Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases (original) (raw)
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Malignant Pheochromocytoma Lacking Clinical Features of Catecholamine Excess Until the Late Stage
Internal Medicine, 2000
A malignant pheochromocytoma is described in a 71year-old man. Osseous metastases became manifest 12 years after successful removal of the primary tumor which originated in paraganglionic tissue near the right adrenal gland. Although the patient had no symptomsof catecholamine excess initially, hypertension, tachycardia and excessive sweating appeared several months before his death, concomitantly with a sharp increase in noradrenaline secretion due to an accelerated growth of metastatic tumors. Since there is no histologic criterion of malignancy in this neoplasm, it would be prudent to consider every case of pheochromocytomaas potentially malignant and to followup carefully for a long time after removal of the primary tumor.
Malignant Pheochromocytoma: A Case Report
Emergency Medicine: Open Access, 2014
Pheochromocytoma is a tumor of adrenal medulla, derived from catecholamine producing chromaffin cells. Majority of the patients present with headache, palpitations and sweating. It is diagnosed by 24 hour urinary VMA (Vinyl Mendelic Acid) measurements and localization is done by MRI and 123I MIBG scanning. Treatment is essentially surgical with adequate preoperative blood pressure control. Undiagnosed patients can suffer catastrophic consequences while undergoing surgery for some other condition. Ten percent of these tumors are malignant with metastasis to liver, bone and lymph nodes. We present a case of malignant Pheochromocytoma whose VMA level was within normal limits however perioperative findings and histopathology proved it to be malignant.
Malignant pheochromocytoma, still a therapeutic challenge
American journal of hypertension, 1997
For cases of malignant pheochromocytoma the prognosis is poor and experience with its treatment remains limited. We present a case of a hypertensive 16 year old woman with malignant pheochromocytoma and a good treatment response. Bone metastases appeared 6 months after the first resection. Local excision of the thoracic vertebrae metastases and palliative radiation therapy were performed, after which she received twelve cycles of cyclophosphamide, vincristine, and dacarbazine. Sixteen months later the patient remains asymptomatic without biochemical catecholamine activity.
Malignant Pheochromocytoma with Liver Metastases: About A Case
Scholars Journal of Medical Case Reports, 2021
Pheochromocytomas are rare tumors, developed at the expense of the adrenal medulla and paraganglia. The excess of catecholamines secreted leads to clinical symptomatology. The diagnosis of malignancy is made only by the presence of metastases from organs devoid of chromaffin tissue or by the appearance of neoplastic recurrences. A 20-year-old woman was reported to have hypertensive crises with cerebral and ocular repercussions. A malignant pheochromocytoma of the left adrenal gland with hepatic metastases was diagnosed and the patient underwent left adrenalectomy with hepatic metastasectomy and surgical portal embolization in preparation for a subsequent right hepatectomy.
Oman Medical Journal, 2015
heochromocytoma is a rare but lifethreatening condition that has varied clinical presentations particularly hypertension, headache, palpitation, and sweating. 1,2 Patients with suggestive clinical features are frequently tested for pheochromocytoma. The medical interest in this tumor has increased with the improved availability of diagnostic laboratory tools particularly plasma or urinary fractionated metanephrines (metanephrine and normetanephrine), and other neuroendocrine markers particularly chromogranin A. 3,4 The wide universal availability of different imaging facilities, both anatomical and functional, has also improved the detection of pheochromocytoma. 5 The growing awareness for implementing different protocols and guidelines that consider pheochromocytoma in the work-up and differential diagnosis has improved diagnosis of the disorder. 6 Accurate diagnosis is important because if the tumor is detected early laparoscopic or surgical treatment is usually curative before other changes or complications take place. Catecholamine-producing tumors are neuroendocrine tumors that affect the chromaffin cells of adrenal medulla and postganglionic fibers of case report
World journal of surgery
This study aims to examine the frequency of the pheochromocytoma (pheo), defined as a "benign, intra-adrenal, hypertensive, sporadic, unilateral tumor." Three large series amounting to 310 subphrenic chromaffin tumors operated over periods of 17, 23, and 41 years, respectively, have been reviewed. Among those combined 310 pheos, 48 (15.5%) were malignant (i.e., metastatic) and 262 (84.5%) were benign; 42 (13.5%) were ectopic (35% of malignant tumors versus 9.5% of benign tumors); 230 (74.2%) were hypertensive (74% of benign tumors versus 73% of malignant tumors); 29 (9.4%) were bilateral, including 23 patients with a family history; 41 (13.2%) of patients had MEN II type A or B syndrome; and 20 (6.5%) occurred in a phacomatosis setting. Some of the patients had a non-MEN family history of pheo (n = 5), seemingly sporadic hyperparathyroidism (n = 4), or other associated neuroendocrine tumor (n = 9). Sometimes several of these features were combined. Finally 125 (40.3%) case...
A giant malignant pheochromocytoma of the adrenal gland: biologic time bomb
The Internet Journal of Oncology, 2009
BACKGROUND:Pheochromocytoma is a rare tumor of adrenal medulla and only 5-10% of pheochromocytoma are malignant. Surgical resection is the only mode of treatment .Methods:A case report with review of literature is presented in briefResults: Overall prognosis in benign case: 5 yr survival rate is >90% and in malignant case: about 40%
A Pheochromocytoma with Liver Metastasis: What about Curative Surgery?
Journal of Advances in Medicine and Medical Research
Introduction: 35% of pheochromocytomas are malignant and generally have a poor prognosis.Visceral metastases are associated with shorter survival. Treatments for advanced pheochromocytomas are essentially palliative. Surgery is potentially curative; however, tumor extension limits the chance for a curative resection. Case Presentation: A 21-year-old women presented to our hospital with severe hypertension associated with Ménard's triad and heaviness of the left flank.The abdominal CT scan discovered a left adrenal mass with liver metastases. The diagnosis of pheochromocytoma was confirmed biochemically by the elevated catecholamine and metanephrine levels in the blood and urine. After preparation by the alpha-adrenergic blockade, she underwent left adrenalectomy and resection of left liver metastases followed by right hepatectomy. A pathology examination was performed and the final report was a metastatic pheochromocytoma with negative margins. She was discharged on postoperativ...
Adrenal Pheochromocytoma -A Case Presentation with Review of Literature
https://www.ijhsr.org/IJHSR\_Vol.12\_Issue.8\_Aug2022/IJHSR-Abstract17.html, 2022
Pheochromocytoma is a rare catecholamine secreting tumor which arises from adrenal medulla and extra-adrenal sites. Its clinical presentation is sustained or intermittent hypertension often with paroxysmal symptoms. Imaging studies and estimation of catecholamines and metanephrine in a 24 hours urine sample helps to arrive at definite diagnosis. Correct diagnosis is very important because resection of tumor dramatically reverses clinical symptoms. We present a case of adrenal pheochromocytoma in a 34-year-old female patient to highlight its rarity, clinical presentation and histopathological features.
The Therapeutic Options Indicated in Malignant Pheochromocytoma: About A Single Case
IOSR Journals , 2019
The pheochromocytoma is a rare tumor. Loco regional extension and the presence of metastasis define the malignant pheochromocytoma. We reported a case of a 45-year-old female patient having unresecable pheochromocytoma relapse with local extension and diaphragmatic and lymph node metastasis treated by chemotherapy and target therapy with therapeutic failure. The objective of our publication to make a review for the therapeutic options indicated in malignant pheochromocytoma.