Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood (original) (raw)

Childhood body mass index and development of type 2 diabetes throughout adult life-A large-scale danish cohort study

Obesity (Silver Spring, Md.), 2017

This study investigated how a wide spectrum of body mass index (BMI) values at ages 7 to 13 years are associated with type 2 diabetes throughout adulthood, including potential modifying effects of sex and birth weight. From the Copenhagen School Health Records Register, 292,827 individuals, born between 1930 and 1989, were followed in national registers for type 2 diabetes (women, n = 7,472; men, n = 11,548). Heights and weights were measured at ages 7 to 13 years. Below-average BMIs, with few exceptions, were not associated with type 2 diabetes. Above-average BMIs had positive associations that were stronger in women than men, stronger in younger birth cohorts, and weaker with older age at diagnosis. Women born 1930-1947, 1948-1965, and 1966-1983 with above-average BMIs at 13 years (≥18.2 kg/m(2) ) had hazard ratios (95% confidence intervals) ranging from 2.12 (1.91-2.36) to 2.84 (2.31-3.49) per z score when diagnosed at 30 to 47 years. Birth weight did not modify these association...

Undernutrition and suboptimal growth during the first year are associated with glycemia but not with insulin resistance in adulthood

Cadernos de saude publica, 2021

This study aimed to assess whether weight, length, and conditional growth during the first year are associated with glycemia and insulin resistance among young adults. A non-concurrent longitudinal design was used in the study. This is a population-based cohort study, composed of people aged from 22 to 28 years. We estimated z-scores from birth to the first year and the infants were classified as stunted, underweight, overweight, obese, wasted, and at risk of wasting, using cut-offs proposed by the World Health Organization (Child Growth Standards, 2006). Conditional weight and length gain variables were estimated. Glycemia, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and single point insulin sensitivity estimator (SPISE) were evaluated in adulthood. Multiple linear regressions that includes the variables associated with glycemia and insulin resistance were used. In total, 1,070 subjects were evaluated and glycemia in adulthood was higher among subjects wh...

Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes

Diabetes Care, 2020

OBJECTIVE We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association. RESEARCH DESIGN AND METHODS Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20–71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazards regressions and meta-analysis techniques. RESULTS Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls 5.04 [95% CI 3.92–6.48]; HRboys 3.7...

Association of Diabetes Mellitus and Nutritional Status in Children 7 to 11 Years with High Birth weight

Ommega Online Publishers, 2016

Introduction: Diabetes Mellitus type 2 (DM2) is a chronic disease characterized by absolute or relative failure of a hormone produced by the pancreas, called insulin and is characterized by an alteration in the metabolism of proteins, fats and carbohydrates[1-3]. Objective: Identify whether the high birth weight in children aged 7 to 11 years is a predictor for the association of overweight and obesity with diabetes mellitus. Method: A descriptive study was conducted with a design case - control with children born between January 1992 and December 1995. Results: Encontramos in the study group that overweight 2.85% is pre diabetic and 1, 44% diabetic, in obese 1.42% is pre-diabetic and diabetic 3.56%, where there Fisher’s P = 0.0002 association between nutritional status (overweight, obesity) pre diabetes and diabetes; in the control group, in overweight we found that 3.00% diabetic and diabetic pre 0.00% in obese diabetic pre 1.00% and 2.00% with a diabetic Fisher’s P = 0, 0343, existing association between nutritional status and pre-diabetes and diabetes in this group association between nutritional status and diabetes was also found, so there is no difference in the two groups, but we must note that in the study group his association was stronger. In our study is not high birth weight per, association for diabetes. Conclusion: The high birth weight (macrosomia) does not constitute per se a predictor for the association of malnutrition by excess and diabetes, association for excess malnutrition and diabetes in both groups.