Control of Nanoparticle on Nanofiber via Magnetic Electrospinning (original) (raw)
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Application of magnetic electrospun polyvinyl alcohol/collagen nanofibres for drug delivery systems
Molecular Simulation, 2020
A magnetic electrospun nanofibre was prepared and applied to load and release bovine serum albumin (BSA). Fe 3 O 4 magnetic nanoparticles were prepared by chemical co-precipitation of ferric and ferrous salts and coated with polyvinyl alcohol/collagen electrospun nanofibre. Tripolyphosphate (TPP) and glutaraldehyde were used to stabilise nanoparticles within the electrospun nanofibres. It was found from scanning electron microscopy graphs that TPP is more suitable than glutaraldehyde and a network of relatively tall and perfectly uniform fibres with smooth surface can be produced and magnetic nanoparticles in their smallest size are distributed all over the fibres network without any agglomeration. BSA protein was loaded in magnetic nanofibres and its releasing under magnetic field and in the absence of magnetic field was studied using the Bradford assay method. The magnetic nanofibres completely changed the structure and formed pores and cracks under the magnetic field and then released BSA after 3 h, about 12 times higher than its releasing in the absence of magnetic field.
2018
Objective: The purpose of this work was design and performance investigation of a nanocarrier based on magnetic nanofibers containing core-shell nanostructuresfor anticancerdrug delivery of daunorubicin (DAN) by measuring their drug release at different pH values. Methods: Fe3O4 nanoparticles and Fe3O4@SiO2core-shell nanostructures were synthesized through coprecipitation and Stober methodrespectively. The composite nanofibers of polyvinyl alcohol containing core-shell nanostructures and anticancer drug of daunorubicinwere fabricated by electrospinning method.The nanostructures were characterized bySEM, XRD,VSM and FTIR techniques. The drug release was investigated by UV-Vis spectrophotometer at different pHs. Results: The results is shown that in vitro drug release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fitted equation of release curves is corresponded to Peppas model. Conclusions: It can be concluded that the proposed nanocarrier is capable of ...
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
Pharmaceutics
The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties...
Electrospinning Nanofibers for Therapeutics Delivery
Nanomaterials
The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanof...
Electrospinning of polymeric nanofibers for drug delivery applications
Journal of Controlled Release, 2014
Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factors have been incorporated into electrospun fibers. This article presents an overview of electrospinning techniques and their application in drug delivery.
Electrospun PVA-Pectin-Magnetite Nanofiber as a Novel Drug Carrier Matrix
ABSTRACT Composite nanofibers have received a lot of attention due to their multifunctional behavior. Some interesting properties can be induced in nanofiber through incorporation of nanoparticles. In present work, PVA-pectin-magnetite nanofiber was prepared using electrospinning method. The morphological studies of the composite nanofibers were performed by AFM (atomic force microscope) and by FE-SEM (field emission scanning electron microscope). The chemical composition of the imaged nanofibers was determined from energy dispersive X-ray spectrometry (EDX). The magnetic property of the nanofibers was due to incorporation of Fe 3 O 4 nanoparticles, which was corroborated from VSM study exhibiting ferromagnetic property and negligible coercivity (saturation magnetization = 9. 34 emu/g). The Fe 3 O 4 phase was further confirmed form XRD study. The loading and release of diclofenac sodium drug from the as-synthesized nanofibers was studied by UV-Visible spectroscopy. The loading of drug was 56. 78 µg mg -1 and exhibited burst release at pH 7. 4 PBS. 630 Pritam Roy and Raj Kumar Dutta
2008
Polymer-stabilized magnetic nanoparticles were obtained using two biocompatible polyelectrolytes: N-carboxyethylchitosan (CECh) and poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS). The size of the particles (mean diameter 10 or 30 nm, respectively) and the stability of the dispersions could be effectively controlled depending on the polyelectrolyte nature. The presence of polyelectrolyte shell was proved by transmission electron microscopy (TEM) studies and confirmed by thermogravimetric analyses. Depending on the polyelectrolyte nature the magnetic nanoparticles existed in different magnetic states -superparamagnetic or intermediate state between superparamagnetic and ferrimagnetic one, as evidenced by the measurements of the magnetization and Mö ssbauer analyses. Fabrication of nanocomposite magnetic fibers with mean diameter in the range 100-500 nm was achieved using electrospinning of the system CECh/ferrofluid/nonionogenic polymer.
2017
Objective(s): The purpose of this study was preparation and evaluation of PVA-Fe3O4 nanofibers as nanocarrier of doxorubicin (DOX) by measuring their drug release together with their in vitro cytotoxicity toward cancer cells at different pH values. Methods: Fe3O4 nanoparticles were synthesized by coprecipitation method. The composite nanofibers of polyvinyl alcohol containing nanoparticles and anticancer drug DOX were fabricated by electrospinning method. The nanostructures were characterized by different techniques. The drug release was investigated by UV-Vis spectrophotometer at different pHs and 37.5 C. Results: In vitro drug release experiments show that the doxorubicin release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fitted equation of release curves corresponds to Peppas model. Also, MTT assays indicate that the MNPs-doxorubicin-loaded nanocarrier has cytotoxicity comparable with free drug. Conclusions: The synthesized nanocarrier was success...
Electrospun functionalized magnetic polyamide 6 composite nanofiber: Fabrication and stabilization
Polymer Composites, 2017
One of the major challenges in the preparation of magnetic nanoparticles is to minimize the aggregation of the obtained nanoparticles. In addition, the presence of functional groups on the surface of the magnetic nanoparticles and the allowance of further functionalizing of these particles with drugs and therapeutic agents are other drawbacks. Functionalized magnetic polyamide 6 composite nanofibers (magnetic PA6) with diameters of 120 and 200 nm were fabricated by electrospinning process. The surface of the magnetic particles was functionalized with polyethylenimine (PEI), 3-aminopropyltriethoxysilane (APTS), polyethylene glycol, and tetraethoxysilane on an individual basis. The dispersion of magnetic nanoparticles within the polymeric solution of polyamide 6 was created and examined by the electrospinning process. The morphologies and diameter distributions of the resultant nanofibers were investigated by scanning electron microscopy (SEM). The APTS/PA6 solution coated magnetic nanoparticles showed better electrospinning performance than the other structures. The dispersion and the morphology of the magnetic nanoparticles in the PA6 nanofiber matrix were investigated using SEM, energy-dispersive X-ray, and transmission electron microscopy. In addition, the thermal stability and magnetic behavior of these nanoparticles were assessed using thermal gravimetric analysis and vibrating sample magnetometer, respectively. The introduced preparation method in this work not only provides nanofibers with controlled size but also homogeneously dispersed the magnetic nanoparticles within the fibers. The combination of high magnetic properties with outstanding thermal stability as presented by the obtained magnetic nanofibers in this study is very promising in the diagnosis and therapy of cancer.
Electrospinning Nanofiber Mats with Magnetite Nanoparticles Using Various Needle-Based Techniques
Polymers, 2022
Electrospinning can be used to produce nanofiber mats containing diverse nanoparticles for various purposes. Magnetic nanoparticles, such as magnetite (Fe3O4), can be introduced to produce magnetic nanofiber mats, e.g., for hyperthermia applications, but also for basic research of diluted magnetic systems. As the number of nanoparticles increases, however, the morphology and the mechanical properties of the nanofiber mats decrease, so that freestanding composite nanofiber mats with a high content of nanoparticles are hard to produce. Here we report on poly (acrylonitrile) (PAN) composite nanofiber mats, electrospun by a needle-based system, containing 50 wt% magnetite nanoparticles overall or in the shell of core–shell fibers, collected on a flat or a rotating collector. While the first nanofiber mats show an irregular morphology, the latter are quite regular and contain straight fibers without many beads or agglomerations. Scanning electron microscopy (SEM) and atomic force microsc...