in a Chinese population . cardiovascular risk factors uric acid and some Association between serum and (original) (raw)
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Songklanakarin Journal of Science and Technology, 2006
Uric acid is the final metabolite of purine. Increased serum uric acid level is associated with incidence of gout and cardiovascular diseases. The aim of this study was to investigate the relationship between serum uric acid and parameters of biochemistry and haematology in Hangzhou populations, China. In this crosssectional study, 186 male (56±14 y) and 85 female (55±11 y) free-living subjects were recruited from Hangzhou, China. The physiological parameters were measured. Each subject gave fasting blood, urine and faeces samples, from which serum uric acid and other parameters of biochemistry and haematology were measured with standard methods. Serum uric concentration was significantly higher in males than in females, 329±69 µ µ µ µ µmol/L for male and 237±53 µ µ µ µ µmol/L for female (P<0.0001). Compared with female subjects, male had significantly higher BMI (P = 0.0215), serum TAG (P = 0.0012) and creatinine (P<0.0001), significantly lower TC (P = 0.0013) and HDL-C (P<0.0001). Bivariate analysis results showed that serum uric acid was significantly positively correlated with age (r = 0.171, P = 0.0076), BMI (r = 0.343, P<0.0001), systolic blood pressure (r =
Association between serum uric acid and some cardiovascular risk factors in a Chinese population
Postgraduate Medical Journal, 1994
The association between serum uric acid concentration and some cardiovascular risk factors was examined in a working Hong Kong Chinese population (mean age 38 years), consisting of 910 men and 603 women. There was no significant age-related rise in serum uric acid concentration. Positive associations were found between serum uric acid concentration and body mass index, waist hip ratio, systolic
Serum uric acid levels and its association with cardiovascular risk factors
Iranian Journal of …, 2009
Background: Although the issue of hyperuricemia as a risk factor for cardiovascular diseases (CVD) has been disputed, several studies have shown an association between hyperuricemia and several CVD risk factors. The aim of this study was to assess distribution of uric acid level in Yazd City, center of Iran, and its association with CVD risk factors. Methods: From autumn 2004 to summer 2005, 2000 urban population of Yazd City, aging 20-74 years via clustering random sampling were enrolled in this cross sectional study. Results: Serum uric acid level, systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist/hip ratio were significantly higher in men than in women (P< 0.001),moreover, total cholesterol, HDL cholesterol and body mass index (BMI) were significantly higher in women (P< 0.001). The prevalence of hyperuricemia and metabolic syndrome in men and women was (17.9%, 11.25% P= 0.001) and (11.87%, 19.32% P= 0.01), respectively. Hyperuricemia was more prevalent in metabolic syndrome and ischemic heart disease independent of age and sex. Conclusion: Significant correlations were found between serum uric acid and several components of the metabolic syndrome. Weight, waist circumstance, triglyceride level and DBP, were the major determinants of the variations in serum uric acid levels .This could be attributed to the insulin resistance status .
Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality
Rheumatology (Oxford, England), 2013
To assess the associations between serum uric acid (SUA) level and mortality. The study included 354 110 subjects without a history of gout and whose SUA levels were tested at Chang Gung Memorial Hospital in Taiwan. Cox regression models were used to estimate hazard ratios and 95% CIs for mortality in six predefined SUA strata (≤0.17, 0.18-0.29, 0.30-0.41, 0.42-0.53, 0.54-0.65 and ≥0.66 mmol/l), after adjusting for age, sex, SUA stratum, estimated glomerular filtration rate, fasting glucose, total cholesterol and history of hypertension, diabetes mellitus, coronary heart disease, stroke, heart failure or chronic kidney disease. There were 33 562 all-cause deaths during the study period. Crude all-cause mortality rates across the SUA strata were 52.5, 19.7, 17.4, 20.0, 28.0 and 41.1 deaths per 1000 person-years. Using the stratum 3 of SUA as a reference, the age- and sex-adjusted hazard ratios (95% CIs) across SUA strata were 2.79 (2.62, 2.96), 1.32 (1.28, 1.36), 1.00, 1.10 (1.07, 1....
Association between serum uric acid levels and cardiovascular risk factors among adults in India
Nutrition, Metabolism and Cardiovascular Diseases
Background The importance of uric acid has been increasingly appreciated because of its association with the development of diabetes mellitus and related diseases. Objective This study was undertaken to evaluate the association of serum uric acid (SUA) level with different clinical and biochemical parameters in patients with type 2 diabetes from Saudi Arabia. Methods Clinical and biochemical data from the patients were obtained and assessed in a cross-sectional design. Relationships between SUA level and various clinical and biochemical parameters were analyzed. Results SUA level was positively associated with increased incidence of cardiovascular diseases (CVD) in patients with abnormal eGFR (<90 ml/min/1.73 m 2). HbA1c was found to be inversely associated with hyperuricemia in patients with normal eGFR level (90 ml/min/1.73 m 2). Incidence of metabolic syndrome did not show any relationship with SUA level. However, the incidence of hypertension, a component of metabolic syndrome, was significantly higher among patients with hyperuricemia. Waist circumference and serum triglycerides were increased, whereas serum high-density lipoprotein level was decreased in patients with higher SUA level. Patients with hyperuricemia had higher incidence of CVDs than those of the normouricemic group. Conclusion SUA level was positively associated with incidence of cardiovascular diseases CVD in patients with abnormal eGFR. HbA1c correlated significantly with SUA level in patients with normal eGFR.
Association between Uric Acid and Cardiovascular Risk Variables in a Non-Hospitalized Population
2010
Background: The association between uric acid (UA) and cardiovascular risk variables remains a controversial issue in epidemiological studies. Objective: To evaluate the association between UA, blood pressure (BP), anthropometric indices and metabolic variables in a non-hospitalized population stratified by UA quintiles. Methods: A cross-sectional observational study evaluated 756 individuals (369 males), mean aged 50.3 ± 16.12 years,
Objective: The aim of this study is to find out an association between the levels or concentration of serum uric acid in the patients present with the suspicion of suffering from CAD (Coronary Artery Disease). Methodology: Study group consisted six hundred and eighty-seven patients with suspicion of coronary artery diseases. All these patients underwent coronary angiography. Stenosis of equal or greater than 50.0% luminal diameter defined coronary artery disease. The expression of the severity of the coronary artery disease was performed as 1-vessel, 2-vessel, or 3-vessel disease. We used the standard of NCEP-ATP 3 (National Cholesterol Education Program-Adult Treatment Panel-3) for MS (Metabolic Syndrome). We obtained the aorto-femoral PWV (Pulse-Wave Velocity) invasively by arterial catheterization. Results: Total three hundred and ninety-five patients were present with coronary artery disease. the level of serum uric acid was high in the patients suffering from coronary artery disease as compared to the patients present without coronary artery disease (5.50 ± 1.00 vs. 5.20 ± 1.00 mg/dL, P= 0.0040). Additionally, there was significant association of serum uric acid with the coronary artery disease severity (P= 0.0020). However, after the adjustment for important confusing factors including DM (Diabetes Mellitus), age, cholesterol level, smoking, metabolic syndrome, PWV and serum uric acid, we found that there was not independent risk factor for incidence of coronary artery diseases (P= 0.1510). On the basis of analysis of subgroup , there was close association of serum uric acid with incidence of coronary artery disease in females as compared to males and in highest quartile ≥ 6.40mg/dL than in initial quartile < 4.80mg/dL; but these results were not much significant (P= 0.0620, P= 0.0750, respectively). According to multivariate regression analysis, Metabolic Syndrome was the most vital determinant of serum uric acid, which has strong association with the incidence of coronary artery disease. Conclusions: In suspected patients of coronary artery disease, serum uric acid was not a risk factor for this complication and it may be simply an indicator of resistance to insulin.
2020
Objective: The aim of this study is to find out an association between the levels or concentration of serum uric acid in the patients present with the suspicion of suffering from CAD (Coronary Artery Disease). Methodology: Study group consisted six hundred and eighty-seven patients with suspicion of coronary artery diseases. All these patients underwent coronary angiography. Stenosis of equal or greater than 50.0% luminal diameter defined coronary artery disease. The expression of the severity of the coronary artery disease was performed as 1-vessel, 2-vessel, or 3-vessel disease. We used the standard of NCEP-ATP 3 (National Cholesterol Education Program-Adult Treatment Panel-3) for MS (Metabolic Syndrome). We obtained the aorto-femoral PWV (Pulse-Wave Velocity) invasively by arterial catheterization. Results: Total three hundred and ninety-five patients were present with coronary artery disease. the level of serum uric acid was high in the patients suffering from coronary artery disease as compared to the patients present without coronary artery disease (5.50 ± 1.00 vs. 5.20 ± 1.00 mg/dL, P= 0.0040). Additionally, there was significant association of serum uric acid with the coronary artery disease severity (P= 0.0020). However, after the adjustment for important confusing factors including DM (Diabetes Mellitus), age, cholesterol level, smoking, metabolic syndrome, PWV and serum uric acid, we found that there was not independent risk factor for incidence of coronary artery diseases (P= 0.1510). On the basis of analysis of subgroup , there was close association of serum uric acid with incidence of coronary artery disease in females as compared to males and in highest quartile ≥ 6.40mg/dL than in initial quartile < 4.80mg/dL; but these results were not much significant (P= 0.0620, P= 0.0750, respectively). According to multivariate regression analysis, Metabolic Syndrome was the most vital determinant of serum uric acid, which has strong association with the incidence of coronary artery disease. Conclusions: In suspected patients of coronary artery disease, serum uric acid was not a risk factor for this complication and it may be simply an indicator of resistance to insulin.
JCR: Journal of Clinical Rheumatology, 2017
The aim of this study was to evaluate relationships between serum uric acid (SUA) and newly emergent acute myocardial infarction (AMI), congestive heart failure (CHF), coronary artery disease (CAD), composite cardiovascular (CV) events (AMI, CHF, CAD), hypertension, hyperlipidemia, and renal disease in gout patients. Methods: Retrospective analysis of electronic medical records from Humedica identified adults (≥18 years) with 2 or more International Classification of Diseases, Ninth Revision, Clinical Modification codes for gout 30 days or more apart (first diagnosis = index event) having 1 or more SUA assessment on or after the index date, and at least 6 months preindex and at least 12 months postindex enrollment. Outcomes were measured during 12 months postindex; patients with preindex events were excluded from analysis of those events. The SUA level (0.01-4.00 mg/dL, 4.01-6.00 mg/dL, 6.01-8.00 mg/dL, and ≥8.01 mg/dL) was determined using the closest laboratory assessment before or on the date of the CV event. Tukey-Kramer comparisons were performed for pairs of SUA strata and Cox proportional model estimated hazard ratios. Results: A significantly higher incidence of AMI, CHF, and renal disease was observed for patients with 8.01 mg/dL or greater relative to other SUA levels (P < 0.0001), and a significantly higher incidence of composite CV events (AMI, CHF, and CAD) was observed for hypouricemia (SUA, 0.01-4.00 mg/dL) compared with other SUA levels (P < 0.0001). Cox models confirmed the increased risk associated with SUA 8.01 mg/dL or greater; hazard ratios ranged from 1.16 for hypertension to 2.04 for renal disease. Hyperlipidemia and hypertension were diagnosed concurrently with gout in 24% and 28% of patients, respectively. Conclusions: Hyperuricemia and hypouricemia were associated with an increased risk of CV events.
Uric acid: a risk factor for coronary atherosclerosis?
Background and objectives: It is uncertain whether high serum uric acid levels are a true independent risk factor for coronary atherosclerosis or whether the association is due to other confounding variables. We therefore studied the relationship between elevated serum uric acid levels and coronary atherosclerosis after adjustment was made for confounding factors such as age, gender, body mass index, smoking, lipid profile, blood pressure and blood glucose levels. Methods: A cross-sectional study was conducted on 240 patients referred for coronary angiography to heart centres in the Shahid-Chamran and Sina hospitals, Isfahan, Iran. Blood chemistry data as well as traditional risk factors and uric acid levels were measured at enrollment. We used vessel, stenosis and extent scores to indicate the degree of coronary artery involvement. Results: This study was conducted on 240 patients with a mean age of 56 ± 10.9 years (66% male; 37% female) who underwent coronary angiography. Student’s t-test analyses revealed that there were significant differences in the mean uric acid levels between male and female patients (p = 0.001). We found no statistically significant correlation between serum uric acid levels and coronary atherosclerosis (p > 0.05). In addition, multivariate logistic regression analyses, using coronary atherosclerosis as dependent variable and traditional risk factors and uric acid levels as independent variables, did not show any significant difference. Conclusion: These findings indicated that uric acid is not associated with coronary atherosclerosis. Any correlation reported in other studies was probably due to the relationship between high serum uric acid levels and other cardiovascular risk factors.