1974-2014: Reflections on the evolution of clinical pharmacology in the past 40 years and a message to our readers (original) (raw)

Methods in clinical pharmacology - a tale of two worlds

British Journal of Clinical Pharmacology, 2008

Video Clip S1. A Career in Pharmacology. The video clip is in Quicktime. Video Clip S2. Pharmacology at the National Institute of Medical Research 1948. The video clip is in Quicktime. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article.

Progress in Drug Research

2001

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The clinical pharmacology section of the International Union of Pharmacology

Clinical pharmacology and therapeutics, 1987

The discipline of clinical pharmacology involves the scientific evaluation of drugs and their rational use in humans. As practitioners of the discipline, we increasingly develop the theme of individualizing therapy for the sick and practice our profession in our own locality and country, but we must not forget our wider international responsibilities and have concern for population, in addition to individual, well-being. We must remind ourselves that the battle for the minds and hearts of physicians, bureaucrats, and politicians over rational drug use is being waged not only at home but in every country and region of the world. The pressures of public demands and fiscal restraints, the inadequacies of our educational programs, the availability of useless and dangerous chemical entities, and irrational patterns of drug use are ever present. As we develop and implement

Pharmacology, basic & clinical: contrasts & coherence

British Journal of Clinical Pharmacology, 2009

Clinical and basic pharmacology share much common ground-unsurprisingly so, in view of the common ancestries of humans, other mammals, and more primitive life forms.There are also, however, important differences.Some of these relate to cultural differences between clinical and basic pharmacologists, and such barriers are best broken down: pharmacologists are much more influential if they speak with one voice. In this spirit, the clinical specialty in the UK is represented by the clinical section of the British Pharmacological Society (BPS-the owner of this journal as well as of the British Journal of Pharmacology (BJP) and of Pharmacology Matters) as its specialist society, and national meetings of the clinical section occur during a scientific meeting of the BPS (in recent years, the winter meeting). Clinical pharmacologists pull their weight in the Society and are recognised accordingly: for example, Jeff Aronson is currently President of the BPS and Colin Dollery was the 2007 winner of the Wellcome Gold Medal of the Society. There are, however, real (as well as cultural) differences between these branches of the discipline, and this editorial view comments on some of these. We plan to revisit the relationship between clinical and basic pharmacology more formally soon (see below). Basic pharmacologists choose their experimental preparations with the greatest care and minimize potential sources of variation. Species, age, sex, conditions of anaesthesia for in vivo work, instrumentation, and so on are all standardized within tight limits.This applies even (or especially) when investigating the effect of a drug on an experimental model of a human disease that is the ultimate therapeutic target. Error bars are accordingly tight, even with only modest numbers of replicate experiments. Clinical pharmacologists by definition work with human preparations-indeed often with conscious subjects, who do not come in inbred lines but rather in a bewildering array of ages, sizes, and ethnicities, who suffer from diverse acute and chronic diseases that each encompass a wide spec

Basic Pharmacokinetics Michael C. Makoid, Ph.D. Phillip J. Vuchetich, Pharm.D. Candidate

When I first started teaching, I had the good fortune to work with another new Ph.D., John Cobby. We struggled through our first five years on the otherside of the podium together and learned many of the tenents upon which this book is based, not content but process. First and formost, it was his belief that students are bright, enthusiastic and hardworking. We should tell them what to do and get out of their way. We both prepared extensive handouts complete with even more extensive practice problems so that the student could experience the scientific method as a detective might solve a murder mystery. The idea was to make learning pharmaceutical science interesting and fun. Through the years, as the methods became more refined, student perceptions and performance improved dramatically.

2 General Principles of Pharmacology

2003

1. Progress in Therapeutics 3 Robert E. Stitzel and Joseph J. McPhillips 2. Mechanisms of Drug Action 10 William W. Fleming 3. Drug Absorption and Distribution 20 Timothy S. Tracy 4. Metabolism and Excretion of Drugs •• Timothy S. Tracy 5. Pharmacokinetics •• Timothy S. Tracy 6. Drug Metabolism and Disposition in Pediatric and Gerontological Stages of Life •• Jeane McCarthy 7. Principles of Toxicology •• Mary E. Davis and Mark J. Reasor 8. Contemporary Bioethical Issues in Pharmacology & Pharmaceutical Research •• Janet Fleetwood