Liposarcoma of Laryngeal Vallecula (original) (raw)
Cancer, 1995
Background. Liposarcoma of the head and neck region represents approximately 1% of head and neck sarcomas. Therefore, there are few data on the natural history, presentation, treatment, and prognosis of this neoplasm.
Liposarcoma of the Tongue: Case Report and Review of the Literature
Ear, Nose & Throat Journal
Liposarcoma is the most common soft-tissue malignancy in adults, but the appeara nce ofa liposarcoma in the head and neck region is distinctly unusual. Intraoral liposarcomas represent a pa rticularly interesting subset of this tumor in that (1) they are exceedingly rare and (2) affec ted pat ients tend to have a better prognosis than do pati ents with a similar lesion located elsewhere in the head and neck.An understanding ofthe histologic subtypes and corresponding clinical behavior of liposarcomas will assist physicians in appropriately managing thesepatients. Most of these tumors can be effectively treated with conservative surgery. We repo rt the rare case of a well-differentiated liposarcoma arising in the tongue of a 55-year-old man. We also discuss the typical path ologic findin gs in these malignancies and review the diagnosis, assoc iated controversies, management, and prognosis.
Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
Journal of Zhejiang University-science B, 2010
Atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.
Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience
Head & Neck, 2009
Background. Our aim was to review our experience with liposarcoma of the head and neck region. Methods. This is a retrospective case series at a comprehensive cancer center (1945-2005). Results. Of 30 patients, 10 (33%) were initially misdiagnosed. Local recurrences were common (overall rate 5 53%), and 4 patients (13%) developed distant metastases. Decreased crude disease-specific survival rates were significantly associated with recurrence (especially distant recurrence [0%]), age less than 38 years (40%), and pleomorphic subtype (45%); however, in Kaplan-Meier analyses, only larger tumor size, negative margins, round cell subtype, and pleomorphic subtype were associated with significantly decreased disease-specific survival (log-rank test p 5 .048, .041, .021, and .012, respectively). Conclusions. Based on this limited experience and existing literature, we continue to recommend surgery with negative margins as the treatment of choice and that adjuvant therapies should be considered in patients with high-grade histology, large tumors, positive margins, or certain subsites. V
Liposarcoma of the retropharyngeal space
The Journal of Laryngology & Otology, 2005
Liposarcoma is a common soft tissue malignancy that occurs infrequently in the head and neck. Liposarcoma of the retropharynx is exceptionally rare, only four cases being described in the literature. We present a case in which retropharyngeal liposarcoma occurred in a patient who had had multiple previous subcutaneous lipomas excised. This paper explores this very unusual presentation and discusses the difficulties in the diagnosis and management of this rare tumour.
Laryngeal Lipoma Associated with Diffuse Lipomatosis: Case Report and Literature Review
Ear, nose, & throat journal, 2010
Lipomas are benign mesenchymal tumors that are often found intheheadand neck. Intrinsic lipomas ofthelarynx and supraglottic area are rare, as fewer than 115 cases havebeen reported in theliterature; almostallof these occurredin isolation. Wereport a case ofa laryngeal lipoma that wasassociated with diffusesystemic lipomatosis. The tumor was successfully removed via an endoscopic laser resection. To the best of our knowledge, this is only the secondcase oflaryngeal lipoma associated withlipomatosis to be reported in the English-language literature. Wealso review the literature on head and necklipomas.
Cureus
Liposarcomas are rare mesenchymal tissue tumors and are divided into subtypes based on their histopathological characteristics. They are mostly well-differentiated neoplasms with the tendency to recur locally. Lymph node involvement or distant metastases have been reported as extremely rare. Common manifestations are progressive dyspnea, dysphagia, choking, and stridor. Surgical excision of laryngeal liposarcomas is considered the gold standard treatment modality for disease eradication. In persistent or recurrent cases, a total laryngectomy should be performed. There is much controversy regarding the role of radiotherapy which is mostly used as adjuvant treatment in specific cases. We present a case of dedifferentiated laryngeal liposarcoma with multiple recurrences and metachronous transformation to a neoplasm with myxofibrosarcomatous elements.
Lipomas of Larynx: The Rare Entities
International Journal of Phonosurgery & Laryngology, 2012
Lipoma is the commonest soft tissue tumor arising anywhere in the body, but its occurrence in the larynx is relatively rare. We present a rarest case of lipoma with cartilaginous metaplasia arising from the larynx just above the anterior commissure. The second case report is about a large spindle cell lipoma of larynx presented with stridor. How to cite this article Megalamani SB, Gadag R, Raza A, Satish A. Lipomas of Larynx: The Rare Entities. Int J Phonosurg Laryngol 2012;2(2):79-81.
Well-differentiated liposarcoma of the tongue
Oral Oncology, 2002
Intraoral liposarcomas are rare, with most reported cases being of the myxoid histological type. We present a well-differentiated liposarcoma of the tongue, in a 65-year-old man. The tumour presented lipoblasts in various stages of differentiation, lipocytes in different sizes and shapes, mesenchymal and signet-ring cells. Lipoma, spindle-cell lipoma, myxoma, hibernoma, angiolipoma, fibrolipoma, pseudosarcomatous faciitis and malignant hysticytoma were considered in the diagnosis process. The patient was treated surgically and so far is free of disease. #
Atypical lipomatous tumor of the oropharynx: A case report
Clinical Case Reports, 2022
Atypical lipomatous tumor or well‐differentiated liposarcoma is a rare condition in the laryngopharynx. We present a case of a 63 year‐old male with progressive dysphagia who later manifested with a mass that regurgitates outside the oral cavity. Surgical removal was done via a transoral approach, followed by adjuvant radiotherapy.
Spectrum of liposarcomas-a study of 106 cases
Journal of Ayub Medical College, Abbottabad : JAMC
Liposarcoma is a malignant tumour that arises in fat cells in deep soft tissue. This study was conducted to access the spectrum of liposarcomas This descriptive study was conducted at Armed Forces Institute of Pathology (AFIP), Rawalpindi from 1st January 2008 to 31st December, 2012 and included all the cases diagnosed as liposarcomas. Records of the malignant tumors of soft tissue that presented during this period were analysed and out of this spectrum of liposarcomas were studied. A total of 19367 malignant tumours were diagnosed during study period. Out of these, 615 were malignant soft tissue tumours. Out of these 106 cases were liposarcoma with an overall frequency of 0.54% of the malignant neoplasm and 17.24% of soft tissue sarcomas .The age ranged from 26-85 years. Out of these 106 cases 77 were male and 29 were female with a male to female ratio of 2.6:1. The most common tumour seen was pleomorphic liposarcoma (42.5%) followed by myxoid liposarcoma (22.6%), dedifferentiated ...
Liposarcoma of soft tissue: MRI findings with pathologic correlation
Skeletal radiology, 1997
Objective. To evaluate the MRI findings of liposarcomas of different histologic types and correlate these with the histopathologic features. Design. The MR images of seven liposarcomas were reviewed retrospectively to assess the tumor size, location, margination, signal characteristics and enhancement patterns in different histologic types. Patients. Seven liposarcomas comprising three well-differentiated, two myxoid and two pleomorphic types were evaluated. Results and conclusion. All tumors showed well-defined and mostly lobulated margins. The well-differentiated liposarcomas were composed mainly of fat with septations or nodules, were hyperintense on T2weighted images, and demonstrated faint enhancement or no enhancement following intravenous contrast. Myxoid liposarcomas were homogeneous or mildly heterogeneous and a pseudocapsule was present in one case. Pleomorphic types showed a markedly heterogeneous internal structure. Both myxoid and pleomorphic lesions-showed moderate or marked heterogeneous enhancement after contrast administration. Welldifferentiated liposarcomas may be differentiated from other types of the tumor by their largely lipomatous appearance. The malignancy grade increases in parallel with tumor heterogeneity and contrast enhancement.
Head & Neck, 2020
The aim of this study was to integrate the available data published on Liposarcomas (LPSs) of the oral cavity into an analysis of its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in January 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Forty‐five publications (104 LPSs) were included. The lesion was more prevalent in males from the fifth to seventh decades of life. Treatment (P = .03) and distant metastasis (P = .0001) were independently associated with survival. A lower possibility of recurrence was statistically associated with age (younger patients) (P = .03), tumor size (smaller than 2.8 cm) (P = .001), and treatment (radical surgery) (P = .04). LPS presents a good survival for patients after 5 years of follow‐up (66.4%). Patients who were treated with conservative surgery and presented with distant metastasis showed poor prognosis.
Large Vallecula Lipoma: An unusual clinical entity
Bangladesh Journal of Medical Science, 2016
Lipoma of the oropharynx is an extremely rare entity with less than ten cases reported in so far. We present the case of a 55-year-old gentleman who was referred to our team for an incidental finding of an oropharyngeal mass. Although he did not have stridor despite the mass occupying almost 80% of his oropharynx, he did complain of progressive voice change, feeling of something in the throat and dysphagia over a period of 2 years. The mass was successfully excised endoscopically without the need for a tracheostomy. Airway issues, management options of an oropharyngeal mass, as well as the applied embryology of these lesions are discussed.
Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report
European Archives of Oto-Rhino-Laryngology, 2007
Liposarcoma is one of the most common soft tissue sarcomas in adults. Atypical lipomatous tumour (ALT) rarely occurs in the head and neck region. Histopathologic grade of these tumours aVect prognosis of this disease. The mainstay of treatment for ALT is surgical excision. In this article, a case of a huge ALT arising from the head and neck region and invading nearly entire left hemi-facial region is presented. Clinical and histopathologic features and therapeutic approaches related to this tumour are discussed reviewing the literature.