in Indonesian PWE. Methods. The questionnaire was translated from English into Indonesian version. The validity and reliability were tested using Spearman correlation and Cronbach’s alpha measurement. An observational cross-sectional study was carried out on consecutive PWE in outpatient clinic, Cipto Mangunkusumo Hospital. We analyzed d...
2018
Introduction: Although epileptic seizures can be controlled with monotherapy in most cases, polytherapy is used for refractory cases. A number of studies have reported the prescription patterns of antiepileptic drugs in different parts of India. Such reports are lacking in Manipur. Therefore, the present study was planned to know prescribing patterns of antiepileptic drugs in epilepsy patients in Manipur. Material and Methods: A retrospective cross-sectional analysis of prescriptions of epilepsy patients attending Therapeutic Drug Monitoring (TDM) unit in the Regional Institute of Medical Sciences, Imphal, Manipur was planned. Prescriptions of 65 epilepsy patients attending TDM unit during November, 2013 to January, 2017 were analysed with respect to demographic profiles, seizures types and number of drugs prescribed. Results were expressed in percentages. Results: Out of 65 patients, 64.61% were males. Undetermined seizures were 35.38% followed by generalised tonic clonic seizure (26.15%), complex partial seizures (21.54%), secondarily generalised (12.31%) and simple partial seizures (4.61%) respectively. Two drugs combinations were found in 38.46% followed by 1 drug treatments (35.38%), 3 drugs (16.92%) and 4 drugs combinations (9.23%) respectively. Most commonly prescribed drugs were Oxcarbazepine in monotherapy (47.83%), Oxcarbazepine with Clobazam in 2 drugs combinations (36%), Oxcarbazepine, Clobazam with Levetiracetam in 3 drugs combinations and Oxcarbazepine, Phenobarbitone, Levetiracetam and Divalproex in 4 drugs combinations (33.33%). Conclusion: Newer antiepileptic drugs were more frequently prescribed. Oxcarbazepine topped the list of prescriptions followed by Clobazam and Levetiracetam. Two drugs combination treatment was the commonest approach followed by monotherapy.
Background: In recent years many AEDs are been prescribed for indications other than epilepsy. DUE determines the quality, standards of prescribing therapy in accordance with the guidelines and to assess its prescribing trends in various epileptic and non-epileptic populations. Pharmaco-resistant epilepsy has become major medical trouble with 5 fold higher mortality rate and awaits satisfactory management. Our study will be considered as an update that builds on & expands the findings of previous studies. Materials & Methods: Evaluation of 200 prescriptions of epileptic & non-epileptic patients with an emphasis on Drug refractory epilepsy presenting to the Department of Neurology, Osmania General Hospital, Hyderabad. Aims & Objectives: To assess the AED utilization pattern in epileptic & non-epileptic conditions. Results: The probability of patients receiving Anti-epileptic Drug therapy for epilepsy was higher (55.5%) than non-epileptic patients (45%). In epileptic patients, slight female preponderance was observed over males. The dominant age group of the study was 20-40 years and the highest numbers of AEDs were prescribed for GTCS (45.94%). Polytherapy was most commonly employed. A progressive decrease in Carbamazepine use and a gradual rise of levetiracetam use was observed. 3 rd generation AEDs top the list in non-epileptic conditions. Statistical analysis comparing Monotherapy with combination therapy of gabapentin & pregabalin, we found significant p-value in different non-epileptic conditions. In our study, we found a total of 8 patients (7.20%) with drug-refractory epilepsy, of which 75% had GTCS. Conclusion: Our study highlights the relevant differences in the utilization of older and newer generation AED. Phenytoin, the conventional AED was common in epileptic patients, while 3 rd generation narrow-spectrum AEDS like gabapentin & pregabalin for non-epileptic conditions, most commonly in neuropathic pain.