Scientific heading: Chemokines PF4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion (original) (raw)

This study investigates the distinct subcellular localization and secretion mechanisms of chemokines PF4/CXCL4 and CXCL4L1. CXCL4, primarily produced in megakaryocytes, exhibits a regulated secretion process tied to platelet activation and plays a role in various physiological processes, including coagulation and angiogenesis. In contrast, CXCL4L1 shows a different localization and secretion pathway, characterized by its constitutive release and minimal regulatory modulation by protein kinase C (PKC) in certain cell types. The findings suggest that the differential regulation of these chemokines may have implications for understanding their respective roles in immune responses and pathological conditions.