Phytochemical Screening and Assessment of Pharmacological Properties of Swertia chirayita (Roxb. ex Fleming) Root Methanolic Extract (original) (raw)
Related papers
Phytochemical investigation of crude methanol extracts of different species of Swertia from Nepal
BMC Research Notes, 2015
Background: The genus Swertia is reported to contain potent bitter compounds like iridoids, xanthones and c-glucoflavones that are known to heal many human disorders. In contrast to high ethnomedicinally valued Swertia chirayita, its other species have not been studied extensively, in spite of their common use in traditional medicinal system in Nepalese communities. So, the present study attempts to investigate the content of total polyphenols, flavonoids, antioxidant activity and estimate the rough content of amarogentin, swertiamarin and mangiferin from different species of Swertia from Nepalese Himalayas. Methods: Whole plant parts of S. chirayita (SCH), S. angustifolia (SAN), S. paniculata (SPA), S. racemosa (SRA), S. nervosa (SNE), S. ciliata (SCI) and S. dilatata (SDI) were collected; total phenolic and flavonoid contents were quantified spectrophotometrically and in vitro DPPH free radical scavenging assay was measured. Thin layer chromatography was performed on TLC aluminium plates pre-coated with silica gel for identification of swertiamarin, amarogentin and mangiferin from those species and semi quantitative estimation was done using GelQuant.NET software using their standard compounds. Results: The phenolic content was highest in the methanol extract of SCH (67.49 ± 0.5 mg GAE/g) followed by SDI, SRA, SNE, SCI, SPA and SAN. The contents of flavonoids were found in the order of SCH, SPA, SRA, SNE, SDI, SCI and SAN. Promising concentration of phenolics and flavonoids produced promising DPPH free radical scavenging values. The IC50 values for the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test was lowest in SCH (23.35 ± 0.6 μg/ml), even lower than the standard ascorbic acid among the seven studied species. A significant correlation of 0.977 was observed between the polyphenol content and antioxidant values. The TLC profile showed the presence of all three major phytochemicals; amarogentin, swertiamarin and mangiferin in all of the plant samples. Conclusion: Among the seven studied species, SCH showed anticipating results in total phenol content, flavonoid content and DPPH radical scavenging test. The less considered species of Swertia can be a potential source of bioactive amarogentin, and other useful therapeutic compounds in the alarming status of Swertia chirayita as shown by the phytochemical analysis.
Chemical Composition and Pharmacology of a Medicinal Herb: Swertia Chirata
Internationale Pharmaceutica Sciencia, 2020
Swertia chirata is used as folkore medicine in the treatment of mental disorders ulcers, liver disorder, febrifuge, anthelmintic, antimalarial, skin diseases etc. Phytochemical screening of the extract prepared by soxhlet apparatus confirmed the presence of broader range of bioactive chemical constituents like steroids, tannins, phenolics, saponins, alkaloids, flavonoids, and glycosides. So, the present review based on whole literature available about the medicinal plant was designed to describe the whole work which is carried out about the Swertia chirata. We have also summarized the possibilities of carrying out of unexplored work on the plant in the future.
Swertia Chirata: A Comprehensive review of its abundant medicinal properties
International Journal of Unani and Integrative Medicine
Swertia chirata (S chirata), (Family Gentianaceae) is a well-known herbaceous plant. It is very popular in traditional systems of medicine like Unani, Ayurveda, and Siddha. It is commonly used in Unani medicine, for several pharmacological effects including Musaffi-i-Dam (blood purifier), Muqawwi-i-Mida (stomachic), Muhallil-i-Awram (anti-inflammatory), Muqawwi-i-Qalb wa Jigar (tonic to heart and liver), Mulattif (demulcent), Mudir (diuretic), Mulliyin (laxative) properties. It is used for chronic fever, malaria, anemia, liver disorders, hypertension, dyspepsia, gastritis, ulcers, constipation, and skin diseases, and is included in many pharmacopoeial and non-pharmacopoeial preparations. The entire plant contains ophelic acid, two bitter glycosides chiratin, and amarogentin. It also contains resins, tannin, gum, carbonate, and phosphate of potash, lime, and magnesia. Extensive studies on S. chirata have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which includes anti-inflammatory, anti-diabetic, antimicrobial, and antioxidant properties. The present review is an effort to provide a detailed survey of the literature, scientific researches of pharmacognostical characteristics, chemical composition, and pharmacological activities of this plant.
Abstract: Medicinal plants are crucial for about 80% of the world population in developing and developed countries for their primary and basic health care needs owing to better tolerability, superior compatibility with human body and having lesser side effects. The present study was conducted on various solvent extracts of three plant samples of Indian and Nepali origin Swertia Chirayita (Roxb.) Buch-ham (Chiratia) collected from various places to establish their comparative phytochemical analysis, chromatographic profile, hepatoprotective and antioxidant activities. Nepali Swertia Chirayita was found to have finest Chromatographic profile (TLC). Phytochemical analysis revealed Alkaloids, flavonoids, saponins, ascorbic acid, glycosides, steroids and triterpenoids in all samples. Different solvent fractions of the methanolic plant extracts of Swertia chirayita were assessed for hepatoprotective activity by carbon tetrachloride- induced liver damage in rats. The grade of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT/AST), alkaline phosphatase (ALP), serum glutamate pyruvate transaminase (SGPT/ALT) and total bilirubin. The in-vitro antioxidant activity of the extracts was also evaluated by the 1, 1-diphenyl- 2-picrylhydrazyl (DPPH) free radical scavenging assay. The methanolic and aqueous extracts, at a dose of 200mg/kg and 300mg/kg, produced significant (P<0.05) hepatoprotection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions. Decreased observed in the biochemical parameters suggests that the plant extracts possesses hepatoprotective as well as antioxidant activities without any significant variation amongst them. These activities reside mainly in the methanolic extract of whole plant.
Background: Swertia chirata Buch.-Ham. ex Wall. is an endangered medicinal herb native to the temperate Himalayan region. The species holds immense ethnobotanical importance in India, Nepal, Bangladesh and Bhutan. The herb is known to host a plethora of bioactive phytoconstituents that imbue it with a wide variety of medicinal properties. Modern research has proven that extracts of S. chirata possess antioxidative, anticarcinogenic, antimalarial, anti-infl ammatory and hypoglycaemic activities. The present article aims at highlighting the medicinal importance of S. chirata along with a brief discussion about its bioactive phytoconstituents. The research work carried out for improving the germplasm conservation strategies for S. chirata have also been elucidated in this review. Methods: In-depth analyses of S. chirata have been performed to outline its phytochemical profi le in order to gain a better understanding about its medicinal attributes. Various techniques have also been applied for in vitro germplasm conservation of S. chirata. Result: S. chirata contains numerous potent bioactive compounds that contribute to its medicinal value. The unsupervised exploitation of natural reserves of S. chirata by pharmaceutical companies has driven the species on the verge of extinction, thus making in vitro germplasm conservation of the same essential. Conclusion: The importance of S. chirata as a cure for numerous ailments and health disorders has been welldocumented in traditional and modern medicine. The application of various modern techniques has not only allowed scientists to identify numerous medicinally important compounds present in S. chirata, but also created a platform for maintaining adequate production of this versatile medicinal plant species.
Review on Swertia Chirata as Traditional Uses to Its Pyhtochemistry and Phrmacological Activity
Journal of Drug Delivery and Therapeutics, 2018
Swertia chirata (Gentianaceae), is a popular medicinal plant native to temperate Himalaya. The plant of Swertia chirata is found at an altitude of 1200-1300m, from Bhutan to Kashmir and in the Khasi hills at 1200-1500m. It also can be grown in sub-temperate territories between 1500-2100m altitudes. Chirata has an erect and about 2-3 ft long stem. Herbal medicinal plants are necessary for about for about 80% of the world population in developed and developing countries for their basic and primary health care required owing to better tolerability, superior empathy with human body and having lesser side effects. Herbal plants are considered as rich source of phytochemical ingredients. The main chemical ingredients are Swertiamarin, Amarogentin, Swechirin, Mangiferin, Sweroside, Gentianine, Amaroswerin, Oleanolic acid, Swertanoone, Ursolic acid. Phytochemical analysis divulges alkaloids, flavonoids, steroids, glycosides, triterpenoids, saponins, xanthones and ascorbic acid in all sampl...
In the present study the leaves of Swertia chirayita were subjected to phytochemical analysis and the impact of the leaf extract of Swertia chirayita was tested against Staphylococcus aureus, Bacillus subtilis and Salmonella typhi. The phytochemical analysis revealed the presence of various phytochemicals such as alkaloids, flavonoids, phenols, quinones, saponins, tannins and terpenoids. The antibacterial activity was done by Agar disc diffusion method and the result showed that the leaf extract of Swertia chirayita showed 100% inhibition of all the test bacteria. The Minimum Inhibitory Concentration (MIC) of Swertia chirayita leaf extract that showed 100% inhibition was 0.13 mg, 0.36 mg and 0.13 mg in case of Staphylococcus aureus, Bacillus subtilis and Salmonella typhi respectively.
Medicinal importance of Swertia chirayita in Unani system of medicine
Background: Herbs orchestrate resurgence and vegetal awakening is supervened everywhere in the world. Medicinal plants always played an important role in the health development of mankind. Chirayita provides us new lead molecules for the development of drugs against various pharmacological targets. Plants included in this family are annual and persistent herbs or shrubs, indigenous to northern moderate stretch of the world. Objectives: Swertia Chirayita is well known for its medicinal and pharmaceutical importance. In this review studies I will wanted to explore the various pharmacological properties of Chirayta in Unani system of medicine. Methods: I searched Unani Pharmacopeia of India, Publication of National Herbarium Bangladesh, Bangladesh National Unani Formulary, ND Health facts & PubMed, internet data from inception up to 31March 2018 observational data relating to Chirayta with Unani system of medicine. Results: Evidence suggests that various listed of Unani Medicine formulated with the Swertia Chirayita among these few are tablet, capsule, syrup and semi-solid etc. Conclusions: Basically, Swertia chiretta is a conventional medicinal plant that used in Unani system of medicine. Farming of this very essential and endangered medicinal species should be promoted.
Comparative Pharmacognostic Evaluation of Three species of Swertia L. (Gentianaceae)
Pharmacognosy Journal, 2011
Swertia spp. (Gentianaceae) commonly known as Chiraita in herbal drug markets of India is used to protect liver and a wide range of diseases. The official species Swertia chirayita (Roxb.) Karsten is known for its potent activity against malaria, liver-disorder, fever, diabetes and also as appetite stimulant. However, several other species of Swertia viz. S. alata (Royle ex D. Don) clarke and S. paniculata Wall. are being used as substitutes /adulterants for S. chiraita in India, Japan, china, Pakistan and other Asian countries. In the present communication a comparative botanical, phytochemical and qualitative analysis of biomarker Oleanolic acid in S. chirayita along with two allied species of Swertia has been done.