Liposarcoma of Laryngeal Vallecula (original) (raw)
Related papers
Cancer, 1995
Background. Liposarcoma of the head and neck region represents approximately 1% of head and neck sarcomas. Therefore, there are few data on the natural history, presentation, treatment, and prognosis of this neoplasm.
Liposarcoma of the Tongue: Case Report and Review of the Literature
Ear, Nose & Throat Journal
Liposarcoma is the most common soft-tissue malignancy in adults, but the appeara nce ofa liposarcoma in the head and neck region is distinctly unusual. Intraoral liposarcomas represent a pa rticularly interesting subset of this tumor in that (1) they are exceedingly rare and (2) affec ted pat ients tend to have a better prognosis than do pati ents with a similar lesion located elsewhere in the head and neck.An understanding ofthe histologic subtypes and corresponding clinical behavior of liposarcomas will assist physicians in appropriately managing thesepatients. Most of these tumors can be effectively treated with conservative surgery. We repo rt the rare case of a well-differentiated liposarcoma arising in the tongue of a 55-year-old man. We also discuss the typical path ologic findin gs in these malignancies and review the diagnosis, assoc iated controversies, management, and prognosis.
Clinicopathological features of atypical lipomatous tumors of the laryngopharynx
Journal of Zhejiang University-science B, 2010
Atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.
Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience
Head & Neck, 2009
Background. Our aim was to review our experience with liposarcoma of the head and neck region. Methods. This is a retrospective case series at a comprehensive cancer center (1945-2005). Results. Of 30 patients, 10 (33%) were initially misdiagnosed. Local recurrences were common (overall rate 5 53%), and 4 patients (13%) developed distant metastases. Decreased crude disease-specific survival rates were significantly associated with recurrence (especially distant recurrence [0%]), age less than 38 years (40%), and pleomorphic subtype (45%); however, in Kaplan-Meier analyses, only larger tumor size, negative margins, round cell subtype, and pleomorphic subtype were associated with significantly decreased disease-specific survival (log-rank test p 5 .048, .041, .021, and .012, respectively). Conclusions. Based on this limited experience and existing literature, we continue to recommend surgery with negative margins as the treatment of choice and that adjuvant therapies should be considered in patients with high-grade histology, large tumors, positive margins, or certain subsites. V
Liposarcoma of the retropharyngeal space
The Journal of Laryngology & Otology, 2005
Liposarcoma is a common soft tissue malignancy that occurs infrequently in the head and neck. Liposarcoma of the retropharynx is exceptionally rare, only four cases being described in the literature. We present a case in which retropharyngeal liposarcoma occurred in a patient who had had multiple previous subcutaneous lipomas excised. This paper explores this very unusual presentation and discusses the difficulties in the diagnosis and management of this rare tumour.
Laryngeal Lipoma Associated with Diffuse Lipomatosis: Case Report and Literature Review
Ear, nose, & throat journal, 2010
Lipomas are benign mesenchymal tumors that are often found intheheadand neck. Intrinsic lipomas ofthelarynx and supraglottic area are rare, as fewer than 115 cases havebeen reported in theliterature; almostallof these occurredin isolation. Wereport a case ofa laryngeal lipoma that wasassociated with diffusesystemic lipomatosis. The tumor was successfully removed via an endoscopic laser resection. To the best of our knowledge, this is only the secondcase oflaryngeal lipoma associated withlipomatosis to be reported in the English-language literature. Wealso review the literature on head and necklipomas.
Cureus
Liposarcomas are rare mesenchymal tissue tumors and are divided into subtypes based on their histopathological characteristics. They are mostly well-differentiated neoplasms with the tendency to recur locally. Lymph node involvement or distant metastases have been reported as extremely rare. Common manifestations are progressive dyspnea, dysphagia, choking, and stridor. Surgical excision of laryngeal liposarcomas is considered the gold standard treatment modality for disease eradication. In persistent or recurrent cases, a total laryngectomy should be performed. There is much controversy regarding the role of radiotherapy which is mostly used as adjuvant treatment in specific cases. We present a case of dedifferentiated laryngeal liposarcoma with multiple recurrences and metachronous transformation to a neoplasm with myxofibrosarcomatous elements.
Lipomas of Larynx: The Rare Entities
International Journal of Phonosurgery & Laryngology, 2012
Lipoma is the commonest soft tissue tumor arising anywhere in the body, but its occurrence in the larynx is relatively rare. We present a rarest case of lipoma with cartilaginous metaplasia arising from the larynx just above the anterior commissure. The second case report is about a large spindle cell lipoma of larynx presented with stridor. How to cite this article Megalamani SB, Gadag R, Raza A, Satish A. Lipomas of Larynx: The Rare Entities. Int J Phonosurg Laryngol 2012;2(2):79-81.