Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes (original) (raw)
Related papers
2020
Aims: To investigate the association between Total Bilirubin levels and Diabetic Retinopathy in patients with Type 2 Diabetes Mellitus. Material and Methods: In this prospective, randomized study, a total of 60 diabetic patients presenting to Subharti Hospital, Meerut were divided in following categories. 1) Mild Non-Proliferative Diabetic Retinopathy (NPDR). 2) Moderate NPDR. 3) Severe NPDR. 4) Proliferative Diabetic Retinopathy (PDR) 5) No DR. The eye with worse retinopathy was chosen for inclusion in the study examinations. If both eyes had equal retinopathy, the right eye was assigned to the study. Cases were followed up at 1 week, 1 month and 6 months after first visit. Serum total bilirubin levels were measured at each follow-up visit. Observation and Result: On correlation analysis, the two variables Diabetic retinopathy Fundus grading and Total Serum bilirubin levels are inversely and significantly correlated at baseline, 1 week, 1 month and 6 months. Conclusion: Serum bilir...
Association Of Serum Total Bilirubin Level With Diabetic Retinopathy In Type 2 Diabetes Mellitus
Journal of Ayub Medical College, Abbottabad : JAMC, 2016
BACKGROUND Serum bilirubin has anti-inflammatory, antioxidant and immunological properties. It is considered a protective substance against atherosclerotic and microvascular complications of diabetes mellitus (DM). This study was designed to find the association between total serum bilirubin concentration and diabetic retinopathy (DR). METHODS This case control study was conducted in the Department of Endocrinology, Diabetes and Metabolic Diseases, Hayatabad Medical Complex, Peshawar. Type-2 DM patients more than 18 years of age of either gender with duration of T2DM more than 6 months were included and sub categorized in two groups. Cases (DM with DR) and Controls (DM without DR) while patients with acute and chronic liver diseases, haemolytic anaemia, history of chronic alcohol consumption, use of hepatotoxic drugs (anti-tuberculous, anti-epileptic), women on oral contraceptive pills were excluded. All participants underwent ophthalmic examination at diabetic retinopathy screening...
Association of bilirubin and malondialdehyde levels with retinopathy in type 2 diabetes mellitus
Indian Journal of Endocrinology and Metabolism, 2015
Introduction: Bilirubin as an antioxidant and malondialdehyde (MDA) as an oxidant have been shown to be associated with various complications of type 2 diabetes mellitus (DM). Aims and Objectives: The aim was to measure the levels of serum bilirubin and MDA in type 2 DM patients with and without diabetic retinopathy (DR) and to correlate them with severity of DR. Materials and Methods: A total number of 120 subjects out of which 40 were controls without type 2 DM and the rest 80 were type 2 DM patients were included in the study. Of those 80 diabetics, 44 patients did not have DR and 36 patients had DR. Results: The total bilirubin, direct bilirubin, indirect bilirubin were higher in controls as compared to cases (P = 0.017, 0.033, 0.024). Serum MDA levels were found to be higher in diabetics as compared to controls (P = 0.00). The values of all the three parameters, that is, total bilirubin, direct bilirubin and indirect bilirubin were lower in patients with retinopathy as compared to those without retinopathic changes (P = 0.00, 0.020, and 0.007). Subjects were assigned to quartiles based on serum total bilirubin concentration. The prevalence of DR was significantly lower among persons with the highest bilirubin quartile compared to those with the lowest quartile. The severity of DR was inversely proportional to the total bilirubin levels (P = 0.001). The multiple logistic regression analysis showed total bilirubin to be associated with prevalence of DR (P = 0.035). Conclusions: The levels of total bilirubin were significantly lower in patients with DR and also in the late stages of retinopathy as compared to those without retinopathy and in controls but MDA levels did not show any association with DR.
PLOS ONE
Objective Previous reports have demonstrated the association of serum bilirubin levels with the progression of diabetic nephropathy. The objective of this study is to assess the association of basal bilirubin levels with progressive renal decline (PRD) and end-stage kidney disease (ESKD). Methods A total of 298 patients with diabetes who visited Kyushu University Hospital (Japan) were recruited and followed up for 10 years. PRD was defined as a negative change in estimated glomerular filtration ratio (eGFR) >3.7%/year, 2.5th percentile. Logistic regression analysis was performed to evaluate the association of total bilirubin levels with PRD and its cut-off point was determined by receiver operating characteristic (ROC) analysis. Kaplan-Meier method and Cox hazard regression analysis were used to evaluate the predictive ability of its cut-off point for ESKD. Results Logistic regression model showed that total bilirubin levels were significantly associated with PRD, and ROC analysi...
Sohag Medical Journal
Background: One of the major complications of type 2 diabetes is diabetic nephropathy (DN). Nephropathy develops in ~20-40% of patients with diabetes and is the single leading cause of end-stage renal disease (ESRD) around the world.(1) Oxidative stress has been considered to be an important pathogenic factor in the development of diabetic vascular complications, including nephropathy. Bilirubin(BIL) has been recognized as an endogenous antioxidant. Objective: The objective of this study is to detect the relationship between serum bilirubin concentrations and diabetic nephropathy in patients with type 2 diabetes mellitus. PATIENTS & METHODS:The study included 92 patient with type 2 diabetes mellitus who visit Sohag University Hospital ,All patients in this study were subjected to full history taking, complete physical examination, and laboratory investigations including urine analysis, albumin creatinine ratio, renal and liver function tests. Patients with T2DM were recruited and bilirubin concentrations were compared between patients with or without diabetic nephropathy. DN was diagnosed according to KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease .(7) Patients were classified according to stage of nephropathy (8): Conclusions Serum bilirubin concentration correlated negatively with stage of diabetic nephropathy, which suggests that bilirubin has a potential role for protection of diabetic nephropathy.
BackgroundIn type 2 Diabetes Mellitus (T2DM) chronic hyperglycemia leads to multi-organ damage. It is a chronic low-grade inflammation resulting in reduced antioxidants leading to many complications. Hyperglycemia causes glycation of serum proteins forming advanced glycation end products (AGEs). HBA1c is an AGE of haemoglobin. Bilirubin considered a waste product of the heme catabolic pathway, has proven to be a natural antioxidant associated with a lower prevalence of oxidative stress-mediated diseases. Bilirubin prevents glycation of proteins providing benefit in T2DM. General objective - To evaluate the association of serum bilirubin levels with HBA1c, FBS, PPBS in diabetes patients. Specific objectives - 1) To compare the serum bilirubin levels in diabetes patients with good and poor control. 2) To evaluate the association of HbA1c with FBS, PPBS and age in controlled and uncontrolled diabetes mellitusMethodology -A retrospective analytical study done at the department of Haemat...
Journal of diabetes and its complications, 2015
Although relationships of serum bilirubin concentration with estimated glomerular filtration rate (eGFR) and urinary albumin excretion (UAE) in patients with type 2 diabetes have been reported, whether such relationships exist in patients with type 1 diabetes is unknown. A total of 123 patients with type 1 diabetes were investigated in this cross-sectional study. The relationship between bilirubin (total and indirect) concentrations and log(UAE) as well as eGFR was examined by Pearson's correlation analyses. Multivariate regression analyses were used to assess the association of bilirubin (total and indirect) with eGFR as well as log(UAE). A positive correlation was found between serum bilirubin concentration and eGFR; total bilirubin (r=0.223, p=0.013), indirect bilirubin (r=0.244, p=0.007). A negative correlation was found between serum bilirubin concentration and log(UAE); total bilirubin (r=-0.258, p=0.005), indirect bilirubin (r=-0.271, p=0.003). Multivariate regression ana...
Serum Bilirubin is Significantly Associated with Hba1c in Type 2 Diabetic Subjects
Endocrinology&Metabolism International Journal
Diabetes mellitusis a group of metabolic diseases characterized by increase blood glucose level defects in insulin secretion and insulin action. Bilirubin has anti-inflammatory, antiapoptotic and antioxidant properties. As an antioxidant, it has been shown to suppress the oxidation of lipids and lipoproteins; especially LDL-cholesterol. The present study was conducted to assess the relationship between serum bilirubin levels with insulin resistance and other potential risk factors of diabetes in type 2diabetic subjects. This cross sectional study was conducted on 200 type 2diabetic subjects who attended Amin Hayat Memorial Hospital in Lahore. Patients with age group 27-64years were included in the study. Out of which 90 were males and 110 were females. Different demographic and biochemical parameters as age, BMI, WHR, Blood pressure, personal history and socioeconomic status were recorded while fasting blood glucose and random blood glucose. HbA1c, lipid profile and serum bilirubin levels, serum insulin by chemistry analyzer and ELISA. HOMA IR was calculated. The level of bilirubin showed negative significant association with fasting blood glucose, HbA1c and cholesterol, LDL-cholesterol and triglycerides while non significant association was observed with BMI (Kg/m²), WHR, B.P
The Korean journal of internal medicine, 2017
We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of 349 patients with T2DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were enrolled. The main outcome was the development of CKD stage 3 or greater. The patients were divided into four groups according to the quartiles of the total serum bilirubin levels at baseline. The group with the lowest range of total serum bilirubin level (Q1) showed the highest cumulative incidence of CKD stage 3 or greater than that of the other lower quartiles (Q1 vs. Q4; hazard ratio [HR], 6.75; 95% confidence interval [CI], 1.54 to 29.47; p = 0.011). In multivariate analysis, the risk of developing CKD stage 3 or greater was higher in the second lowest quartile of the serum bilir...
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Background: Diabetic kidney disease (DKD) is one of the major complications of Type 2 diabetes, clinically characterized by a progressive increase in albuminuria and/or a subsequent decline in glomerular filtration rate. Identification of novel risk factors contributes to reduction in the risk of diabetic kidney disease. Bilirubin, as an antioxidant and anti-inflammatory molecule, is believed to have a protective role in kidney disease. On the other hand, uric acid is implicated in the pathogenesis of DKD due to its pro-oxidant and pro-inflammatory property in vascular tissues. Methods: A hospital based comparative cross-sectional study was conducted from October 2020 to March 2021 on 200 eligible Type 2 diabetic patients (58 with DKD and 142 without DKD) to assess the association of serum total bilirubin and serum uric acid levels with low GFR diabetic kidney disease using consecutive sampling technique. Results: The serum total bilirubin level was significantly decreased (0.15±2.29, mean±SD) in the DKD group compared to the non-DKD group (0.19±2.26), whereas the mean±SD serum uric acid was significantly increased in the DKD group (7.13±2.21) compared to the non-DKD group (5.24±1.92). A low serum total bilirubin level was significantly associated with increased risk of DKD in multivariate analysis (AOR=2.23, 95% CI=1.55-4.13) also to high serum uric acid levels (AOR=2.09, 95% CI=1.06-4.12). Moreover, a low serum total bilirubin level was significantly associated with increased risk of DKD among patients with high serum uric acid (AOR=2.55, 95% CI=1.05-6.19). Similarly, high serum uric acid was significantly associated with increased risk of DKD among patients with low serum total bilirubin (AOR=3.49, 95% CI=1.29-9.42). Conclusion: Co-presence of low serum total bilirubin and high serum uric acid may be useful for stratification of DKD risk among patients with Type 2 diabetes mellitus.