Comparison of the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis (original) (raw)
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Iranian Red Crescent Medical Journal
Background: Vulvovaginal candidiasis (VVC) is a very common debility in gynecology clinics. Despite access to several antifungal agents, VVC is still a challenge; therefore, presenting a novel antifungal agent, especially with a traditional origin, is of interest and demand. Objectives: The current study aimed at comparing the efficacy of Anethum graveolens L. (dill) vaginal cream with that of 1% Clotrimazole vaginal cream to treat VVC. Methods: A prospective, single-center, randomized, double-blind clinical trial was performed. In the current study, married females aged 18-65 years, with probable vulvovaginal candidiasis were enrolled for primary evaluation. After VVC confirmation by the sniff test, the patients were allocated into three groups with regard to blocked randomization, and inclusion and exclusion criteria. The first group (n = 59) was treated with 1% Clotrimazole vaginal cream; the second (n = 60) with a combination of dill seed essential oil and dried aqueous extract vaginal cream (TEE); and the last (n = 56) with dill seed essential oil vaginal cream (EO) for seven nights. After 10 days, the therapeutic effects were assessed. Results: After the intervention, itching decreased to 30.5%, 3.3%, and 12.5% in the Clotrimazole, TEE, and EO groups, respectively; the sniff test also decreased to 33.9%, 13.3%, and 12.5%, respectively. Although a statistically significant difference, according to itching and sniff test, was observed among the three groups (P < 0.001, P = 0.005), there was no significant difference between TEE and EO (P = 0.06). Conclusions: The current study showed that the herbal preparation could be used as an alternative antifungal agent for vulvovaginal Candidiasis.
Herbal Medicine and Vaginal Candidiasis in Iran: A Review
Evidence Based Care, 2017
Candidiasis is the second most common vaginal infection. Given the frequent recurrence of the disease, many women tend to use herbal remedies. Thus, the present study aimed to review the association between vaginal candidiasis and herbal medicines in Iran. In this review, we retrieved articles published from 2001 to 2016. Then, the results were expressed both quantitatively and qualitatively. In this study, nine articles were reviewed, which had investigated thyme, garlic, garlic-thyme, olive oil, propolis, myrtus, Nigella sativa (black cumin), and Bunium perscicum boiss (black zira). Subsequently, each of these plants was thoroughly dealt with. The studies on black cumin, garlic, and thyme reported positive effects for these herbs, and they were widely produced for therapeutic purposes. In addition, myrtus was found to have a salutary impact on vaginal candidiasis.
Journal of Advanced Pharmaceutical Technology & Research, 2017
Vulvovaginal candidiasis is one of the most common infections of the genital tract in women that causes many complications. Therefore, we examined the clinical effect of ginger cream along with clotrimazole compared to vaginal clotrimazole alone in this study. This double-blind clinical trial was conducted on 67 women admitted to the Gynecology Clinic of Hajar Hospital with vaginal candidiasis. The patients were divided randomly into two groups of 33 and 34 people. The diagnosis was made according to clinical symptoms, wet smear, and culture. Ginger-clotrimazole vaginal cream 1% and clotrimazole vaginal cream 1% were administered to groups 1 and 2, respectively, once a day for 7 days and therapeutic effects and symptoms were evaluated in readmission. Data analysis was performed using SPSS version 22, t-test and Chi-square. The mean value of variables itching (P > 0.05), burning (P > 0.05), and cheesy secretion (P < 0.05) in users of ginger-clotrimazole was less than the oth...
Evidence-Based Complementary and Alternative Medicine
Background and Objective. Vulvovaginal candidiasis (VVC) is one of the most troublesome opportunistic infections in women. In recent years, its prevalence has increased significantly because different types of Candida yeast are resistant to common antifungal medications, supplements, and herbs have become common. This research aimed to compare the effects of N. sativa-honey vaginal cream and 1% clotrimazole on VVC. Materials and Methods. This triple-blind, randomized controlled trial was conducted on eighty-four 18 to 49-year-old nonpregnant women from August 2019 to February 2020. The subjects were randomly divided into two groups after confirming the diagnosis of VVC infection through fungal culture. Clinical signs and symptoms and lab tests were recorded at baseline and 6–10 days after treatment. The treatment time for each group was seven nights. Results. There were no significant differences in clinical and laboratory evaluations between the two groups at the beginning of the s...
Acta Facultatis Medicae Naissensis
Candida vaginitis is the second most common vaginal infection which is treatable by azole. Overconsumption of azole is associated with resistance to drug and treatment failure. Studies conducted in laboratory conditions confirm the anti-fungal effects of Artemisia plant. The aim of this study was to compare the effect of vaginal Artemisia cream and clotrimazole on vaginal candidiasis infection. This is a clinical triple-blind trial that was performed on 72 non-pregnant women referred to Mashhad health centers in 2012-2017. After confirmation of Candida infection, the research units were randomly allocated into two groups: Artemisia and clotrimazole vaginal cream recipients treated for 7 nights. After the treatment, the data were analyzed by SPSS software (version 24). The results of the study showed that the mean reduction in the score of signs and symptoms of vaginal Candida infection was 7.4 ± 4. 1 and 7.6 ± 3.8 in the Artemisia and clotrimazole group, respectively. Wilcoxon test ...
Comparison of Vaginal Cream of Coconut Oil and Clotrimazole on Candidal Infection of Vagina
Journal of Babol University of Medical Sciences, 2019
BACKGROUND AND OBJECTIVE: Candidiasis is the second common vaginal infection, and commonly used drugs are azoles. Over-consumption of Azol is associated with resistance to drug and treatment failure. Studies conducted in vitro confirm the antifungal effects of coconut oil. The aim of this study was to compare the effect of vaginal cream of coconut oil and clotrimazole on vaginal candidiasis infection. METHODS: This clinical trial study was performed on 71 women with Candida infection in two groups receiving vaginal cream of coconut oil: 35(78%) and clotrimazole (36%) (1%) who were treated for 7 nights (one applicator per night). One week after the completion of the treatment, patients were reexamined. Itching, burning, pain and secretion were compared in two groups. FINDINGS: After the mean intervention (itching in the coconut group was 0±0 and in the clotrimazole group was 19±0.46 (p=0.017), (burning in the coconut group was 0.08±0.20 and in the clotrimazole group was 57% (p=0.046), (secretion in the coconut group was 0.05±0.23 and in the clotrimazole group was 66.6±0.98 (p=0.001) (pain during sex in the coconut group 23 0.05 and 0.30±0.62 in the clotrimazole group (p=0.031). However, the success of the treatment (negative culture) was not significant between the two groups (p<0.05). CONCLUSION: The present study showed that vaginal cream of coconut oil and clotriamzole both improve vaginal candidiasis infection. Therefore, vaginal cream of coconut oil can be used as an alternative treatment for vaginal candidiasis.
Afro-Egyptian Journal of Infectious and Endemic Diseases (Online), 2022
Background and study aim: Candida species is a leading cause of recurrent inflammation of both the vagina and vulva known as vulvovaginitis. The increasing occurrence of vulvovaginitis among women of reproductive years makes it important to investigate the risk factors associated with vulvovaginitis and the antifungal effect of selected plant extracts on Candida species associated with vulvovaginitis. Materials and Methods: Three hundred women of reproductive age (15-50 years) with complaints suggesting vulvovaginitis were assessed for possible risk factors associated with vulvovaginitis. High Vaginal swabs (HVS) were collected and cultured for the presence of Candida species on Sabouraud Dextrose Agar (SDA). Colonies were identified based on colony morphology, germ tube test, and biochemically using API 20C AUX. Agar-well diffusion was used to determine the effect of Gomphrena celosioides and Vernonia perrottettii extracts on the isolates. Chi square (P<0.05) was used to determine the factors associated with vulvovaginitis. Results: There was a significant association (P<0.05) with the use of birth control pills, tight underwear, tight clothing, pregnancy and vulvovaginitis. (χ2= 82.78, P<0.001, χ2= 23.06 P<0.001, χ2= 8.292 P<0.004, χ2 = 30.95 P≤0.0001 respectively). Twenty-one (21) isolates of Candida species were identified as Candida tropicalis 13(59.1%)), Candida glabrata 3(13.6%), Candida albicans 3(13.6%), Candida parasiplosis 1(4.6%) and Candida lambica 1(4.6%).. Conclusion: The study demonstrates that birth control pills, tight underwear, tight clothing and pregnancy had a significant association with vulvovaginitis. All Candida species isolates were resistant to plant extracts. Women should be educated on the risk factors associated with vulvovaginitis.
A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
Healthcare
Background: An estimated 75% of women will have one episode of vulvovaginal candidiasis (VCC) during their lifetime, and 40–50% of these will experience further episodes. The high incidence of vulvovaginal candidiasis, combined with the problems of azole resistance and toxicity, highlights the necessity for new strategies for the treatment of this condition. In this context, natural compounds represent promising alternatives. Methods: We enrolled, between January 2020 and April 2021, forty women affected by uncomplicated vulvovaginal candidiasis. Women were divided into two groups. In the first group, we treated 20 women with clotrimazole daily administration for six days. In the second group, 20 women were treated with clotrimazole associated with Unilen® Microbio+, a new product containing Saccharomyces cerevisiae, melatonin, and GLA-14. Women underwent a check at days 15, 30, and 90. A clinical and cultural examination were performed to establish the effect of the treatments on v...
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Candida vulvovaginitis is one of the most common infections of the female at reproductive age that affects the quality of their life. Antifungal effects of honey, yogurt and the tendency of using herbs has encouraged us to conduct this study. This study was done to determine the effects of yogurt & honey and honey vaginal cream on the symptoms of vaginitis. METHODS In this randomized, triple blind clinical trial of 105 non-pregnant women with candida vulvovaginitis were placed in three groups of vaginal cream, mixture of yogurt and honey recipients (N = 35), honey vaginal cream (N = 35) recepients and clotrimazole vaginal cream (N = 35) recipients. Each group was treated for 7 days. At the beginning of study, clinical and laboratory signs and symptoms were registered 7 and 14 days after treatment by questionnaire, observation forms and culture results of secretions. Data by chi-square test, analysis of variance (ANOVA), McNemar's tests were analysed by Statistical Package for the Social Sciences (SPSS) version 21. Significance level of 0.05 was considered. RESULTS There are significant differences in symptom improvement of "yogurt and honey", "honey" than "clotrimazole group" (p < 0.05) and also positive results of the first cultures (one week after treatment) in "yogurt and honey", "honey" and "clotrimazole" (31 / 4 %, 37 / 1 % versus 20 %) and second time cultivation (14 days after treatment) (28 / 6 %, 31 / 4 % versus 14 / 3 %) were similar and there were no significant differences between the two groups. (P > 0.05). CONCLUSIONS Therapeutic effects of honey, and yogurt-and-honey are not only similar to that of clotrimazole vaginal cream, but are more effective in relieving some symptoms of vaginal candidiasis. Therefore, use of this product can be suggested as a herbal remedy for candida infection treatment.