Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae) (original) (raw)
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Revista de Chimie, 2022
Phytochemical analysis of the leaf extract of Zanthoxylum caribaeum Lam (Family Rutaceae) collected in the La Garita district, Municipality of Los Patios in Norte de Santander, Colombia, is reported. Ethanolic extracts by simple maceration were concentrated at reduced pressure. Secondary metabolites found in preliminary identification demonstrated the presence of of alkaloids, tannins, carotenoids, anthocyanins, coumarins, cardiotonics, flavonoids, quinones, saponins, sesquiterpen-lactones, and triterpenoids. Gas chromatography mass spectrometry analysis identified the presence of ten compounds, with a-trans-farnesene (33.5%) as the main constituent, followed by trans-a-caryophyllene (28.1%), S-cadinene (9.7%), caryophyllene oxide (8.3%) and a-muurolene (8.1%). Some of these compounds have been reported with biological properties such as antiparasitic, antimicrobial or cytotoxic, so Zanthoxylum caribaeum is a promising species in the Department of North Santander as a source of comp...
PHYTOCHEMICAL ANALYSIS OF PLANT SPECIES OF GENUS ZANTHOXYLUM
The present article illustrates phytochemical investigations carried out on three plant species i.e. Zanthoxylum armatum (D.C), Zanthoxylum oxyphyllum (Edgew) and Zanthoxylum rhetsa (Roxb.) (D.C). Percent yield of the crude ethanolic extracts from Zanthoxylum armatum (Leaves), Zanthoxylum oxyphyllum (Leaves), Zanthoxylum oxyphyllum (Seeds), Zanthoxylum rhetsa (Leaves), Zanthoxylum rhetsa (Seeds) were 7.78%, 9.85%, 14.1%, 9.23%, and 14.21% respectively. The qualitative analysis showed the abundance of Glycosides, Coumarins, Flavonoids, Phenols, and Tannins in crude ethanolic extracts of ZAL, ZOL, ZOS, ZRL, and ZRS. Thus, the preliminary phytochemical screening revealed the presence of medicinally important constituents in the plants studied. Phenolic content was found maximum in leaves of Zanthoxylum oxyphyllum followed by leaves of Zanthoxylum armatum. Seeds of Zanthoxylum rhetsa showed maximum concentration of Flavonoid followed by leaves of Zanthoxylum armatum. The present qualitative and quantitative analysis explores the wider possibility of efficient and productive extraction of different secondary metabolites from crude ethanolic extracts of ZAL, ZOL, ZOS, ZRL, and ZRS. KEYWORDS: Phytochemical Screening, Zanthoxylum armatum (D.C), Zanthoxylum oxyphyllum (Edgew) and Zanthoxylum rhetsa (Roxb.) (D.C)
1970
The members are trees, shrubs, lianas, or rarely herbs, often with spines or prickle and with secretary glands containing ethereal oils in many tissues and appearing as pellucid-punctate glands in the leaves and pericarp [3]. The genus Zanthoxylum L. with 225 tropical species is a rich source of various phytochemicals such as amides, alkaloids, flavanoides, lignans, sterols and terpenes, etc. Many species of genus Zanthoxylum (Z. acanthopodium DC.
Chemical Composition and Biological Screening of Essential Oils of Zanthoxylum armatum DC Leaves
Journal of Clinical Toxicology, 2014
The chemical composition and biological screening of the essential oils of the gall of Pistacia integerrima was performed. Volatile chemical constituents were obtained by hydrodistillation followed by liquid-liquid extraction. The oil was found rich in 1-Tepinen-4-ol (28.82%), p-meth-1-en-8-ol, (43.38%), n-Octyl acetate (19.91%), and beta-Farnesene (7.88%). The concentration of α-terpinolene, limonene and α-thujene were less than 1%. The essential oils at the tested concentration (10, 100 and 1000 μg/ml) showed moderate to maximum phytotoxic effect. The maximum effect was observed with 1000 μg/ml (80%) followed by 100 μg/ml (60%) and 10 μg/ml (50%). The tested oils exhibited promising antibacterial activities. The zone on inhibition against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Straptodirimu, Bacillus stearothermophilus and Salmonella typhimurium was 16, 18, 26, 22, 18 and 20 mm, respectively. In case of antioxidant activity, the oils exhibited a concentration dependent free radical scavenging effect.
WJPR, 2024
This study examines the phytochemicals of Zanthoxylum armatum, a medicinal plant known for its antibacterial, antioxidant, and antiinflammatory properties. The plant, also known as Timur in Nepal, is used in indigenous Asian practices. Its therapeutic efficacy is attributed to its use in fruits, leaves, stems, bark, and roots. The study utilized solvents like chloroform, ethanol, and methanol for extracting plant fruit, followed by hydro distillation for essential oils. The phytochemicals were analyzed qualitatively, with antioxidant properties assessed using DPPH free radical scavenging, antibacterial activities determined using disc diffusion, and anti-inflammatory activity determined using human RBSs membrane stabilization. The study reveals the presence of alkaloids, steroids, flavonoids, terpenoids, tannins, and saponins in methanolic extracts, while carbohydrates are absent, and these compounds are also present in ethanolic extracts. The different solvent extracts showed ZOI for all the tested bacteria at the range of 6-11 mm. The antibacterial potency of the extracts was found to be concentration-dependent. The bacterial activity of essential oil against S. typhi and S. aureus was found to be more sensitive than Azithromycin and Ciprofloxacin. The bacterial activity of methanolic extracts of Z. armatum against KLE was found to be more sensitive than Azithromycin and Ciprofloxacin. The chloroform extract of Z. armatum exhibited low antioxidant activity, while the ethanolic
Antibacterial and antioxidant effects of Zanthoxylum armatum DC extracts
Bangladesh Journal of Botany
Antibacterial and antioxidant activities of three different extracts (acetone, methanol, and n-hexane) of Zanthoxylum armatum fruits and leaves were investigated. The maximum inhibition zone was shown by methanolic leaf extract against K. pneumonia (20.51 ± 0.93). The minimum inhibition zone (12.01 ± 0.93) was exhibited by methanolic fruit extract against S. typhi. The highest antioxidant activity was recorded at 1000 ppm. Methanolic leaf extract was the most antioxidant (89.8%) among all the extracts, followed by methanolic fruit extract (88.6%). The methanolic and acetonic extracts showed good antibacterial activity as compared to n-hexane extracts and n-hexane was less antioxidant.
Journal of medicinal plant research
This paper compile a review on pharmacological studies, phytochemical analysis and problem associated with Zanthoxylum armatum DC. The different plant parts like leaves, fruits, stem, bark, seeds and roots are used in indigenous medicine preparation against various diseases. It shows antioxidative, antitumor, antiinflammatory, analgesic, antimicrobial and insecticidal/larvicidal activity. For their bioactive principles extensive chemical analysis resulted in this specie. Due to significant medicinal properties and continuous increasing demand put this plant in endangered category (IUCN). This plant has effective phytomedicinal action.
Journal of Ethnopharmacology, 2013
Cite this article as: L.N. Misra, Wouatsa N.A. Vyry, Shiv Kumar, Venkatesh KumarR. , Tchoumbougnang Francois, Antibacterial, cytotoxic activities and chemical composition of fruits of two cameroonian zanthoxylum species, Journal of Ethnopharmacology, http://dx.
Revista Brasileira de Saúde e Produção Animal, 2017
The present study aimed to identify and quantify the components of the essential oil of Zanthoxylum caribaeum and to evaluate the antimicrobial potential of different plant extracts and the essential oil of this plant against different serotypes of Salmonella enterica, which is of greater occurrence and isolated in the western region of Paraná, Brazil. The extraction of the essential oil was performed using Clevenger apparatus and the chemical composition was determined by Gas Chromatography coupled to Mass Spectrometry (GC-MS). The extracts were obtained through different solvents (ethanol, methanol, hexane, acetone, dichloromethane, ethyl acetate and distilled water). The antibacterial activity was carried out according to the broth microdilution technique. The GC-MS analysis resulted in the identification of 15 main components, all terpenes, representing 63.88% of the total essential oil. The major compounds identified were Germacrene-D (20.77%), α-Panasinsene (14.40 %) and β-Selinene (11.68 %). The essential oil presented antibacterial activity against 5 serotypes of Salmonella enterica, with MIC and MBC ranging from 7000 to 437 µg.mL-1. While MIC and MBC from the range from 200 to 25 mg.mL-1 , being effective to most serotypes of S. enterica, with the exception of the aqueous extract. The results suggest that the essential oil and leaf extracts of Z. caribaeum Palavras-chave: concentração bactericida mínima, concentração inibitória mínima, cromatografia gasosa, microdiluição, produtos naturais
Chemical Constituents and Biological Activities of the Genus Zanthoxylum: A review
The three Tanzanian wild mushroom species Termitomyces letestui, Lactarius edulis and Agaricus sp. aff. arvensis yielded ergosterol, 5,8-peroxyergosterol and ergosta-5,22-dien-3!-ol, and a mixture of ergosterol, ergosta-7,22-dien-3!-ol and ergosta-7-en-3!-ol whose composition was deduced from gas chromatography/mass spectroscopic (GC/MS) analysis of the trimethysilylated mixture. GC/MS analysis of the lipid fraction from T. letestu revealed the presence of linoleic (C18:2), stearic (C18:0), oleic (C18:1), palmitic (C16:0), pentadecanoic (C15:0) and myristic (C14:0) acid. Polar T. letestui and L. edulis fractions yielded ","1,1#$trehalose and mannitol. Some of the crude extracts from the three mushroom species showed mild antimicrobial, mosquito larvicidal and cytotoxic activities. The chemical composition and antimicrobial activities infer that the three mushroom species are potential functional food substrates.