Fatal poisonings in Jutland (Denmark) during the 1980s (original) (raw)

Fatal drug poisonings in a Swedish general population

BMC Clinical Pharmacology, 2009

Background: Pharmaceutical drug poisonings have previously been reported using single sources of information, either hospital data or forensic data, which might not reveal the true incidence. We therefore aimed to estimate the incidence of suspected fatal drug poisonings, defined as poisonings by pharmaceutical agents, by using all relevant case records from various sources in a Swedish population.

Drug-related death in Denmark in 2007

Danish Medical Bulletin, 2011

Introduction: We investigated fatal poisonings among drug addicts in 2007. The cause of death, abuse pattern and geographic differences are presented. Material and methods: All drug-related deaths examined at the three forensic medicine institutes in Denmark in 2007 were evaluated. Results: The number of drug-related deaths in 2007 was 226. Methadone deaths had increased since 1997 while heroin/morphine deaths decreased. In earlier studies, very few deaths from central stimulants like cocaine and amphetamines occurred (1-1.5%), but in 2007 6% of the deaths were caused by these drugs. Multiple drug use was common. Heroin/morphine, cocaine, amphetamine, cannabis, methadone, benzodiazepines and alcohol were included in the poly-drug use. Conclusion: This investigation shows stabilization in the number of fatal poisonings in drug addicts. Geographic differences were observed. Methadone was the most frequent cause of fatal poisoning and there was a continuous decrease in heroin/morphine deaths. Fatal deaths from cocaine and amphetamine have increased considerably. Multiple drug use was common. Funding: not relevant. Trial registration: not relevant.

Pattern of acute drug poisoning in Oslo

Acta medica Scandinavica, 1977

All 1742 admissions occasioned by acute drug poisoning to a medical ward in Oslo during the periods 1958--60, 1963--65, 1966--69 and 1970--73 have been reviewed. The number of admissions per annum in these periods was 99, 119, 128 and 144, respectively. Because the hospital situation and number of inhabitants in the city remained fairly constant from 1958 to 1973, the increasing figures were assumed to reflect a corresponding increase in the incidence of acute drug poisoning in Oslo. The incidence was estimated to be within the range of 1--2 per 1000 inhabitants per annum. No female predominance was noted except for the age group under 30 years. The occurrence of barbiturate poisonings decreased markedly during the peroids studied, whereas those due to non-barbiturate hypnotics, tranquillizers and tricyclic antidepressants showed a proportionate increase. Slightly less than one fourth of the females and half of the males had taken alcohol. More males (43%) than females (13%) also we...

Fatal poisonings in Oslo: a one-year observational study

BMC Emergency Medicine, 2010

Background: Acute poisonings are common and are treated at different levels of the health care system. Since most fatal poisonings occur outside hospital, these must be included when studying characteristics of such deaths. The pattern of toxic agents differs between fatal and non-fatal poisonings. By including all poisoning episodes, causefatality rates can be calculated. Methods: Fatal and non-fatal acute poisonings in subjects aged ≥16 years in Oslo (428 198 inhabitants) were included consecutively in an observational multi-centre study including the ambulance services, the Oslo Emergency Ward (outpatient clinic), and hospitals, as well as medico-legal autopsies from 1st April 2003 to 31st March 2004. Characteristics of fatal poisonings were examined, and a comparison of toxic agents was made between fatal and nonfatal acute poisoning. Results: In Oslo, during the one-year period studied, 103 subjects aged ≥16 years died of acute poisoning. The annual mortality rate was 24 per 100 000. The male-female ratio was 2:1, and the mean age was 44 years (range 19-86 years). In 92 cases (89%), death occurred outside hospital. The main toxic agents were opiates or opioids (65% of cases), followed by ethanol (9%), tricyclic anti-depressants (TCAs) (4%), benzodiazepines (4%), and zopiclone (4%). Seventy-one (69%) were evaluated as accidental deaths and 32 (31%) as suicides. In 70% of all cases, and in 34% of suicides, the deceased was classified as drug or alcohol dependent. When compared with the 2981 non-fatal acute poisonings registered during the study period, the case fatality rate was 3% (95% C.I., 0.03-0.04). Methanol, TCAs, and antihistamines had the highest case fatality rates; 33% (95% C.I., 0.008-0.91), 14% (95% C.I., 0.04-0.33), and 10% (95% C.I., 0.02-0.27), respectively. Conclusions: Three per cent of all acute poisonings were fatal, and nine out of ten deaths by acute poisonings occurred outside hospital. Two-thirds were evaluated as accidental deaths. Although case fatality rates were highest for methanol, TCAs, and antihistamines, most deaths were caused by opiates or opioids.

Fatal poisoning in Nordic drug addicts in 2002

Forensic Science International, 2006

The present study from 2002 includes medicolegally examined fatal poisonings among drug addicts in the five Nordic countries: Denmark, Finland, Iceland, Norway and Sweden. A common definition ''drug addict'' is applied by the participating countries. The number of deaths, age, sex, place of death, main intoxicant and other drugs present in the blood are recorded in order to obtain national data, as well as comparable Nordic data and data comparable to earlier studies from 1997 and 1991. The Icelandic results are commented on separately due to the low number of cases.

Self-poisoning with barbiturates in England and Wales during 1959-74

BMJ, 1977

Hospital admissions due to acute barbiturate poisoning per million population in England and Wales have decreased since 1965 at about the same rate as NHS prescriptions for barbiturates. Admissions due to poisoning with other drugs have increased, but, largely because the benzodiazepine hypnotics and tranquillisers are much less toxic than the barbiturates that they are replacing, deaths from poisoning with all solids and liquids have decreased. The risk of death from selfpoisoning associated with each barbiturate prescription has increased two and a half times since 1961, perhaps partly because greater quantities of barbiturate are being dispensed with each prescription and partly because patients for whom these drugs are still being prescribed would, in the event of an overdose, be unlikely to be found and admitted to hospital in time owing to their age and social circumstances. There is now little to justify prescribing barbiturate hypnotics or sedatives for anyone.

Poisoning Casualties: Alcohol, Pharmaceuticals or “Legal Highs”? Poisoning Cases at Emergency Rooms in The Swedish County Värmland in 2007-2013

Journal of Community Medicine & Health Education, 2015

Background: The growing number of novel psychoactive substances (NPS), also labelled as "legal highs", constitutes a challenge to public health. It is uncertain whether this trend is related to the increase in number of poising cases reported by emergency rooms. The aim of this study was to investigate the occurrence of NPS in acute cases of poisoning in the Swedish county Värmland. The numbers of NPS casualties were correlated with poisoning by other substances. Both, the gender and age distribution of the reported cases were recorded. Method: Records classified as poisoning casualties at the emergency rooms in Värmland during 2007-2013 were collected and analyzed. Results: NPS and illicit drugs constituted only a small part (1.67% and 7.84% respectively) of the total poisoning casualties. The results also revealed that alcohol and pharmaceuticals were present in the majority of cases (91.2%), and were to a larger extent involved in polydrug abuse and suicide attempts. Furthermore, the results uncovered an alarming poisoning problem among women who had taken pharmaceuticals and for suicidal young people. Conclusions: It is unclear whether the comparatively low prevalence of NPS and illicit drug related poisoning casualties reflect the real prevalence of injury cases or a possible under-reporting.

Poisoning Casualties: Alcohol, Pharmaceuticals or “Legal Highs”? Poisoning Cases at Emergency Rooms in The Swedish County Värmland in 2007-2013

Background: The growing number of novel psychoactive substances (NPS), also labelled as “legal highs”, constitutes a challenge to public health. It is uncertain whether this trend is related to the increase in number of poising cases reported by emergency rooms. The aim of this study was to investigate the occurrence of NPS in acute cases of poisoning in the Swedish county Värmland. The numbers of NPS casualties were correlated with poisoning by other substances. Both, the gender and age distribution of the reported cases were recorded. Method: Records classified as poisoning casualties at the emergency rooms in Värmland during 2007- 2013 were collected and analyzed. Results: NPS and illicit drugs constituted only a small part (1.67% and 7.84% respectively) of the total poisoning casualties. The results also revealed that alcohol and pharmaceuticals were present in the majority of cases (91.2%), and were to a larger extent involved in polydrug abuse and suicide attempts. Furthermore, the results uncovered an alarming poisoning problem among women who had taken pharmaceuticals and for suicidal young people. Conclusions: It is unclear whether the comparatively low prevalence of NPS and illicit drug related poisoning casualties reflect the real prevalence of injury cases or a possible under-reporting.

Drug-related mortality in Denmark 1970-93

Scandinavian Journal of Public Health, 1999

We analysed drug-related mortality in Denmark with respect to secular trends, gender, and regional variations, for the period 1970 - 93, for all deaths from poisoning and among drug addicts. The study was based on the Register of Causes of Death in Denmark and included 6,229 drug-related deaths, defined by specific combinations of manner of death, underlying cause of death, and contributory cause of death. The main outcome measure is age-specific mortality rate. A total of 63% of the drug-related deaths were registered as unnatural deaths. During the period studied, mortality increased for men in the 25 - 49 year age group and for women in all age groups over 25 years of age. For both men and women, the youngest birth cohorts from the mid-1950s and 1960s suffered much higher mortality than those born before 1950; however, the three youngest birth cohorts had almost the same mortality. During the entire period, mortality in the capital, Copenhagen, was much higher than in the provinc...

Fatal intoxications among non-drug addicts in Eastern Denmark over a five-year period (2003–2007)

Research and Reports in Forensic Medical Science, 2012

Background: This study describes fatal intoxications among non-drug addicts in Eastern Denmark over a five-year period (2003)(2004)(2005)(2006)(2007), and the data are compared with two similar five-year studies from 1992-1996 and 1998-2002. Method and Results: Among 2663 medicolegal autopsies performed during the study period, 428 fatal intoxications in non-drug addicts were detected. Sixty-three percent were caused by pharmaceuticals, 20% by carbon monoxide, and 15% by ethanol. Comparable with previous studies, carbon monoxide, ethanol, methadone, and morphine were the most common fatal substances, although new pharmaceuticals were observed among the ten most lethal substances, such as tramadol. Furthermore, older pharmaceuticals with narrow therapeutic windows such as propoxyphene and ketobemidone were almost not present. This study also briefly mentions alcoholic ketoacidosis as a cause of fatal intoxications. Conclusion: The pattern of fatal intoxications could, for some pharmaceuticals, be related to the number of treatments, although other unknown factors also contribute.