Microsphere as a novel drug delivery (original) (raw)
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MICROSPHERES: AS NEW DRUG DELIVERY SYSYTEM
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion.
Microsphere: A Novel Drug Delivery System
International journal of pharmacy and technology, 2020
Microspheres are normally free flowing powders contains proteins or synthetic polymers which has biodegradable in nature and having a particle size but 200-500 μm. Number of techniques for the preparation of microspheres offers a spread of opportunities to regulate aspects of drug administration and enhance the therapeutic efficacy of a drug. A neat controlled drug delivery system can overcome a number of problems of conventional therapy and enhance therapeutic efficacy of the drug. There are various approaches in delivering therapeutic substance to the target site in sustained and controlled release fashion. These are prepared by methods like Single emulsion, Double emulsion, Polymerization, Phase separation coacervation, Emulsion solvent evaporation and solvent diffusion. Microspheres are having wide selection of applications due to controlled and sustained release.
MICROSPHERES AS A NOVEL DRUG DELIVERY SYSYTEM -A REVIEW
Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 µm. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest without untoward effects. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs to the tumour. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.
Microsphere A Novel Drug Delivery System – A Review
International Journal of Scientific Research in Science and Technology, 2023
The microspheres are also called as micro-particles. Microspheres are characteristically spherical & free flowing powders having particle size ranging from 1-1000μm consisting of proteins or synthetic polymers. Microsphere can be manufactured by various type of material such as glass, polymers, and ceramic microspheres Microspheres are used in drug delivery systems to overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug they are designed. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. At the target tissue the drug should deliver in an optimal amount in the right period of time with the minimum side effect & maximum therapeutic effect, to get the desired effect. The microspheres received much attention not only for the prolonged release or controlled drug delivery to improve bioavailability, stability and action at the specific site to predetermined rate but also for targeting of the anticancer drugs to the tumour. Microspheres are various types like Bioadhesive microspheres, Magnetic microspheres, Floating microspheres, radioactive microspheres, Polymeric microspheres, Biodegradable polymeric microspheres, Synthetic polymeric microspheres. The microsphere are spherical microparticles & are used where predictable & consistent particle surface area is important. The microspheres has the drug located centrally within the particle where it is encased within the unique polymeric membrane. This review focuses on types, materials used, drawbacks, advantage & disadvantage.
-Microspheres as a novel drug delivery system-a review
International journal of pharmaceutical sciences review and research, 2022
Controlled drug delivery system can conquer the issues of conventional drug therapy and gives better therapeutic efficacy of a drug. The microspheres are one of the novel drug delivery system which can be given as an effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Microspheres are spherical free flowing powder having particle size less than 200µm, consisting of synthetic polymers and proteins which are biodegradable in nature. Microsphere improves bioavailability, reduces the side effects, improves stability, decreases dose frequency and targets the drug to specific site at predetermined rate. The different types of microspheres are bioadhesive, floating, radioactive, polymeric and biodegradable microspheres. In future microspheres will track down the focal spot in novel drug delivery conveyance, especially in diagnostics, genetic materials, targeted and effective drug delivery.
Microspheres: As a Carrier Used for Novel Controlled Drug Delivery System: A Review
Microspheres are small spherical particles that consisting of proteins, synthetic or natural polymers having particle size less than 200μm. Synthetic polymers are biodegradable in nature. A microsphere is a homogeneous structure made of a continuous phase of one or more miscible polymers in which particulate drug is dispersed throughout matrix at either macroscopic or molecular level. These drug delivery provide a therapeutic amount of drug to the target site in the body in sustained and controlled release system which improve the bioavailability, therapeutic efficacy and reduce the adverse effect of drug. Microspheres used to delivered the drug to the target site with specificity, particularly in safe, targated and effective In-Vivo delivery, gene and genetic materials, diagnostics, diseased cell sorting.
Microspheres constitute an important part of novel drug delivery system by virtue of their small size and efficient carrier capacity. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs also known as micro particles. It is the reliable means to deliver the drug to the target site with specificity, if modified, and to maintain the desired concentration at the site of interest. Microspheres received much attention not only for prolonged release, but also for targeting of anticancer drugs. The purpose of the review is to compile various types of microspheres used in the formulation of microsphere drug delivery system and its applications
Microsphere: a promising approach for drug delivery
Journal of Applied Pharmaceutical Research, 2019
The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 μm to 1000 μm (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API. It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day's microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
International Journal of Advances in Pharmaceutics Review on microspheres as a drug delivery carrier
A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. To obtain maximum therapeutic efficacy, it becomes necessary to deliver the agent to the target tissue in the optimal amount in the right period of time there by causing little toxicity and minimal side effects. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. In this article importance of microsphere as a novel drug delivery carrier to attain site specific drug delivery was discussed.
Microspheres: The Efficient Controlled Drug Delivery Carriers
Acta Scientific Pharmaceutical Sciences
Microspheres, free-flowing solid powders are generally made up of biodegradable and biocompatible polymers. Oral, parental, nasal, Ocular, transdermal, colonel, and other routes can be used to administer microspheres with particle sizes ranging from 0.1 to 200 micrometer. Microspheres play a totally vital position as particulate drug transport machine due to their small length and different green properties. Microspheres had been proved to be a appropriate bridge to scale the gap over to formulate an powerful dosage form, to simulate managed drug release. Numerous recent advancements in microspheres, such as mucoadhesive, hollow, magnetic and floating have contributed to overcoming the various challenges connected with their usage such as site specific targeting and enhanced release kinetics. Microspheres will play a key role in novel drug delivery in the future, thanks to a combination of new methodologies, particularly in sick cell sorting, genetic materials, and safe, targeted, and effective drug delivery. Oral modified release microspheres have always proven to be a more effective treatment option than single-unit dosage forms that are released immediately. Multi-particulates are commonly formed into microspheres and filled into hard gelatin capsules as the final dose form. Microspheres have attracted a lot of interest, not just for their long term. It can be used now not excellent for release but moreover for drug targeting. Microspheres will play an increasingly more crucial characteristic in future drug delivery, especially in ailment treatment, diagnosis, genetic material, and targeted effective drug delivery.