Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli (original) (raw)

Abstract

Significance Staphylococcus aureus is a ubiquitous pathogen that causes disease in a variety of tissues. Our studies provide insight into how this pathogen uses the SaeS sensor kinase to recognize innate immunity signals and induce a transcriptional response tailored for its environment. Our results demonstrate that the specificity of these responses is determined by individual amino acids predicted to be in an extracellular domain. These amino acids include aromatic anchors and a methionine residue essential for activation of target gene transcription and virulence. Our findings provide a putative mechanism for the ability of bacterial sensory systems to integrate and diversify the responses to host stimuli. They underscore the exquisite nature of bacterial signaling and the complexity of host-pathogen interactions. Two-component systems (TCSs) are highly conserved across bacteria and are used to rapidly sense and respond to changing environmental conditions. The human pathogen Sta...

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