Role of Biomarkers in Cardiotoxicity (original) (raw)
Cardiotoxicity is the ‘toxicity that affects the heart which includes direct effect of the drug on the heart as well as indirect effect due to enhancement of haemodynamic flow alterations or due to thrombotic events. It is associated with small changes in blood pressure and arrhythmias to cardiomyopathy. Hypertrophic cardiomyopathy (HCM), a cardiac disorder is associated with asymmetric cardiac hypertrophy with involvement of the interventricular septum. HCM is caused by mutation in genes such as Myosin-binding protein C (MYBC3), heavy chain of beta myosin (MYH7), troponin T (TNNT2) and troponin I (TNNI3). The most recurrent mutation is seen in MYBC3, MYH7 around 13-25 % while TNNT2, TNNI3 shows below 5%. Similarly, pulmonary arterial hypertension (PAH) is an obstructive disorder of the smallest pulmonary arteries, in which progressive narrowing increases pulmonary vascular resistance which leads to right heart failure and death. PAH is caused by imbalance of activation of transform...
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